免费文献传递   相关文献

Progress of methodology for identifying target protein of natural active small molecules

天然活性小分子靶标蛋白识别方法学研究进展



全 文 :)$#
y

z ˜
&
™˜

}
A-I?&$ ;-+ MJ0NJK6$ )$#
!
XY
!
‡ˆ‰Š:‹ŒŽ‘’“”•–—˜
+,-
!
!
./0
!
!
123
!
456

KL?@ HMANCOPAN—QRSTUV
!
KL
$$(#

op
#!
,£ŽZï?À8¬,£©¶žŸê¼½,£†-ìɋŒ

žÉWþ$,,†£ò¹
$
‡ˆ‰Š:‹
ŒžŸf‚¯°
$
ì’ZžŸŽÈÉ[6Z,•–ûªxû5(J
$
ˆ¢Ôøšfg[6bv)Ô]—˜

ž
ûnݹyŸ›‡ˆ‰Š:‹ŒŽ‘’Èɓ.£œ­()
(
­“”—nžu·
$
¬þDEžÔøšfg4–•
–“”
$
{‹Ï¨àO*+
$
ÙO,-.ž|Г”éŸŠ¨Øٓ”7 %/

©vš^݀T‡ˆ,£_
(

Ϩ_™£fg•–?{B[ɝm{;ȞŸ


qrs
#!
‡ˆ‰Š:‹Œ
)
Ž
)
“”
)
‹Œ0{>î
)
‰Šî

jk)(
#!)$53$%34$

|}~T
#!
—QîMB@W6XY
4$4)54!4$%4$%)#

lmAn
#!
!
+,-
!
Z[
!TEI$$$# )$&$&!V3.JFI$ [E0USEFGN1]/.N?ELN?,0%
!
./0
!
\]^_
!TEI$$$#)$&$&!V3.JFI$ O_a1
]/.N?ELN?,0
@21N269917+6051/1.1N? 712-/630-7?-3N 0,2N60:2106-3173,0=2,.
,G0-I69+,.+1.6G=.69
TB@E0U3SEF
!
$ OV;Q_E3*N
!
$ C:2\CF37F$ 8\;Q F`J-3.F0
!2&$&@:A$B)%$&)%:)*C$&=%$?$(0 D-)-&-1!%=5.$ EF-(5 8(-9%.-&:$ D-7-(5 $$($ +,-($
*A;902,G0+!WKNUGJKUEGRJKER[E,FJI.-IE,NIERGHJG,J0 F0GEKJ,G*FGH LKNURJ0L E7EKG[HJK.J,-I-UF,JISN0,GF-0RF0 HN.J0 ]-L6?THE
0JGNKJIJ,GFdER.JI.-IE,NIERJKEGHE]F-J,GFdE]JRFR-SGKJLFGF-0JI[E,FJI6S-KGHEFLE0GFSF,JGF-0 -SGHEFKGJKUEG[K-GEF0R?P-*EdEK$IFGIE[K-UKERRHJR]EE0 .JLEF0 GHFRSFEIL N0GFI0-*?PEKE$ *ERN..J3
KFXEL GHEKE,E0GGE,H0-I-UFERJ0L .EGH-LRS-KGHEFLE0GFSF,JGF-0 -SGJKUEG[K-GEF0R-S0JGNKJI]F-J,GFdER.JI.-IE,NIER$ J0L F0GK-LN,EL
GHE.JF0 KEREJK,H .EGH-LR$ [KF0,F[IERJ0L RN,,ERRSNI,JRERF0 GHFRSFEIL?aEJIR-E7[I-KEL GHEJ[[IF,J]FIFG6J0L LFR,NRREL GHEJLdJ0GJ3
UERJ0L LFRJLdJ0GJUERJ.-0ULFSEKE0G.EGH-LR?aEH-[EGHFRKEdFE*,J0 ]ENREL JRJKESEKE0,ES-KGHEKEREJK,HEKR*H-E0UJUEL F0 0JG3
NKJI[HJK.J,ENGF,JI,HE.FRGK6$ [HJK.J,-I-U6J0L ,HE.F,JI]F-I-U6?
*_6? P12/9+!0JGNKJIJ,GFdER.JI.-IE,NIER) GJKUEG[K-GEF0) .EGH-L-I-U6) .-IE,NIEJSF0FG6,HK-.JG-UKJ[H6) J,GFdFG63]JREL [K-GEF0
[K-SFIF0U
/1-#!b%&(`EG^G++&!(!&
!!
‡ˆ‰Š:‹ŒZ­,•mû5Ÿ>
$
ÔøB©rŽ
+cdŸ,Ü68b 8Ÿ>ó‡ˆ,£

ˆ¢
$
ÏSn
݇ˆ‰Š‹Œ‰Š•–jÄ$›CDuhâ_‰
´¨ù3,†ïŽ$®º
$
+éZ‹Œf‚•–tj
‡ªx[ãµ1,‹v<@N
$
SS2¥-㉊‹Œ6
8žŸŽÈÉ

45{×wǛ󇈉Š‹Œ·
Š«Š{Ï-Š

+wØÙ&ý
(
ØÙFg™Ô,Ÿ¢
£ŠÉy’ij
$
}I—áB‰Š_à‹Ð«
$
·Š×Z4y3’

­ó_Á£·Š68·ÉâI,‹
‰ŠžŸ
$
¢‡ˆ‰Š‹Œ·Šw®Ï-
$
׮IwǞ
ŸŽLq4
$
+éZ[A‰Š‹ŒtwÇÙOž
ŸóAŽ
$
ÈÉgžLqBB“¤Š

͑[A{
,#,
567•
#
‡ˆ‰Š:‹ŒŽ‘’“”•–—˜
×ØZ‡ˆ‰Š‹Œ$ij[1‹_Á£·ŠáBA
‰ŠÙè
$
tØZêI$sážAwÏàÉ,†ž8·
Š
$
×®1¡Z„[1‹m®ž,†
$
I¬ŽZwx
žŸ
.
-ãvJÎÏ)1‚9
$
b¨V›()º‹›©
rÂ
$
×®-tZ‚:‡ˆ‰Š‹ŒŽ¯°gž
[A¢n

Ôø
$
›-;‡ˆ‰Š‹ŒŽ“.
$
ø?qµ
ª«ž[㵈
$
›®š^Ørø4–‡ˆ‰Š‹ŒŽ
ÈÉgž—nžu·{‹¾
$
<›É”ùšfg•–
*Ì[ã(){“”º;È

ØÔø•–—˜Ÿ=
$
‡
ˆ‰Š:‹ŒŽ‘’45ПwŽ[㓔
$

“”¶B%/
$
w©¶;È
$
tw#ÁüŸ

!òó‹Œ0
{>î()‘’‡ˆ‰Š:‹ŒŽ
!
_;

