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Chinese Bulletin of Life Sciences
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2010Äê2ÔÂ
Vol. 22, No. 2
Feb., 2010
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Progresses in structure studies of influenza A virus NS1 protein
GUO Ying-ying, WANG Jing-fei *
(State Key Laboratory of Biotechnology, Harbin Veterinary Research Institute,
Chinese Academy of Agricultural Sciences, Harbin 150001,China)
Abstract: Nonstructural protein 1(NS1)have been reported as one of the major virulence factors of Influenza A
virus. The protein is a small, dimeric, multi-functional protein which takes part in both protein-protein and
protein-RNA interactions, and has a crucial role in the ability of the virus to evade the antiviral response of the
infected cells. According to its multiple functions, NS1A protein is made up of two domains: an N-terminal RNA-
binding domain (RBD) (residues 1–73) and a C-terminal effector domain (ED) (residues 84–230/237). The structures
of the two domains have been crystallized. In this review, we described the current understanding of NS1A
structure and function as well as the relationship between them.
Key words: Influenza A virus; nonstructural protein; structure; function
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