免费文献传递   相关文献

Study on contribution of main components in Guizhi Fuling capsule based on molecular imprinting technique and activity screening

分子烙印-活性筛选结合评价桂枝茯苓胶囊主要成分活性贡献度研究



全 文 :)$5
x
#
y ÿ
&$
!ÿ
)
|
X-RL&$$ ;-+) VW0C$ )$5
Üɤh
3
[Á¥¦÷ø§!¨©ª«¬­
®¯€Ü[Á°±Õ†‡
CDE
!)
!
ÑF
!)
!
ƒ&&
!)
!

!)
!
CG
!)
!
ÑH
!)
!
-|«
!)
!
¬ 
!)
!
L
¶ƒDE~’FGÍÎÏÐ
!
¶ƒ HBI
)))$$%
)L
«~å~J/ÅÆI䀚›œ
!
¶ƒ HBI
)))$$#

op
#!
6L|Ó¨©ª«¬­É»ilÁîB
%
¶#êɄ•d…®¯,‹€Ü
$
1†‡Ö×Üɤh()h¨©ª«
¬­$®¯€ÜêÕ%ã
!
Üá%ã
$e$4$e$5$e$%$e$($e$$$e
î
$
ÜákMvɄ–—
%O@8
·©
>2Y)#&L%
’b
G;I3

%
:z Z[þÿ
!8@O
wxÉ„•dþÿwx‹krYÚ¨©ª«¬­[Á…¸_‡ˆ
*
÷A†|
$
#êÕ%ã:
,i
%
~ªSêO,ùi
$
¨©ª«¬­Z MvɄ–—›œŠ³Ñ
+
$êÕ%ãP…ɳ
%
¨ª
%
ÅP…ÉâÎϦ
ꪫé¦
$
¨©ª«¬­Z 
G;I3
’b›œŠ³Ñ
+
%êÕ%ãP…ɳ
%
:,i
%
¨ª
%
¨ª—ꪫé¦
$
¨©ª
«¬­~
8@O
þÿwx›œŠ#Ñ
+
&êÕ%ã:,i
%
~ªS
%
ÅP…ÉâÎϦê:i
$
¨©ª«¬­ üv:Z 
Ʉ•dþÿ…›œŠ#Ñ
*
1†‡D¤
$
rù€Üü˜$¨©ª«¬­lŒÉ»ilÁîB
%
¶#êɄ•d›œ…
#¯[ÁÖþ
*

qrs
#!
¨©ª«¬­
+
Üɤh()
+
Ʉ–—
+G;I3

+8@O
þÿ
+
Ʉ•dþÿ

tu)(
#!)$53$)3$&

vwxT
#!


€r~Õå
(
£Å€r÷†
)$4_^ $(&$))$4#

yzA{
#!
!
¬ 
!
‘¡ðêRêÄ/—
!
‘¡è¥¦«~~9‘¡©Ì{
!GCR$ $5#5)44%!?3.SPR$ *\D\D30/1#4L0CQ

A{‚ƒ
#!
CDE
!
34‘¡ð
!
‘¡è¥¦«~~9‘¡©Ì{
!GCR$45&$4)&(!?3.SPR$ 6-W0NECT(1D-Q.SPRL,-.
>0=/? 13G1302-;=0-1317+,-3G1+:136309-3F=-T5-C=.-3M G,:9=.6;,96/
13+1.6G=.,2-+:2-30-3M 06G53-P=6,3/,G0-I-0? 9G2663-3M
<2A_C36W
$)
$ F:;HZWC
$)
$ 8`_DC03\DC0
$)
$ O:;S
$)
$ <2AOPS0N
$)
$ F:;HHS0N
$)
$ Y2;H_DC03\D-0N
$)
$ :^2AYCP
$)
!
!LT$(.+* D($& !0(#1(#%*4$%(-,&L$ E4;L$ E$(2*.(. )))$$$ ,0$(+
)L34(4D2E(A&#(4&/I5<4%0 /&#,0$+);$%$!0(#1(%*4$%(-!#&%+$ E$(2*.(. )))$$$ ,0$(
,A;902,G0-!G-,RSTP[6QDCS,QPdC,-.K-0C0QJP0 HWP\DPIWRP0N,SKJWRCP0 QTCSQ.C0Q-[P0QTP0JP,U6J.C0-TDCS$ KCRdP,P0[RS..SQP-0 S0U
D6JQCT-.6-.S$ .SP0 ,-.K-0C0QJ*CTCNTSUWSR6E0-,ECU -WQ[T-.QDC,SKJWRCJ$QDCC[C,QJ-[E0-,E-WQ,SKJWRCJ-0 WQCTP0C,-0QTS,QP-0$
G;I3

JC,TCQP-0$ .WTP0CJKRC0-,6QCJ!8@O S0U D6JQCT-.6-.S,CRJKT-RP[CTSQP-0 *CTCCdSRWSQCU$ TCJKC,QPdCR6LGDCP0DP]PQP-0 -[,SK3
JWRCJ-0 WQCTP0C,-0QTS,QP-0 *SJ*CSEC0CU ]6NTSUPC0QE0-,E-WQ-[KSC-0P[R-TP0$ KSC-0-R$ S0U S.6NUSRP0LGDCJWKKTCJJP-0 -[,SKJWRQC
-0 G;I3