)
ò󉊏î()‘’‡ˆ‰Š:‹ŒŽ

)
#òó‰Š:‹Œ·Š0f>A¸„Á()
)
$
ò󙣣‹“”¾´‡ˆ‰Š:‹ŒŽ
)
%òó
ª’?³v<@N‘’‡ˆ‰Š:‹ŒŽ
)
&I@­
“”

Ž.؋’Ý-㓔{‹{-Ÿ—nACŒ»
{‹ô

!O
òó‹Œ0{>î()‘’‡ˆ‰Š:‹ŒŽ
!
_;

›Ôø—ПxЍŽ‘’()$
$
:‹Œ0{
>î”
!R.JI.-IE,NIEJSF0FG6,HK-.JG-UKJ[H6
Z-ŸRÉ¿
À[Ð
*3)+

Ôø-Ÿš”qµ‘’êÈɞst‡ˆ‰
Š‹Œ›8jß,£‹ŒŽ

Ôø:‹Œ0
{>î”[†ü5݉Š:‹Œ·Š—nAB
$
@ê_
CÜߞŽD‹Œ—¢pIE81`a0{FÀº
$
ê—n
Ž±Ä{‘’
*43&+

ŽD‹Œ45Z
]F-GF0$
®‘,
stGìòž
(
_¸-òž
(
ì¸-òž
(
yŠÙÙI
•

Ž.‹’—nBÀDE

!M!O
@êߞ
]F-GF0
ŽD‹ŒŠÆ‡ˆ‰Š:‹Œ`a0
{FÀ
!]F-GF0
Z[Щ݋ŒßÉ
)&&
™£:‹Œ
$
¿À‹Îó|¢£À8

›™£•–$
$
?Öq(Ÿ
]F-3
GF0
¬
JdFLF0!
0{I

7 sÉ·ÁÇ}
$
ݏ¨I@
™£j‹Œ—nŽH{z_±Ä•(ž

Ôøqµm˜£
ž[I›‹àJ
]F-GF03JdFLF0
¬þ
!D28
Ÿó‰Š:‹Œ
Ž±Ä{‘’

+@êp
]F-GF0
¬‰Š:‹Œ—n
_Û®’E8—¢ŠÆ[Ð
]F-GF0
AB‰Š:‹Œ-
n
$
êŸóùԝŽ‘’•–
*53#+

š“”%e›
ó
$]F-GF0
¬
JdFLF0
7 ‹›‡ˆìFŠÑ©¶žŸ
$
×®

JdFLF0
s}KXe
!JUJK-RE
L©FÀ¬
]F-GF0
AB
‡ˆ‰Š:‹Œ7 —n¸-
$

]F-GF0
¬
JdFLF0
©¶
žŸp‰Š:‹ŒLÉês}›L©FÀº
$
—¢Û@ê‰
Š:‹Œ¬7 ©¶žŸ
$
±Ä{z_1©-Ž

!
q

q
!
òó:‹Œ`a0{>î(),£Ž‘’–ë
cFU?!WKNUGJKUEGFLE0GFSF,JGF-0 ]6R.JI.-IE,NIEJSF0FG6,HK-3
.JG-UKJ[H6
!!
­óš”tó(ž
(
éŸ.¿
$
×®•–?{Пš”
qµ±Äꑒ1ž[B­M,£Ž

å%Ñþ
N(J;n݇ˆ‰Š‹ŒOðI
!JLE0J0GHF0
º»¤Ò2
P³ŽO˜žÑž•–
$
I(ŸOðI‹Œ·Š
$‰ŠQòòžžÉ>C
$
@ê›IºE8ÔD
]F-GF0
‹Œòž—¢ŠÆž
]F-GF0
_OðI-n‹Œ
!]F-3JLE0J03
GHF0$
êç®±Ä1ž©-ŽÉêR_£t
![EK-73
FKEL-7F0
/{
[EK-7FKEL-7F0
0
$
q
)J
—[3•–mœ
$
O
ðIwÏ@ꍄžŸó
[EK-7FKEL-7F0 :
{
[EK-7FKEL-7F0
0
—¢Ê‚IR_‰Š
$
*ËCD8êR_SæM
$

V>_3
<=VD@
!v<@NêRT —P³CD‹_
$
‡œº»
žŸ
*%+

®‘
$
OðI,wÏ@ꍄžŸó
[EK-7FKEL-7F0
/{
[EK-7FKEL-7F0
0UCDEŠžŸ
$
—¢‡œÂp]
º»žŸ
*+

VWì(J;@ê݇ˆÂX‰Š‹Œ
JF03
RIFJLF.EK2
·Š—nAB
$
›IQòò¹ºßž
]F-GF0
Ô
D‹Œ
$
ŠÆžÂX‰Š‹Œ-n
]F-3JF0RIFJLF.EK2 !
q
)]$
—¢±Ä1žIÂXŽÉ
:
1
D
$t
!:__

G
!

2F0RIFJLF.EK2
ÇÚ/YŠžŸó
&#
ÙòZ[\ê¬I¡à
Û®’
$
—¢Ê‚
:__

G
!‰ŠêŽ^
;c3
1
D
X]v<@
N
$
‡œÂXžŸ
*(+

®‘
$
@êŠÆ
]F-GF0
AB
JF0RIFJGKF3
.EK2
‹Œ-n
$
š(J;,-;žIBBÂ^_žŸŽ

@@2>
#
*$+

‡ˆ«£
*FGHJSEKF0 2!ac2
BB°ý
Â^_{ÂPöÊ`‰Š
$9-HJ0
•–;nÝ
ac2
‹Œ·
ŠÁàž
]F-GF0
ABÂ^_‹Œ-n
ac23D!
q
),

Ž±Ä{ÈÉ
$

ac2
wÏìFŠ·Áó$ a
ÉÀ
!F0GEK.ELFJGESFIJ.E0G[K-GEF0
êÛ®·ÁóIòZ
,%,
)$#
y

z ˜
&
™˜

}
A-I?&$ ;-+ MJ0NJK6$ )$#
[\bò
$
—¢Ê‚CDqö™Ô
$
‡œÂ^_žŸ
*+

Û
B
$
€cVdš
2%$&-$ ?-H=*$1-(.
$*v)1‡ˆ«£
c>%%4(
BBò~dPXžŸ
$
ÇÚd)À8e¯Lf
æM
$
ÒZIžŸŽeØ°h

