Abstract:Huanghuahaosu is a new substance isolated from the leaves and flowers of Artemisia annua Linn. and A. annua Linn. f. macrocephala Pamp. It possesses higher and quicker effect and lower as compared with other anti-malaria medicines. More than 2099 patients who were infected with cerebral malaria,pernicious malaria jtertiana and antichloroquine malaria have been tested withHuanghuahaosu and the clinical effect is l00%.