JC,TCQP-0 *SJTCUW,CU ]6NTSUPC0QE0-,E-WQ-[NSRP,S,PU$,P00S.SRUCD6UC$ KC0QSNSR-6RNRW,-JC$S0U KS,D6.S0LGDCKT-.-3
QP-0 -[8@O,CRJKT-RP[CTSQP-0 *SJTCdCTJCU ]6NTSUPC0QE0-,E-WQ-[NSRP,S,PU$ KSC-0P[R-TP0$ ,P00S.SRUCD6UC$ cWCT,CQP0$ S0U KS,D63
.S0LGDCUCKTCJJP-0 -[,SKJWRCJ-0 D6JQCT-.6-.S,CRJKT-RP[CTSQP-0 *SJSQC0WSQCU ]6NTSUPC0QE0-,E-WQ-[KSC-0P[R-TP0$ KSC-0-R$ KC03
QSNSR-6RNRW,-JC$ S0U SR]P[R-TP0L:0 ,-0,RWJP-0$ QDC,-.K-W0UJ.C0QP-0CU3S]-dC,-WRU ]CQDCEC6S,QPdC]SJPJ-[HWP\DPIWRP0N,SKJWRC
P0 QTCSQ.C0Q-[P0QTP0JP,U6J.C0-TDCS$ KCRdP,P0[RS..SQP-0 S0U D6JQCT-.6-.SL
,]6? N12/9-!HWP\DPIWRP0N,SKJWRC+ .-RC,WRSTP.KTP0QP0NQC,D0PcWC+ WQCTP0C,-0QTS,QP-0+ G;I3

+ 8@O,CRJ+ D6JQCT-.6-.S,CRJ
/1-#!& %^(_EGQG++&!#!Y&
.$)&).
Ìí·R
#
Üɤh
3
[Á¥¦÷ø§!¨©ª«¬­®¯€Ü[Á°±Õ†‡
!!
¨©ª«¬­®¯á¨©
%
ª«
%
ˆ~ª
%
Êù
%
:R
5
¢,ß®€
$
®ÉilÁîB
,-
%
¶
#
,)-
êɄ•d
,4-
*
½¾ò܆‡†|¨©ª
«¬­BZ :zMvɄ–—
,&-
%
Z #žÈ
É
G;I3
’b
,5-
%
~¡:z XY]“þÿwx
,#-
êv:Z Çdþÿwx
,%-
R[Á
+
jF
$
¨©ª
«¬­…,‹ÄmÖþzâ|Ó
*
Üɤh()$[åB Õ¦qÁ…(
)
,-
$
üœ×[Á€ÜÜM†‡
,(3$-
*
†‡†
|
,3-
$
P…ɳ
%
:,i
%
:i
%
O,ùi
%
¨ª

%
W¨³
%
~ªS
%
¸Sâ:,i
%
¨ª—
%
ÅP…
ÉâÎϦ
%
úI—
%
ª«³
%
pUª«³êpUT
ˆ³R$¨©ª«¬­Ãi,߅®¯„e}’€
Ü
$
ü˜ž,‹]“
*
6¡[³|Ó¨©ª«¬
­…®¯[Á€Ük ü³v$…°±ÀÏ
$

‡ˆœÜɤh()
$
êÕ%ã ü$…SÌ_ø
Ä
$
–÷ø¦q®ÉÓož]“…[Á¥¦‹k
$
§3¨©ª«¬­[ÁÞ¸‡ˆ
$
9F6 ü…,
‹ÄmÖþac†‡ÈHÖþ
*
!O
ßü
G8_3$&
kMvÀs”ë”ä
%I8H3$
kQŽW
…°
@-*CTOS]=J
éŽeÖ
!
¸³
2F:0JQTW3
.C0QJ$8Y3ký×(›ØÏàrHäâĉ
BCDEA»ÑFà
+4
k
)
±DZ
!
Û%
GDCT.-8,PC0QP[P,+:0[P0PQC9)$$ @T-
kuÌÖ
!
Û%
G?<2;+<$)
kþÿàïù=Ö
!
Û%
:0dPQT-3
NC0+2RCNTS#&>
kØ6 A0|MSŸ
!
Û%
BC,E.S0+#54
k
a3GAI
möÖ
!
Û%
2NPR0CQ+
F2>G8X@
ÄO6ŸÜÝMÉ>
!
Û%
:-0 8C0JC*
¨©ª«¬­áw:ü^,‰ƒ-BCDE
d
!
€<
)$4$$
{—¬­é@
4$ .N+
¸S³
Ç´ë012ÏàÏM¡mgÖ³BCDE
+

ɳ
%
:,i
%
¨ª
%
~ªS
%
O,ùi
%
pUª«
³
%
W¨³
%
¸Sâ:,i
%
ª«³
%
¨ª—
%
ÅP…
ÉâÎϦ
%
úI—
%
pUTˆ³
%
:iꪫé
¦Ïà$%…ä,äH†‡2
* F9?9
±DÖ
%
>@9:3#&$
±DÖêƒV„â
!IB8
Ïà
HP],-
D
E
+
… u Ï à
BP-Q-KKCU
D E
+
ö C E —
I)