•–?{@귊ýÈ
$
›
I‹Œ$ߞ
]F-GF0
ŽD‹Œ
$
—¢ŠÆž‹Œ-n
DF-GF03
c>%%4(!
q
)L$
êpIs}›L©gXº
$
ˆù@ê:‹
Œ0{>î()
$
±Äêz_1š:‹ŒŽÉh
\t
3)2![H-R[HJGJRE)2$@@)2
+
c>%%4(
wÏ@êʂ
@@)2
‰Š—¢^‚Ži
V>_
v<@N
$
‡œdPX
žŸ
*)+

q
)!
òó:‹Œ0{>î()‡ˆ‰Š:‹Œ-nŠÆ
!
Ë>ŽHÉ_AB1Ù

cFU?)!WERFU0 -S0JGNKJIJ,GFdER.JI.-IE,NIE[K-]E]JREL -0 R.JI.-IE,NIEJSF0FG6,HK-.JG-UKJ[H6!.-LFSFEL RFGEFR.JKZEL ]6
UKJ6
!M&O
@ê¬MRòž¸-ŠÆ‡ˆ‰Š:‹Œ`a0{F
À
!
MR‰ŠòžZ[ÐÏMR€jÉòQ·Š¸-ò
ž
$
IwϛkŠßàŽ¬_Á£‹Œ$Qò—nÛ®’
·Á
$
—¢‡œÝ:‹Œ·ŠAB
V[-763J,GFdJGEL 8E[HJ3
K-RE#D]EJLR
ZÔøéŸzɖn[ÐMR‰ŠòžAB
L©FÀ
$
IwϬáBQò·Š_:‹Œ—n¸-
êp:‹Œ’Á1L©FÀu.
$
êŸó:‹ŒŽ
±Ä•–

!l5þN(J;•–ž‡ˆmòn8f
:M35
ÂXžŸ¨Ž
$
I@ê(Ÿ
:M35
‹Œ·Š$‰Š

$
pI¬
V[-763J,GFdJGEL 8E[HJK-RE#D]EJLR
—n¸-
$
¡
àÛ®’E8
$
—¢p
:M35
‹Œ’Á1žšL©FÀu.

­ù(Ÿ
:M35
¬Ž7 ©¶žŸ±Äꑒ1ž
©-ŽÉÀIE8t
B],P5!
q
)E
­ù•–m
œ
$:M35
wÏ@ê¬
B],P5
òZ[\‰ŠÙè7 ¡àÛ
®’E8
$
—¢Ê‚ÀI‹Œ¬
B],P5
·Á
$
€¢Ê‚
;c3
1
D
X]v<@N$‰
$
‡œÂXžŸ
*4+

͑
$
,B
ûpo¼I
!,NK,N.F0
¬
V[-763J,GFdJGEL 8E[HJK-RE#D
]EJLR
—n¸-—¢)1o¼Is}L©FÀ
$
ˆù±
Ä{z_©-Ž

µôWpf‹Ç{
92CW:=
T\c=T\c
îÈÉùmœž£`зÁ
$
st·Š
Š
!GN]NIF0$J,GF0 $
CDPr©ªt
!
q+_t
$
he¯\âÙt
$
Ðe
3$#3
ôh\rxt
$
ϨCDst
©ªt
!
Ðuv
%$
êR_£t
)
ÒZ-㏐
ZwZo¼I‹ŒìFŠ·ÁŽ,B3—[3
•–
*&+

!MaO
@ê¬I@¾hòž¸-ŠÆ‡ˆ‰Š:‹Œ`a0
{FÀ
!
xk€I
!ER,NIEGF0
BBz~Â·y]žŸ
$
Ò
ZIžŸŽeØ°h
$
•–?{(Ÿš_Á£·Š$á
BzQòìè
$
é7¬{_|‰_
<;DK38E[HJK-RE&D
m
™¸-
$
—¢ŠÆ
ER,NIEGF0
ABL©0{FÀ

•–?{
(ŸšFÀ±Ä1ž©-ŽÉ !
3
E
!
!
3,JGE3
0F0$ER,NIEGF0
wǬ£}$
C6R4)$QI64$%$C6R4&5
{
2R04%
•[ò\òžm™68©¶žŸ
$
ʂ !
3,JGE0F03
T,S
$Á£¡à
$
d)CD‹‰!
$
—¢‡œÂ^_ž
Ÿ
*5+

~®7‘
$
,BÐI@¾h0{òwÌéŸ
$
w
2SFQEI$T-6-[EJKI$2^ B2c:>9B8$8Q]EJLR
•
$
ݮqBI
7^`—nž¬þ‹ô{Žz
*#+

-¯)[*Z
$
›-Ÿ‹Œ0{>î()±Ä1©
-Žù
$
Ôø45@ê詁î
!C<398=98
()
—n[–£}ÈÉ
$
tØZp±Ä1«âµ
,,
567•
#
‡ˆ‰Š:‹ŒŽ‘’“”•–—˜
êpfU€ù—¢>
$
êp©-ß›mǎŸ—n
‹ô

[†Ÿ‚
$
pfU€ù«âŠ©ÝsÉ
$

& f
SìßàŽi‹

Azƒ„

&O
ò󉊏î()‘’‡ˆ‰Š:‹ŒŽ
‰Šî()
!J,GFdFG63]JREL [K-GEF0 [K-SFIF0U$2D3
@@
45Z(Ÿ_Áà›BØÙOǎD
!

(
…†
(
‡ò•

:‹Œ-n¬Ž¡àÛ®’
$
—¢Çڛ
ÁÂÏ-™£«â$ŽH
(
³´
(
‹ÇŽ­(
)
*%+

[†Ÿ‚
$2D@@
$韝:‹Œ-nsáB[A0
Uòž
$
IÇÚ¬Ž‰Šˆ‰C¹0«[ò\m™
¸-
$
—¢pš€Ï-hÁÀ¬$‘’ê‹Ç£
Ÿ

×®
$
:‹Œ-n[†›·Šº5sá¸-òž
!
…†
$
‡ò•
$
žŸZé)š‹Œ-n¬·ÁùÇÚ}ùÔ
8žGì|
(
L©ò•ìFŠ‘’
$
—¢‡œGì
ŽH{z_‹ÇÔ
!
q
4 2D@@
ZÔøR†ªx
$
-
Ÿ…èR¿Ž‘’()7[

š()ì’éÁó
:‹Œ¬7 Ç¡àÛ®’·ÁWX
$
×®ü5
:‹Œ›·ŠºáBÇÚ¬m™¸-ONJ·Š
òž
$
Ï,󬍏7 m™¸-¡àÛ®’

