Abstract:The analysis of soluble proteins and esterase isozyme in F2 progeny grains from wheat (Triticum aestivum L. ) × maize (Zea mays L. ) crosses indicated that the electrophoretic pattern of proteins and esterase isozymes was extremely different from that of their parents. Protein variation was mainly concentrated in the high-molecular-weight-Glu (HMW-Glu) zone. There were 5 kinds of protein eleetrophoretic patterns in the analyzed grains. VIZ: maternal, additional, complementary, hybrid and omission type which accounted for 22.6%, 14.3%, 15.5%, 30. 9% and 16.7% of the total tested grains respectively. In the analysis of esterase pattern, some variations in progenies were also found. The variations of electrophoretic pattern of proteins and esterase isozyme indicated that a genetic material change in wheat chromosomes could be induced in the distant hybridization.