!@HI)

%
£é¦
!O@8%
O¾—
%
̾—ê
:

iuÏà
8PN.S
DE
+
:z
G;I3

?O:82
#Èü
DÏà
CBP-J,PC0,C
DE
!
€<
$#(5$$$9G8
þ
ÿHÑwx#ÈüDÏà
@T-.CNS
DE
*
žŽÈ
üÄ6%dÜÝk
*
ÇÁâ<Ä
B2OB=,
:z
! k)) N$
Ïà9
3$A,æĞïÄ$S
$
èüÒ<
8<^ b!
:

)$$)3$$4$
øGÒ<
)$&$)$$*
:zÔÝþÿ
!>2Y)#&L%
Ïà$%&2ô
k±DęÐ$SrHþÿÕ
*
O
´,
X!O
Üɤh4…v\e
!5$$
S+Såæ4

!
O†Hæ_ÈüDE

íÞk
) .-R.O
n
M$
$#5 s
ˋ‰Î[_
& D$
;͉NÍØòî·
7
*
E
5$ N
[_…4
$
,c
5$ .O

%5 .O
L
µ¥Öµ¹Ö˜`
%$L5 .O
Lµ¥ÖgµÖ˜`
$
Uœ¹,w.ëNo
%) D$
ŒUNÍØò4îX
+78
*
XO
Üɤh@€Ü%ã
!
I:,i6º
$$L
N
v\e…Üɤh4
%& ..-R
Œ¹âã
% ..-R
:,i
!
‹©ÜÉ
%( .O
TUº™
%&$ ..-R
µ´
ë´S֌¹³¶ê
))L$ .N
Ÿö´_‹¸k
&L#
..t5$ ..
$+⻕Âö@$w^
$
öJhî
œC
$#$ s
ˋ‰Î™ø
)& D*
Üɤh@§cI

3
ì³
!({%

%

3
Lµã
!({%

3
ì
³
!({%
SëòÜîX+78Fœ
*
Eø–íî
2
$L) O
tÜɤh@
$
–Tëî2ã—78
$
ø–
ª«Üîܟ —
$
£D:,i
$$e
%ãÀ@ä
*
ôj†

$l¤mÑ,c:,i¹jä
$
£D
$e$4$e$5$e$%$e$($e
%ãÀ@ä
*
žŽw_
øą%ã@äÄôj5´,lù F
!
Ã<ً
©ÜÉ
*
ª«é¦á×k üth$6Ÿ¿Ü
ü
$
ÈGô†

l¤mэü£D]o%ãÀ
*
Ü
Ÿm—O
$
,cIܲ@äX%ã1܅mÑ
$
I
™ÒwÀ@ämÑ[ä
*
XYO
,2¡ 
!
¸Eg¿À%ãÀ¬­,Ü
&$
.N$
vì×
&$
)
O
´SÖª¼
!F98A
$
$
ef‰
ñDÖĒþ
$L& N.O
n
!
(›ãÕ
*
X%O
@äÐÑ#H
!
®œ¸E¬­,Ü
$L)5$ N$
5$e

)5 .O
ý§ìÙ
4$ .P0
îtñ
$
ñ2›6
¨ª
%
úI—
%
W¨³
%
¸Sâ:,i
%
ª«³
%
¨
ª—
%
pUTˆ³êpUª«³…9Èì2
$
ñ2B
5$e
SëĒ
$$
¬î›6P…ɳ
%
:,i
%

S
%
O,ùi
%
ÅP…ÉâÎϦê:i…9Èì
2
*
E
$
)
O
@äÄ^Fk¥Ý@½$S
$
ß
‹wŒ7î
$
U×@äWW°r¡m
F2>G3a3GAI3
.)&).
)$5
x
#
y ÿ
&$
!ÿ
)
|
X-RL&$$ ;-+) VW0C$ )$5
!!
†
!5
Q€ÜkwÀ¬­$…ÐÑ
GS]RC!GDC,-0QC0Q-[5 ,-.K-0C0QJP0 UP[CTC0Q,SKJWRCJ .N
_øÄ g¿À
$e