I$
$
1
h0Uòžst
#
MRò
$
8f
$
!
3
8Š‹
$
Œ¾
$9F,HJEI
†À•

-
9F,HJEI
†ÀZq’b‡’¬UŒòž
ێ©E¡àÇž
$
š·Št󬙣‰Š‹Œ$
Ñ0«òž
!
òZ[\ò

m™8à¸-
$
—¢«™©
-™£†-

q
4!
ò󉊏î():‹Œ·ŠýÈ
!
Ë>ŽHÉ_ABòž

cFU?4!WERFU0 -SR.JI.-IE,NIERGKN,GNKE]62D@@!.-LFSFEL RFGEFR.JKZ ]6UKJ6
&M!O
‰Šî()
!2D@@
Ÿó‰Š:‹ŒŽ
‘’*+
!
€°{‘
I(5?-1$ F-.F-
$‹Ç£‰Š’“
½:‹Œ
&3H6LK-76LEKF,F0!&3PW
BB¿ÀÂšžŸ
$
Ç
Ú°ýʂü¼>”뚝Ê`
$
ÒZIžŸf‚{Ž
.Øö•

×®•–?{›I{B·Šò¹º
$
@ê_
Áàߞ‡ò·Š
$
—¢ŠÆž:‹Œ-n
!
q
4J
ê@
ꉊî()–—êÈÉ1ž
&3PW
ŽÉa

3G>;2
Áàt
!REK6I3G>;2R60GHEGJRE$8T8
­ó
&3PW
wÏÛ®·ÁóCš
8T8
ºêÝI—n·ŠAB
$
€¢Ê
‚žI˜_[Š_¸-‰Š
$
`™CšÓq™Ô{ς
,(,
)$#
y

z ˜
&
™˜

}
A-I?&$ ;-+ MJ0NJK6$ )$#
êë
$
‡œÂšžŸ
*+

•–?{@ꛚ›šI
!,EKNIE3
0F0
·Šò¹ºßžÔD‡ò—¢ŠÆ‰Š‹Œ-n
$
Ÿó
ìFŠŽH‰CD8œŠþÿt
! [JI.FG-6IJ,6IGKJ0R3
SEKJRER$@2TR
·Ðýþ
$
ŠÆ‹Œ-nÇÚi~ŽH
@2TR$
êŸóùԝî•–
!
q
4]
š•–؇‚Èž
‡ˆ«£
,EKNIE0F0
™£Ž
$
tÉùÔªó
@2TR
™£
OǕ–*̞[Ðw‹Œ-n
*(+

žï@I
!H63
[-GHE.6,F0
Z[ÐXšŸ>‡ˆ6½¾_Á£
$
IwÏ@
êʂÀ8Ð$t—¢‡œÂ^_
(
ž™Ÿ³ž
Ÿ

•–?{@ê›I‹Œ·Š$ߞ‡ò—¢ŠÆ‹Œ
-n
!
q
4,$
Ï®±Ä{–—I·ÁŽ
$
µîÈ
É
$
šÉáB
<6R32R[3`JJ3QI6
£} Ÿ
!GK6[J0-R-.E
ZF0JRE
¬}$t
!ì’ZI$
>?B%=1-
,L,)3IFZEZF0JRE!>B$t
$
Zš‰Š‹Œº»L¡ 
Ÿ³ª’žŸŽ
*)$+

&M&O
ì0{òž‰Šî()
!@2C32D@@
Ÿó‹Œ
ŽÁÂ*+
!
¢ôq8f
![IJLFE0-IFLE
Z[ÐBB‡ˆ
Â^_‰ŠjM8f¾_Á£
$
•–?{@êÝI—n·
ŠýÈ
$
›I·Š$ÙOߞ
]F-GF0
ŽD‹Œ{ì0{òž
£†¤¥
$
ŠÆž[ÐÂ^_ì0{‹Œ-n
!
q
4L
š
•–;@êìµE0{z_()
$
¦ŠÆì0{‹Œ-n
¬CD8Ž—nµE
$
ê@ê
]F-GF0
ŽD±Ä1ž
©-Ž

µè©îÈÉ
$
šŽÉ§m׌
4] !R[IF,F0USJ,G-K4]$8c4]

4
h8ò
!82@4$
—[
3•–,mœ
$@IJLFE0-IFLE
wÏ68žŸó
82@4$$
—¢Ê
‚
8c4]
ÏÁ£OÇ
$
d)I›CD8ÝìÉ«\
§mÇ}
$
ʂ^_CDÊ`ꇜÂ^_žŸ
*)+

͑
[AŽz쨝*+Z‡ˆ«£©kI
!bNEK,EGF0
Ž
‘’

­ó©kI÷ªØBBì¸-‰Š
$
×®wÏ÷
ª·ŠÉò¹ŠÆì0{¸--n
$
•–?{›IzQòò
¹º@êf_¸-ߞ
]F-GF0
ŽD‹Œ
$
—¢ŠÆì0{‹
Œ-n
!
q
4E
­ó
bNEK,EGF0
¬Ž·Áù
$
›«‘
ì™yŽwÏݏ—nìŽH
$
—¢–—Ž

ˆùÛ(Ÿ
bNEK,EGF0
º
]F-GF0
ŽD±Ä{z_Ž

$
µè©îÈÉùۋô£AìFŠ·ÁŽ

$
stÐuv
P8@%$=P8@($(
¬$t
)
!<_) (
§2À
2T@
t
(
ÀI$‰t•
*))+

&MaO
òóÙÙIŽH
8:C2<
“”‰Š:‹ŒÁ*+
!
CDç­ßàŽsÉÙÙIŽH()
!RGJ]IEFR-G-[EIJ]EIF0U
]6J.F0-J,FLRF0 ,EI,NIGNKE$8:C2<
ZÔøÉߏ;
fg$û5“”

Iì’éÁó‹ôÏ-™£«â$
uÁߝâ_
8:C2<
(){‹ØZŸ‡ˆÙÙ
I
!
®h

¨sÉÙÙI
!
ûh

ŽH[ò\vP{Bç­
ò$[ò$
CDµ
#3
9WPù
$
sÉÙÙIŽH[
ò\Ãw¯ž1CD­Áà$
$
P°{B[ò
RùÛpBBØَHCDÈ‚è•Ž+hÁ
$
µp
fU€‹Çù‘îÈÉ
$
€¢‹ôØÙNj;CD$
uÁߝâ_
*)43)&+

òó®()
$
?Ömœ‡ˆ«£V±@
I
!KJ[J.6,F0
wÏsÉ
5g3GEK.F0JI-IFU-[6KF.FLF0E!T\@
.>;2R
/²
$
st«eÀ{’³×Œ•
$
—¢
ÕÖTACD™;êë
*)5+

®‘òó
8:C2<
•–m
œ
$! h3J>$83
R´+
!96KF,J0-I
wÏ@êìFŠUC
D8÷µ@N€¢ —
GJN
d‚
$
ö~CD8
GJN
*)#+