4$e

5$e

%$e

($e

P…ɳ
)L%) )L&55 L($ L4#& $L $L)%4
:,i
#L(%5 #L)% &L4 4L& )L$(4 $L#(
¨ª
$L#)$ $L55 $L&4& $L4$ $L# $L$#)
~ªS
&L&44 4L(($ 4L$4 )L)% L44$ $L&&4
O,ùi
#L##5 5L((( &L### 4L444 )L$$$ $L##%
úI—
$L&$4 $L4#4 $L)) $L)$) $L) $L$&$
W¨³
$L $L&( $L4)# $L)44 $L&$ $L$&%
¸Sâ:,i
$L# $L% $L#$ $L&4& $L)#$ $L$%
ª«³
$L)& $L))4 $L%& $L)& $L$%& $L$)5
¨ª—
$L#) $L#& $L&%% $L4& $L)$5 $L$#
ÅP…ÉâÎϦ
4L5$4 4L54 )L&5) L%5) L$5 $L45$
pUTˆ³
$L%%5 $L#( $L5&4 $L4 $L)44 $L$%
pUª«³
$L5)% $L&%& $L4#( $L)#& $L5 $L$54
:i
)L5) )L5#% L((# L&)# $L5# $L)5
ª«é¦
&(L4) 4&L4(& $&L5) %&L##& &&L%( &L(44
98
#
* F2>G
îï
#
:J6¼J
$
‹Õ
&5$ s$
U
Q
45$ X$L5 ..t($ ..
;½˜
$% ..t$
½¡
¢‹©
$
WWAÕ
$L) ...J
n
* a3GAI
möîï
#
g{Mɋ6
$
pþ˜UQ
$$$ X$
78J‹Õ
45$ s$
78JëA
4L5 O..P0
n
$
†Ä¾1¡UQ
)5$ X$
[
%
´ÄmöhøÜr
1KC
Ä6
5$ k $$$$
56˜
$$5$)$ X*
ãO¡ 
&
Q_øĹjä
ì2
$
:Ì, ›ÌXÚÛ
*
X#O
:zMvɄ–—†‡
!
ÇÁ
B2OB=,
:z
¤×
4 U $?
¸S³Ç´ë
$ .N.EN
n
$
ã³É„;
|–w,
@HI)
„…Á
*
ÿ
&
ÏE:zɄ
$
e
f‰âòîU×
G8_3$&
kMvÀs”ë”ä$
$
”
ë$Ð
4% s
ef‰
$
ãO@c
A
)
3)
wøJ
!({*
þÛÜá÷“É„îם‘À(×
$
É
„î×VHk”ëç1…VH:¿r
$
(פ
Ÿk
I8H3$
kQŽW…°r
$
@ts†ÅÃ,:

N

!$ .;$
Ʉàl†ó€ÍîBÁĞ
*
@-*CTOS]=J
éŽeÖ,²É„…•QŽ
!.;$
±ÖÛÈ­î
$$L4
)
.-R.O
n
@HI)
 <Ʉ
!
{
‹
$
,²É„•WQŽ
$ .P0
îî,
!$L& N.
O
n
$
“,²É„•QŽ
$ .P0$
ùëZ É„–
—I
v!
{‹îQŽ
n
î,îQŽ
=
{‹îQŽ
t
$$e*
ĞFÜ

À
$
Üá6‹kÀ
!
{‹î2î
ôef‰
$
g¿¨©ª«¬­À
$$e$4$e$
5$e$%$e$($e
%ãw_øÄÀ
$

$
›:z
*
X(O
v:Z 
G;I3
Üq†‡
!>2Y)#&L%
þÿ
ô
) t$
&
=
½Ÿå×
(#
½©
!
Ð
$e IB8
…
F9?9
±DÖ
$
±D
)& D
îúrâ
$
{½,c
$$
)
O
Ð
„â
F9?9
±DÖ
$
Ù×±D
)$ D
îúrâ
$

,c
(
)
O
Ð,±DÖ
!
(›ãÕ
$L& N.O
n

à
*
D
î
$
,c
)
)
OO@8!
7ãÕ
.N.O
n
$

ä[6
)$$
)
O$

5
Qͽ
+
›œ
)& D
îE
$$
)
O

$
ôN|qlù³Ï#
G;I3
ÐÑ
$
ùë
Z I
v!
‹kÀÐÑ
n
@äÀÐÑ
=!
‹kÀÐ
Ñ
n
+ÀÐÑ
t$$e*
X$O8@O
þÿv:wx†‡
!
:zîÀÜÎ\•
$
оEî =
$
†}ît
5$
S⻕¥Ý
$
^e2
& s 4$$ t.
MS
$ .P0
îо‰#­ãI
*
±g
þÿofÁZî
$
,cRvð
N.O
n
;S€Í
Rf
*
ãîïMS
$>@9:3#&$
±DÖòµ
)

$
s³þÿãÕþ
) t$
5
Q
=.O$

($
)
O
Ÿå×
(#
½©
$
ѹj!
âî,
$
g¿¨©ª«¬­À
$
$e$4$e$5$e$%$e$($e
%ãw_øÄÀ
!

ãÕ
$L& N.O
n
$

4
Qͽ
$
\evӊ[6
)$$
)
O*
±D
& D
î
9G8
ÈüD#þÿ[Ž
$
u
ÌÖ#
&($ 0.
ìÐÕ
!=
&($
$
þÿ[Ž
v=
î,À
=
=
¹jÀ
t$$e*
X_O
v:Z É„•d†‡
!
оîïw
$
ef
‰ò•dÀs
$
ø¹þ
f ..
4
$$$ .`.O
n
:
k¬iu
!
ì×
F9?9
±DÖ
4% s
ž_
# D
ît
⻕¥Ý
$
ñ2
5$$ T..P0
n
MS
$ .P0*
F9?9
±DÖ
!
Ð
$e IB8
#­ãIî
$
Ÿå×±

$
BþÿÇÒêþÿXY_
!