&M%O
I@“”
!
Gì|þÿ”
*)%+
#
‡ˆ«£
.JKF0-[6K3
K-IE2
BBz~Â^_‰Š
$
•–?{›I‹Œ·Š$ß
ž›BŠò·ŠGìòž
$
ŠÆžGì0{‹Œ-n
!
q
4S
rš‹Œ-n¬Žm™©¶žŸO
$
Gìòž
$ŠòÇÚ¬$[òm™E8
$
pGìòžþÿê
Û®E81º
$
—¢Ýš—nGìŽH
$
ÙOȍ
:‹Œ

­óŽHBBGì†-
$
×¢wÏ@êpf
U€¨Gìý>“ÿ‹Çz_š

µêÈÉ
$.JKF0-[63
K-IE2
ŽÉCD¶·
J,GF0
‰CD›ÀŽH()
*)+
$
+@ê:‹Œ-n݉CD
8Ž—n|íŽH{੝()
$
Ôøqµwχ
œ

IòQ{‹Z
$
@ê›:‹Œ·Š$ߞ…†ò
$
é:
‹Œ-nÝͬŽm™·Á
$
—¢8žBBM¸‡
!,6,I--,G60E
òžGìkK‹Œ
$
›‰CD8
$
-nº…
†òž¬GìkK‹ŒºM¸‡m™
*4 i)+
£¬M8à
¸-
$
àÛ®’E8
$
—¢‡œÝ‰CD8Ž|í
ŽH{à©

aO
òó‰Š:‹Œ·Š0f¸„Á()
0f¸„Á()Z[Ðòó:‹Œ·Šìè—n
¸„ŽW´“”
@HJK.9J[[EK
Z[Aw÷­¹
v›§ºR¥
$
I45@ê,†ž»u”ÈÉ,£‹Œ
žŸŽ

@ê,†ž¼ÁY¥
$@HJK.9J[[EK
wϛ=:
O8Ãàݽ›,£Ž¼Á

›
@HJK.9J[[EK
=ç
N$‹•ž´ê
% $$$
Aòó†À,†ž²h
!
±¾ž
#)%
A,£ŽvÃ
$
st
&5(
?ÀŽ

*)(+
9J[[EK
ZÍ[Ðòó0f,£‹ŒŽ‘’¿à
$

’Ž‹Œò¹ZBB©À·Š_Á£wÇBB©À
ŽžŸ“ÿ
TÁžj:
4$
3BB,‹
OÇxȝ_Á£·ŠÏ¨´ê
4$$
3A·Š°h_
Á£
wŸóxÐ_Á£,‹‰ŠW´
(
,£‹Œ
3
Ž©ªŠ-;
(
0fÁÂÃ/•–•fg

Ôø
$
Õ%á•–fŠqµO˜žjߝ®¾•–
*4$+

Žw230$SÏ81OmŽ=çNÉ«S
$
‹ŒÝ
8“”Éò¹
$
•mž[IzÉÃT0f¸„Á¬
þ
$
Ç*̛§ºR
! HG[# ==KEdEKREL-,Z+dRIEJL+,-.=
IŽ=çNsáž
#$$
AŽ
% $$$
A‰ŠÙèv
Ã

ŸÄÖü*µ:‹Œ·Š
$
¬þ+w@ê:‹Œ¬‰Š
Ùè[[Ý8»u
$
a£¹cø‰ŠÙè
$
W´:‹
,$,
567•
#
‡ˆ‰Š:‹ŒŽ‘’“”•–—˜
Œ½›žŸŽ

®M,ª’›ó=çNãhŠ
$
=
çNŽÉ?³Ž
$
LW·ŠÃT
!
ÌbòŽ’
$
Ž
™£vÃw.
$
stŽ
@N]9EL$V<$B0F@K-G$<28$WKNU3
DJ0Z
•vÃ
$
“,ŸÄ—nùԷЋô

çkƒ
$
B•–
?{#Á(Ÿ
)
и„ÁèÃ/¬þ
!FLTJKUEG
{
@HJK.9J[[EK
Ý$,~ëðÂ^_‰Šà‹O˜ž0
f¸„Á•–

@êÁÂÝ8
(
·Áǝ0{L‹
$
—¢
mœžÅ~ðI
! [F,K-,K-,F0
¬Ðuv
PR[($ JI[HJ
wm™ìFŠ·Á
$
I‹Œf‚wÇZÅ~ðI¬
PR[($3JI[HJ2T@JRE
˜_·Šg$£`A›U[ò
\òžm™0«¸-
$
€¢^‚žšt‰Š—
}
*4+

®‘
$
¼ÞI
! ]JF,JIEF0
BBz~Â±üƞ
Ÿ
$
ÒZIŽØ°h
$
•–?{(Ÿ0fÁ
ŽÃ/M,
$
@ê=çNXY
(
‹ŒÝ8
(
ò󷊝,
†ž¼;
!RGKN,GNKE3]JREL [HJK.J,-[H-KEREJK,HF0U
Ϩ_
©ÀŠ¼;
!,HE.F,JIRF.FIJKFG6REJK,HF0U
•()
$
Â1
ž¼ÞIžŸŽÉÇÈzÝÉòþÿt
!,JGE3
,H-I3J3.EGH6IGKJ0RSEKJRE$<\9T
{¿‹R_t
!.-0-J.F0E
-7FLJRED$92\3D
•–?{—¢,›
;9W2
U
8P8Y5Y
CD²hºˆ¸ž¼ÞIÝCDi|žŸ
$
Ï
¨Ý[R_†{‰ŠR÷­ò^‚žŸ
*4)+

%O
ò󙣣‹“”¾´‡ˆ‰Š:‹ŒŽ
sɊ‡ˆZ™££‹$Žzqӝ[ÐÈÉ
‰Š:‹Œ·ÁŽ“”
$
I‹Œ´çZwЉŠ:
‹Œ{j‹Œm™·Á
$
Ê˭󏐬‰Š:‹Œ·
Áù$Á£â)×8ÌL
$
—¢Ê8žsɊ
$
¬
iǝL·Á©Žd‚ýÂ×Í

×®w@ê´ÉL
,£Ç‹;¬,£Ç‹;wîâ_
$
ˆù—nŽz
$
€¢Î’£Êã,£Ç‹øùuÁßm™ý&â_

$
­®wù3Š‹Iɽ›:‹Œ·Á
$
š(
)t}óÉ,£0{ŽsɊ‹ô
!LKNUJSF0FG6KER[-0RFdE
GJKUEGRGJ]FIFG6$W2>T8
*44+

R¹,B[Ð×­M“”k
ƒ£Ÿ
$
+òóR_ý!sɊ‹ô
!RGJ]FIFG6-S[K-3
GEF0RSK-.KJGER-S-7FLJGF-0$8@>\`
š“”Z@ê´É}
R_[\bòæM—¢$­wǬ:‹Œm™·Á
½›
$
wЉŠ:‹Œ¬f[Am™·Á
$
ìp+
ý⚏Ï…Éí
$
—¢ý⚏£}$[\º
ìFŠR_¸-—ë
$
RT@êî)ÏÈÉ
*4&+