3S,QP0
àH
6Ʉ•dþÿ
*
þÿÖ5¿ðî
$L)5e
…už
_
$
s†ãÕþ
t$
5
Q
=.O$

$$
)
O
Ÿå×
(#
½©
$
±D
)& D
îî,
*
Ğܹj$
g¿¨
©ª«¬­À
$$e$4$e$5$e$%$e$($e
%ãw
_øÄÀ
!
(›ãÕ
$L& N.O
n
$

4
Qͽ
*
±D
& D
î
9G8
ÈüD#þÿ[Ž
$
uÌÖ#
=
&($
$
Z I
v! n=
î,À
==
¹jÀ
t$$e*
XO
äù´,
!
=YI
9u+
†¤
$
–œ
4
ž,ä
ù=YÐ_}ÝÁ
*
YO
÷A
YX!O
Z É„Èÿ•–—†‡
!
–œêÕ%ã,
†‡¨©ª«¬­„—,‹…ÄmÖþ
*
†‡†
|
$
¨©ª«¬­ß}ÝFZ :zMvɄÈÿ
•–—
$
%ã:,i
%
~ªSêO,ùi¹i ü,
.))&).
Ìí·R
#
Üɤh
3
[Á¥¦÷ø§!¨©ª«¬­®¯€Ü[Á°±Õ†‡
‹|}…¢o›œ
*
%㬭$
$e k5$e
:,
i¹„—,‹PB|}…ÅÆ
+

%$e
Ir:
,iO
$
„—,‹|}Ñ
$
Tüѧ¨‹o
$
´
p
2+
%㬭$
$e k5$e
~ªS¹„—,
‹PB|}…ÅÆ
+

%$e
Ir~ªSO
$
„
—,‹|}Ñ
$
Tüѧ¨‹o
$
´p
B+
%ã¬
­$
$e k%$e
O,ùi¹„—,‹PB|}
…ÅÆ
+

($e
IrO,ùiO
$
„—,‹|
}Ñ
$
Tüѧ¨‹o
$
´p
<*
J[´?
$

ž©€Ü¹„—›œPB}݅ÅÆ
$
ÈG5†
‡D¤rù
4
å€Üü˜k¨©ª«¬­Z É„
Èÿ•–—$lŒ#¯›œ
*
‹kÀ*+

!f$L$5$
)
!f$L$+
¨©ª«À*+
4
!f$L$5$
&
!f$L$*
p
!
:,i
!2%
~ªS
!B
êO,ù
!<
i…„—›œ
!

9u+$v$
IPNL!:0DP]PQP-0 C[C,QJ-[KSC-0P[R-TP0!2$ KSC-0-R!B$ S0U S.6NUSRP0!< -0 WQCTP0C,-0QTS,QP-0!

9u+$v$
YXO

G;I3
’b†‡
!
–œêÕ%ã,†‡
¨©ª«¬­Z 
G;I3
’b…ÄmÖþ
*
†‡
†|
$
¨©ª«¬­ß}ÝFZ 
>2Y)#&L%
þÿ
’b
G;I3
ÈÉ
$
%ãP…ɳ
%
¨ª
%
ÅP…É
âÎϦꪫ馹 üZ 
G;I3
,‹B}
݅¢o›œ
*
%㬭$
$e k4$e
P…ɳ
¹ üZ 
G;I3
’b,‹PB|}…ÅÆ
+

5$e
IrP…ɳO
$
i ü]*
$

G;I3

’b,‹|}Ñ
$
Tüѧ¨‹o
$
´p
)2*
%
㬭$
$e k5$e
¨ª¹ üZ 
G;I3
’
b,‹PB|}…ÅÆ
+

%$e
Ir¨ªO
$
i ü]*
$

G;I3
’b,‹|}Ñ
$
T
üѧ¨‹o
$
´p
)B*
%㬭$
$e k5$e
Å
P…ÉâÎϦ¹ üZ 
G;I3
’b,‹PB
|}…ÅÆ
+

%$e
IrÅP…ÉâÎϦO
$
i ü]*
$

G;I3
’b,‹|}Ñ
$
T
üѧ¨‹o
$
´p
)<*
%㬭$
$ k4$e
ª«
馹 üZ 
G;I3
’b,‹PB|}…ÅÆ
+

5$e
Irª«é¦O
$
i ü]*
$

G;I3
’b,‹|}Ñ
$
Tüѧ¨‹o
$
´p
)F*
J[´?
$
%㞩€Ü¹Z 
G;I3
’b›
œPB}݅ÅÆ
$
ÈG5†‡D¤rù
&
å€Ü
k¨©ª«¬­Z 
G;I3
’b$lŒ#¯›œ
*
YXYO
~
8@O
þÿwx†‡
!
–œêÕ%ã,†‡
¨©ª«¬­~¡
8@O
þÿwx…,‹ÄmÖþ
*
†‡†|
$
¨©ª«¬­ß}ÝF~¡
8@O
þÿw
x
$
%ãP…ɳ
%
:,i
%
¨ª
%
¨ª—
%
ª«é
¦©ä~
8@O
wx›œBâãhՅÑ
*

¬­$
$e
P…ɳ¹ ü~
8@O
þÿwx,‹
PB|}…ÅÆ
+

4$e
IrP…ɳO
$
i
 ü]*
$
~
8@O
þÿwx|}Ñ
$
Tüѧ¨
‹o
$
´p
42*
i ü]*
$
~
8@O
þÿwx,
‹O:,i`|}Ñ
$
Tüѧ¨‹o
$
´p
4B*
Þ^F
$
%㨪HB]ㅁÑ×U
$
´p
4<*
%㬭$
$e k4$e
¨ª—¹ ü~
8@O
þÿwx,‹PB|}…ÅÆ
+

5$e
Ir
P…ɳO
$
i ü]*
$
~
8@O
þÿwx,‹
|}Ñ
$
Tüѧ¨‹o
$
´p
4F*
%㬭$
$e k4$e
ª«é¦¹ ü~
8@O
þÿwx,‹P
B|}…ÅÆ
+

5$e
Irª«é¦O
$
i 
ü]*
$
~
8@O
þÿwx,‹|}Ñ
$
Tüѧ
¨‹o
$
´p
4?*
J[´?
$
%㞩€Ü¹~¡
8@O
þÿwx,‹PB|}…ÅÆ
$
ÈG5†‡D
¤rù
5
å€Ük¨©ª«¬­~¡
8@O
þÿwx
$B#¯›œ
*
YX%O
Z É„•dþÿwx
!
–œêÕ%ã,†
‡¨©ª«¬­Z É„•dþÿwx…,‹Äm
Öþ
*
†‡†|
$
¨©ª«¬­ß}ÝFZ É„
.4)&).
)$5
x
#
y ÿ
&$
!ÿ
)
|
X-RL&$$ ;-+) VW0C$ )$5
!!
¹jÀ*+

!f$L$5$
)
!f$L$+
‹kÀ*+
4
!f$L$5$
&
!f$L$+
¨©ª«À*+
5
!f$L$5$
#
!f$L$*
p
)!
P…ɳ
!2%
¨ª
!B%
ÅP…ÉâÎϦ
!<
ꪫé¦
!F
¹
G;I3
Üq…Z ›œ
!

9u+$v5
IPNL)!:0DP]PQP-0 -[NSRP,S,PU!2$ ,P00S.SRUCD6UC!B$ KC0QSNSR-6RNRW,-JC!<$ S0U KS,D6.S0!F -0 G;I3

JC,TCQP-0!

9u+$
v5
¹jÀ*+

!f$L$5$
)
!f$L$+
¨©ª«À*+
4
!f$L$5$
&
!f$L$*
p
4!
P…ɳ
!2%
:,i
!B%
¨ª
!<%
¨ª—
!F
ꪫé¦
!?
¹
8@O
þÿwx…ÅÆ
!

9u+$v4
IPNL4!@T-.-QP-0 -[NSRP,S,PU!2$ KSC-0P[R-TP0!B$ ,P00S.SRUCD6UC!<$ cWCT,CQP0!F$ S0U KS,D6.S0!? -0 8@O,CRJKT-RP[CT3
SQP-0!

9u+$v4
•dþÿwx
$
%ã:,i
%
~ªS
%
ÅP…ÉâÎ
Ϧê:i©äZ É„•dþÿwx›œâã
hÕFw¢
*
%㬭$
$e k5$e
:,i¹ 
üZ É„•dþÿwxPB|}…ÅÆ
+

%$e
Ir:,i
$
 üZ É„•dþÿ,‹|}
Ñ
$
´p
&2*
%㬭$
$e k%$e
~ªS¹
 üZ É„•dþÿwxPB|}…ÅÆ
+

($e
Ir~ªS
$
 üZ É„•dþÿ,‹|}
Ñ
$
B[Hüѧ¨‹o
$
´p
&B*
%㬭
$
$e k5$e
ÅP…ÉâÎϦ¹ üZ É„
.&)&).
Ìí·R
#
Üɤh
3
[Á¥¦÷ø§!¨©ª«¬­®¯€Ü[Á°±Õ†‡
•dþÿwxPB|}…ÅÆ
+

%$e
IrÅ
P…ÉâÎϦ
$
 üZ É„•dþÿ,‹|
}Ñ
$
–T[Hüѧ¨‹o
$
´p
&<*

¬­$
$e k4$e
:i¹ üZ É„•d
þÿwx,‹PB|}…ÅÆ
+

5$e
Ir
:i
$
 üZ É„•dþÿ,‹|}Ñ
$
´
p
&F*
J[´?
$
%㞩€Ü¹Z É„•
dþÿwxPB|}…ÅÆ
$
ÈG5†‡D¤r
ù
&
å€Ük¨©ª«¬­Z É„•dþÿ
wx$B#¯›œ
*
¨©ª«À*+

!f$L$5$
)
!f$L$*
p
&!
:,i
!2%
~ªS
!B%
ÅP…ÉâÎϦ
!<
ê:i
!F
¹É„•dþÿwx…Z 
!