®¾“
”[AvJZ
$
‡ˆ$ü5éŸÁó™‹w:‹Œ_
Á£
$
B§¨ÁÁ
..-I,C
h
–’
$
×®I‹ô·ÐZw
ÇÚXÓ¸¹™‹É펝{:‹Œ ©¶žŸ,
B3—[3P×

#O
òóª’?³v<@N‘’‡ˆ‰Š:‹ŒŽ
i‡ˆ‰Š«£žŸf‚•–Z>óÝI,Ÿ¢
£QªWþ-Ÿ¢O˜
$
+óPAr$ÝfA¢£,
ŸO†HFiwǛI*v£$B—Àœ

-«wÏKç
Ôøq‡nݚ¾?³‹Œv<@NžC
$
Ð3-;š
‰Šà‹wǝžŸŽ

VDѝWþO†stÒ
º~Ó
(
@$å)
(
Ô^å)•
$
cdºŸóº»¾ºÓª_
X•]

VDÑ8f
!GKF[G-IFLE
Z[зŠÞìôn¾‡
ˆ‰Š‹Œ
$
BBÂX
(
`aʂ
(
Â^_•‰Š
)
ÒZIB
ÀžŸŽÔøeØö•

­óº»ÂX™£‰ŠžŸ
[†¬X]þÕ׌‰Š^‚3m©ª
$
×®òó®¾
Ö´
$

,
ØÙüÚj•–?{¬þF•–ž
GKF[G-I3
FLE
ÝCDþ՝ØÙÛÜ{Q¬|AÛܝØÙONJ
^‚žŸ

RTmœ
GKF[G-IFLE
ÂXžŸ‹ŒŽZ
þÕ׌
Tc:P

@`D=V><<4


€¢É
GKF[G-IFLE
Â
X‹Œf‚¯°*̞û5‡ˆvÃ
*45+

(O
I@­“”
”eòÛÜݚI
2!UIN,-[FEKF,FLF0 2$Q@2
Z[Э
§š«™ÇÚʂq™£aÉÞ]%Ä
!SFI-[-LFJ
[K-GKNRF-0
‡ˆ‰Šà‹
$
{Qû(ŸPr;“”•
–ž
Q@2
žŸŽ

@êÍCöU€
3
7nO î
EŸ()
!š•–žŸmœ
Q@2
Çڍ„ž
Ÿ”ßeþüÀ—¢Ê‚eà‚êë
$
×®
Q@2
wϞÉ
[Ðeà‚‹Œ-n8ÏéŸ

-Z[A(ŸPr;
‹ô“”ÈɋŒŽ%á*+
*4#+

HXš9–
Pr«£
6`I-ZEGJID! _`D
BBý&ÂR_
(
âµi|
(
Sâi|žŸ
$
ÒZIžŸŽ¨Pr^‚žŸeØ
ö•

•–?{pãÁäå
!.FLJX-IJ.
žÉ²h‹Œ-
n
$
(Ÿ™£vÿàM,
WW:3<@:![KELF,GF0ULKNU3LKNU
F0GEKJ,GF-0 dFJ,HE.F,JI3[K-GEF0 F0GEKJ,G-.E

_`D
žŸ
ŽÉ
<6[4J)$
êПÙ>Ʋ{‹ŒÝ8()•–ž
_`D
¬Ž
<6[4J)
7 ©¶žŸ
$
—¢@ê
W2A:W
¿à
! LJGJ]JRES-KJ00-GJGF-0$ dFRNJIFXJGF-0 J0L F0GEUKJGEL LFR3
,-dEK6
‹ôžò󚍎
_`D
v<^‚@N

·Ð
mœž
4)&
A½›ŽÏ¨
#)
ßv<@NwÇ}
_`D
—^‚
$
ÙO,mœ
_`D
wÏý&Ž^
@&5$ 4J
!<6[4J
8áMà{‰Š{uÁæM
*4%+

$O

‡ˆ‰Š:‹ŒŽ‘’Z‡ˆ,£{­,
•mfgû5(J

ò󇈉Š:‹ŒwÏ-;êm
œi·Š{OÇÞì,£Ž
$
€¢ÉùÔòó
Ž·Šc­,£œ*̪’‹ŒvÃï

­
󇈉Š:‹Œ·Š›‹«
$
×®›—nŽ‘’
êë$̔ПLɝ[Г”
$
[†Z#ÁPÄxÐ×
I
$
Žw
#
‹Œ·Š­MŠ
(
‹Œ_wABŠ
(
‹Œæ
‚Š
(
™£‰Šj:•ÐïŽ
$
/v[ÐRÉÁ靓”

×®Q^tÝø»çГ”%/—nž#ÁŽz
$
Ó
u

‡ˆ‰Š:‹ŒŽ‘’wÏÉùÔў-;-ã
:‹Œ¬Ž©¶žŸ“ÿ
(
žŸÙè
$
Ϩ‹Œ
,,
)$#
y

z ˜
&
™˜

}
A-I?&$ ;-+ MJ0NJK6$ )$#
!!
u
!
Ÿó‘’‡ˆ‰Š:‹ŒŽxГ”Žz
TJ]IE!WFSEKE0G.EGH-LRS-KFLE0GFS6F0UGJKUEG[K-GEF0R-S0JGNKJIJ,GFdER.JI.-IE,NIER
“” () ()àJ -ŸÀ¬ Ž‚ôÑ ì¨5Â
`a0{>î
!

#
‡ˆ$ü5iӏ‰Š
$
‹ô·ÐO5B
†è~é¡ê
)
Ý,£è‚È›‹Ñž
àJ
!
À‘
!!
Ñ _Á£·ŠüwAB
‰Šî
!

#
ü5;()M,¨BfÁàuÁ
$

Ï-
$
ëŸÁ
)
Ý,£è‚È›‹Ñž
àJ
!
À‘
=
À8 Ñ _Á£·ŠüwAB
0f¸„Á
!
$
#
M,ŠÆzÉ4ì
$
Òw—nÁ@ßÃ/
$

?}
)
0·Ðü5›CD¨|£æMˆ¸

!
0¿à $ ü°hŽ·ŠvÃ
™££‹
!
$
#
(ž–ëLÉ
$
†_Á£·ŠÕÖz:
)
җm
œžŸèwÇìFŠz)

!
À‘
!!
$ üéŸÁwÂ:‹Œ
?³v<@N‹ô
!
t
#
(ž–ërt
$
Òü5jßîï^`Á•–
mžè
)
Ïmœc­h,£è
ØàJ À‘
!!
š üjß^`vÃ^•
f‚•–*̪’ŠïvÃ
$
S`ÏSÔF‡nÝV
=µ1?³v<@NO˜,‹•–ð³