9u+$v4
IPNL&!:0DP]PQP-0 -[KSC-0P[R-TP0!2$ KSC-0-R!B$ KC0QSNSR-6RNRW,-JC!<$ S0U SR]P[R-TP0!F -0 D6JQCT-.6-.S,CRJKT-RP[CTSQP-0
!

9u+$v4
%O
ýx
Üɤh()
!9:@
$[åB Õ¦qÁ…
ÜM F()
,-
$
B®‹vHÁ
! KTCUCQCT.P0S3
QP-0%
À_¡áÁ
!JKC,P[P,TC,-N0PQP-0
…À
$
²&
²éXœ×$,[Á€ÜÜM†‡
,(3$-
$
5†‡
Ö×Üɤh…´,HÑÂã ü$S̀Ü
$
œ
×,‹ÄmÖþ†‡
$
5†‡Kœ
9:@
´,ŠQ9
$, ü$Âã_øÄ
$
“¡m[ÁĞ#âã
ãՅ[Á€Ü¹ ü³v…Ċ˜…ÅÆ
*
V
@üIk™žiB$,…|Ò
!
1$,Í-v”w
…ž©€ÜâXZí

w§!V/[ÁÜɹ ü
Ċ˜…ÅÆ
*
Våh
9:@3
[Á¥¦÷ø§!
…´,
$
6Öהä‰È4ß$,…[Á,‹Ä
mÖþD9L[åRDN
*
ɄtՖ—$ilÁîB…®¯·lÈ
—
,(-
$
¨©ª«¬­@tZ É„–—JÙilÁ
îB
,&-
*
5†‡–œÜɤh()%ã:,i
%
~
ªSêO,ùi
$
 üZ :zMvɄ–—,‹
|}Ñ
$
Tüѧ¨‹o
$
†|rù
4
QۆB
„—›œ
* R†‡†|
$
:,i@tZ 
Ʉ–—JÙîB
,)$-
+MSTSUS
Rl*~ªS˜ÂZ
 Èÿ•–—
,)-
+
ɱR@tÝGv#†|O,ù
i$ÊgTĊ…®¯[Á€Ü
,))-
+
rù†‡hÒ
L5†‡…÷x
*
J[´?
$
êÕ%㞩_øÄ
b©ä ü„—,‹|}Ñ
$
|˜P…ɳü
˜HBZ MvɄ–—›œ
,)4-
*
3r
$
7ŽI
6:,i
%
~ªSêO,ùi$¨©ª«ª«¬­
JÙilÁîB…®¯[Á€Ü
*
#žÈÉ
G;I3
‰È$†Ï¶#ž|…#
¯ô̑[
,)&-
$
¨©ª«¬­@tZ 
G;I3
’b
JÙ¶#ž|
,5-
*
5†‡ˆœÜɤh()%
ãP…ɳ
%
¨ª
%
ÅP…ÉâÎϦꪫé
.5)&).
)$5
x
#
y ÿ
&$
!ÿ
)
|
X-RL&$$ ;-+) VW0C$ )$5
¦
$
 üZ 
G;I3
’b,‹üѧ¨ÁF}Ýh

$
†|rù
&
Q€ÜBZ 
G;I3
Üq›œ
*
†‡†|
$
P…ɳ
,)5-
%
¨ª
,)#-
êÅP…ÉâÎ
Ϧ
,)%-
¹
O@8
·©…
>2Y)#&L%
þÿ
G;I3
’b
ÄB}݅Z ›œ
*
ãO
$
ª«é¦$…¼SÖ
ª«é¦BÞ^…Z ›œ
,)-
*
J[´?
$
†‡
†|
$
¨ª—¹
O@8
·©…
>2Y)#&L%
þÿ
G;I3

’bB|}…Z ›œ
,)(-
+
jF
$
êÕ%㞩
_øÄb|}Ñ üZ 
G;I3
’b…,‹
*
3r
$
7ŽI6P…ɳ
%
¨ª
%
ÅP…ÉâÎÏ
¦êª«é¦$¨©ª«ª«¬­@tZ #žÈ
ÉÜqZ ¶#…®¯[Á€Ü
*
_-0N
R–œ
8@O
þÿv:wY‹k§3LÃ
ąXYw·›œ
,4$-
$
5^ˆœ1‹kÓI¨©ª
«¬­B~¡
8@O
þÿwx…,‹
$
¡[³†‡
†|êÕ%ãP…ɳ
%
:,i
%
¨ª
%
¨ª—ê
ª«é¦î
$
 ü~¡
8@O
þÿwx,‹üѧ¨
ÁF}Ýh
$
†|rù
5
Q€ÜBXYw·›
œ
*
†‡†|
$
:,i
,4-
%
¨ª
,4)-
ꨪ—
,44-
˜
Â|}~¡
8@O
þÿwx
+
ª«é¦HB}݅
XYw,›œ
,4&-
+
ãOÝG,eÜÝH†|P…
ɳFD XY[Á
,45-
*
G:
$
¨©ª«¬­…
ž©c„€ÜÄâF~¡
8@O
þÿwx…[Á
*
ÈG
$
7ŽI6P…ɳ
%
:,i
%
¨ª
%
¨ª—ê
ª«é¦$¨©ª«¬­@tXYw·JÙ¶#
…®¯[Á€Ü
*
Ʉ•d$¨©ª«¬­…®¯Óož‘
[
,4-
$
ˆœÜɤh()%ã:,i
%
~ªS
%
ÅP
…ÉâÎϦê:iî
$
 üZ É„•dþÿ
wx…,‹|}Ñ
$
†|rù
&
Q€ÜBÉ
„•dþÿwx›œ
*
†‡†|
$
:,i
,4#-
%