Xӑ1݉
Š:‹ŒßÀñò
(
Ì󄊝,‹f‚•–

ÙO
$
­ó
CD8w¬:‹ŒžŸØå[A
$
×®twÏ@ê-
ã()‘’¬:‹Œm™©¶žŸA
$
—¢$­w
ǝ,£EŠŽ¨ôžŸ
$
—¢w.ž‚,£‹Œ,‹
¨E‹f‚

u7
$
‡ˆ‰Š:‹ŒžŸŽ‘’Z[
B›‹BB“¤Šgž
$
©ª•–()zë?
$
ü5•
–ûµˆzÉ®±
$
õ‰”ùÇÚ£œ××8àJˆt
óë?“”
$
€¢é)šB•–Çڛ׿…è8O
˜
$
jj¾|‡ˆ,£¨­,•‚ø—3ö


tu?v
#
* +!BKRN 2$ aJIL.J00 P?PFLEJ0L REEZ# FLE0GFSF,JGF-0 J0L ,-0SFK3
.JGF-0 -SR.JI.-IE,NIE[K-GEF0 GJKUEGR*M+?DF--KU9EL CEG$ )$5$ )5#4$%(?
* ) +!9ELdELEd2$ _-[6I-d2$ DN0EEdJ\$ EGJI?2SF0FG63]JREL [K-3
GE-.F,[K-SFIF0U# [K-]IE.RJ0L J,HFEdE.E0GR*M+?@K-GE-.F,R$
)$)$ )##)?
* 4 +!>F7B$ 8N[EKGF3cNKUJQ?TJKUEG[K-SFIF0U-SR.JI.-IE,NIER]6
,HE.F,JI[K-GE-.F,R*M+?;JG* & +!8J7E0J<$ PFUUR>V$ OHE0 V$ EGJI?8.JI3.-IE,NIEJSF0FG6
,HK-.JG-UKJ[H6,-N[IEL .JRRR[E,GK-.EGK6S-KLKNUGJKUEGLE,-03
d-INGF-0*M+?V7[EKG\[F0 WKNUWFR,-d$ )$$($ &#%$?
* 5 +!8JFG-H T$ TJZEFKF9$ Q-G-H Y$ EGJI?WERFU0 J0L R60GHERFR-S]F3
-GF06IJGEL WP9V^ S-KLFKE,GFLE0GFSF,JGF-0 -SFGRGJKUEG;c3
1
D
,-.[-0E0GR*M+?DF--KU9EL * # +!RGKE[GJdFLF0 JSF0FG6R6RGE.R*M+?)##?
* % +!CFN < $` YF0 ^ $^ OH-N P<$ EGJI?2LE0J0GHF0 GJKUEGR[EK-73
FKEL-7F0
/
J0L
0
G-F0LN,ELFSEKE0GFJGF-0 -SIENZE.F,,EIR*M+?
;JG* +!P-N M_$ PNJ0UY$ PEa$ EGJI?2LE0J0GHF0 GJKUEGR[EK-7FKE3
L-7F0
/
=
0
G-ZFIHE[JG-,EINIJK,JK,F0-.J,EIR*M+?WFR$ )$&$ 5#E&$$?
* ( +!W-0UT$CF<$aJ0U` $EGJI?2F0RIFJLF.EK2REIE,GFdEI6F0HF]FGR
:__

G
!
]6,-dJIE0GI6]F0LF0UJ,-0REKdEL ,6RGEF0E*M+?;JG
<-..N0$ )$5$ ###5))?
*$+!CF<$ W-0UT$ CF^ $ EGJI?@K-]F0UGHEJ0GF,J0,EK.E,HJ0FR.-S
! h3JF0RIFJGKF.EK2 GHK-NUH LFdEKGEL G-GJIR60GHERFRJ0L
]F--KGH-U-0JIIFUJGF-0*M+?20UE*)?
*+!DJKUJU0J39-HJ0 @$ PJ.XJ2$_F.YV$EGJI?THEGN.-KF0HF]3
FG-KJ0L J0GFJ0UF-UE0F,JUE0G*FGHJSEKF0 JGJKUEGRGHEF0GEK.ELFJGE
SFIJ.E0G[K-GEF0 dF.E0GF0*M+?*)+!YJ.J-ZJ9$ 8JG-_$ _-]J6JRHF9$ EGJI?20GF3H6[EKIF[FLE.F,
JUE0G0E*c>%%4($ JSK-.8EKJGFJ?:A?TJKUEGFLE0GFSF,JGF-0
J0L dJIFLJGF-0 ]6,HE.F,JIUE0EGF,J[[K-J,HER*M+?M20GF]F-G
!T-Z6-$ )$$5$ 5##5&?
*4+!CFN C$ PNJY$ aJ0UW$ EGJI?2RERbNFGEK[E0EIJ,G-0ESK-.J
.ELF,F0JIHEK] F0HF]FGR[K-F0SIJ..JG-K6J,GFdFG6-ST;c3

]6F03
HF]FGF0UN]FbNFGF03,-0/NUJGF0UE0X6.EB],P5 *M+?)$&$ )#4&?
*&+!cFK-NXFO$ CJKF@$ >JRHELF0FJ9$ EGJI?@K-GE-.F,RR,KEE0F0U-S
.-IE,NIJKGJKUEGR-S,NK,N.F0 F0 .-NRE]KJF0 *M+?CFSE8,F$
)$&$ (#)?
*5+!CEE8 Y$ CF.TQ$ JGF-0 -SHN.J0 ,-I-0 ,J0,EK,EIR]6LFKE,GI6GJKUEGF0U
!
3,JGE0F0
*M+?@KEd>ER!@HFIJ *#+!8JZJ.-G-8$ PJGJZE6J.J9$ :G-T$ EGJI?T--IRJ0L .EGH-L-I-3
UFER,J[J]IE-SFR-IJGF0UJ0L FLE0GFS6F0UJGJKUEG.-IE,NIES-KJ
]F-J,GFdE,-.[-N0L *M+?DF--KU9EL *%+!aFIE.RC:$ \dEKZIEESGP8$ dJ0 _JRGEKE0 8 :?.E0GRF0 J,GFdFG63]JREL [K-GEF0 [K-SFIF0U*M+?DF-,-0/NU)$&$ )5#?
*+!DJGE0]EKU\2$ YJ0UY$ AEKHEIRG8 P$ EGJI?TJKUEG[K-SFIF0U-S
&3H6LK-76LEKF,F0 F0 2? $=%=.KEdEJIRREK6I3G>;2 R60GHEGJRE
]F0LF0UJ0L F0HF]FGF-0 ]6,-dJIE0G.-LFSF,JGF-0*M+?9-IDF-R6RG$
)$4$ (#4&4?
*(+!OHE0UD$ OHN 8$ aN ?`,HE.F,JI[K-]EG-E7[I-KE[K-GEF0 [JI.FG-6IJGF-0*M+?2<8 DF-I$ )$5$ $#5?
*)$+!;FRHF0-9$ ,),
567•
#
‡ˆ‰Š:‹ŒŽ‘’“”•–—˜
SN0UJI0JGNKJI[K-LN,G$FLE0GFSFERGHEKJ[ENGF,GJKUEGRF0 >%:#$().)K
$ B%=1-*M+?VIFSE$ )$4$ )#E$$%)?
*)+!_-GJZEY$ 8JUJ0E_$\*JT$EGJI?8[IF,F0USJ,G-K8c4] JRJGJK3
UEG-SGHEJ0GFGN.-K0JGNKJI[K-LN,G[IJLFE0-IFLE*M+?;JGDF-I$ )$$%$ 4#5%$?
*))+!aJ0U>V$ PN0G<>$ J0 F0GKF0RF,[H-G-JSF0FG6[K-GE-.F,R[K-]ES-KGHEFLE0GFSF,JGF-0 -S
bNEK,EGF0 GJKUEG[K-GEF0R*M+?DF--KU9EL &%$?
*)4+!WFG.JKQ$ 8EI]J,H 9?8:C2GE-.F,R*)&+!P-ELGV$ OHJ0UQ$ ;EN]EKGT2?8GJ]IEFR-G-[EIJ]EIF0U]6J.F3
0-J,FLRF0 ,EI,NIGNKE!8:C2< S-KbNJ0GFGJGFdE[K-GE-.F,R*M+?
2LdV7[ 9EL DF-I$ )$&$ $##(4?
*)5+!PN-Y$ :JLEdJFJA$ YJ-O$ EGJI?8GJ]IEFR-G-[E3IJ]EIF0UJ0JI63
RFR-SGHEF.[J,G-SF0HF]FGF-0 -SGHE.J..JIFJ0 GJKUEG-SKJ[J.63
,F0 -0 [K-GEF0 R60GHERFR*M+?DF-,HE.M$ )$)$ &&&#&?
*)#+!9JKGF0 9W$J0JI6RFR$ J0L LEKFdJGFXJGF-0 -S.6KF,J0-I[K-dFLE0E*[K-]ERGHJG
[K-.-GEJNG-[HJUF,GJN ,IEJKJ0,E*M+?2<8 $#$((?
*)%+!PNUHER<<$ YJ0UYC$ CFN aT$ EGJI?9JKF0-[6K-IE2GJKUEG
EIN,FLJGF-0 ]6J,6IL6EGKJ0RSEK*M+?M2.4#)$(&?
*)+!DJRZF0 M9$@KER,HEKM2$CJNUHIF0 8 T$EGJI?<-[[EK3SKEE,IF,Z
,HE.FRGK6S-KL60J.F,-( 9-9)F.JUF0U*M+?@K-,;JGI2,JL 8,F
B82$ )$$%$ $&##%(4?
*)(+!CFN $`\N6J0U8$YN D$EGJI?@HJK.9J[[EKREKdEK#J*E] REKd3
EKS-K[-GE0GFJILKNUGJKUEGFLE0GFSF,JGF-0 NRF0U[HJK.J,-[H-KE
.J[[F0UJ[[K-J,H*M+?;N,IEF,2,FLR>ER$ )$$$ 4#a#$(?
*4$+!Q-0UM$ EKS-KE7[I-KF0U[HJK.J,-I-U6J0L ,HE.F,JIRGKN,GNKEJRR-,FJGF-0
]JREL -0 .-IE,NIJK4WRF.FIJKFG6.EGH-L *M+?DF-F0S-K.JGF,R$
)$4$ )(#)%?
*4+!DHJGJ,HJK/EED$ AF/J6JRJKJGH68$ _JKN0JZJK@$ EGJI?<-.[JKJ3
GFdEKEdEKRER,KEE0F0UJ[[K-J,H G-FLE0GFS6[-GE0GFJIJ0GF30E-[IJRGF,
GJKUEGR-SRJSK-0 SN0,GF-0JI,-.[-0E0GRJ0L ]F0LF0U.-LE*M+?
2RFJ0 @J,M*4)+!QJ-C$ cJ0UM8$ DJF` Y$ EGJI?:0 RFIF,-GJKUEGSFRHF0US-KGHE
[-GE0GFJIGJKUEGRJ0L .-IE,NIJK.E,HJ0FR.R-S]JF,JIEF0 JRJ0 J03
GF[JKZF0R-0FJ0 JUE0G# LFR,-dEK6-SGHE[K-GE,GFdEESE,GR-0 ;9W2
KE,E[G-K3.ELFJGEL 0ENK-G-7F,FG6*M+?# #%5?
*44+!C-.E0F,Z D$ PJ->$ M-0JF;$ EGJI?TJKUEGFLE0GFSF,JGF-0 NRF0U
LKNUJSF0FG6KER[-0RFdEGJKUEGRGJ]FIFG6!W2>T8*M+?@K-,;JGI
2,JL 8,FB82$ )$$($ $##)(&?
*4&+!aERGQ9$TN,ZEK[K-J,H S-KFLE0GFS6F0U[K-GEF03LKNUF0GEKJ,GF-0RF0 ,-.[IE7.F73
GNKERNRF0U[K-GEF0 RGJ]FIFG6.EJRNKE.E0GR*M+?@K-,;JGI2,JL 8,F
B82$ )$$$ $%#($%?
*45+!TFG-dWA$ QFI.J0 D$ PE^ C$ EGJI? @`D$ JRN]N0FG-STc:P$
FRJGJKUEG-SGHE0JGNKJI[K-LN,GGKF[G-IFLE*M+?;JG)$$ %#)?
*4#+!_FGJUJ*J9$ :ZELJ8$ TJRHFK-V$ EGJI?9EGJ]-I-.F,FLE0GFSF,J3
GF-0 -SGHEGJKUEG-SGHESFI-[-LFJ[K-GKNRF-0 F0HF]FG-KUIN,-[FEKF,F3
LF0 2*M+?*4%+!8N M$ [-N0L$ J,GR-0 J0EG*-KZ -S.-IE,NIJK[K-GEF0RJ0L KEUNIJGERGHE
J,GFdFG6J0L E7[KERRF-0 -SKJG,6G-,HK-.E@&5$ 4J# J]F-F0S-K.JGF,
J0L J0F.JIRGNL6*M+?WKNUWERWEdEITHEK$ )$&$ #)555?

wx-0
!
€
#
,4,