S
,4%-
êÅP…ÉâÎϦ
,4-
¹éå9&Ðþÿ
Bwx›œ
+
F:iHBo1·¸›
œ
,4(-
*
G:
$
%㞩€Üb|}ÅÆ üÉ„
•dþÿwx,‹
$
ÈG
$
7ŽI6:,i
%
~ªS
%
ÅP…ÉâÎϦê:i$¨©ª«¬­Z É
„•dþÿwx…®¯[Á€Ü
*
5†‡–œÖ×Üɤh…€ÜêÕ%ã´
,
$
”äF|ÓL¨©ª«¬­É»ilÁîB
%
¶#êɄ•dÓož]“…®¯[Á€Ü
$
–
Y5†‡÷A
$
rù€ÜÜá`
5$e
IrO
$
ü
¹ ü[Ád[HÅÆ
$
D¤ üth$ï¹
]“€Ü¡m˜G…ÐÑøïêmÑn 
*
5†‡
6¨©ª«¬­…mnÌXáÌD9LЧY
*

|j?}
#
, -!
¹×¶
$
ÅÊ
$
!¸$
$
R
L
âãüѨ©ª«¬­É»i
lÁîB»‹ÂƇ
,V-L
$%$,-.
$ )$4$ 4!)#
)$(L
, ) -!
Ø[š
L
¨©ª«¬­É»cÁ¶#
$$
ºÜÝ
,V-L
$
%l,-.
$ )$$%$ #!# $)L
, 4 -!
çf¿
L
¨©ª«¬­É»
#$
ºÉ„•d½¾»‹ÙÚ
,V-L
ÎA
$ )$$$ 4!# )&5L
, & -!
!¸$
$
ÜvO
$

$
R
L
¨©ª«¬­Z :zMvÉ
„–—‹ožÄmÖþ§!
,V-L
$q,
$ )$$($ &$!&#
#$(L
, 5 -!
Þï
$
΃
$
Ãm$
$
R
L
¨©ª«¬­¹æzcÁ¶#
…ÅÆ
,V-L
$,,e½¾
$ )$4$ )(!&# )L
, # -!
÷í€
$
÷‹‹
$
`µ‹
$
R
L
¨©ª«¬­¹É„8~_
>žæz =
m
G
Z[þÿ=ê
;b
þÿ¸[Á…Å
Æ
,V-L
$%Ğ´ü-.
$ )$$ %!(# &5L
, % -!
´!h
$
ú†
$
<
$
R
L
¨©ª«¬­DEąv:
Çd[ÁŸ 
,V-L
$%,-.
$ )$)$ &%!$# 4L
, -!
oèÎ
$
 EÆ
$
QØÍ
L
[åB Õ¦qÁ…()
///
Üɤh
,V-L
ÜÝ_
$ )$$$ )(!# ((L
, ( -!HW V$_DS0NM$ZWS0 H$CQSRL8WT[S,C3P0PQPSQCU .-RC,WRSTR6P.3
KTP0QCU K-R6.CTP,,-RW.0# P0 JPQW J60QDCJPJS0U SKKRP,SQP-0 [-T
JC.P3KTCKSTSQPdCJCKSTSQP-0 ]6DPND KCT[-T.S0,CRPcWPU ,DT-.S3
Q-NTSKD6,V-LV,$-!YS0N^ $ QCU K-R6.CTJdPSTP0N3-KC0P0N.CQSQDCJPJK-R6.CTP\SQP-0 [-TJ-RPU3
KDSJCC7QTS,QP-0 -[]PJKDC0-R2,V-L20SRBP-S0SR&$!&# &)4L
,-!ICTW\\P9H$O-]-Vb$VS0RC?9$CQSRLBP-SdSPRS]PRPQ6-[NSR3
RP,S,PU S0U ,SQC,DP0J[T-.NTSKCJCCU K-R6KDC0-RC7QTS,QPJP.3
KT-dCU ]6TCKCSQCU U-JP0NP0 TSQJ# P.KRP,SQP-0J[-TQTCSQ.C0QP0
2R\DCP.CTJUPJCSJC,V-LV2R\DCP.CTJFPJ$ )$$($ !# 4L
,)-!
å™%
$
Þ؀
$
¿7ˆ
$
R
L
¨©ª«¬­®¯‹o€Ü
k*GÇv8…,PïŽ
,V-L
$%$,-.
$ )$$4#
!# $5L
,4-!MSTSUS9$ MPTS6S.SZ$ ZS.S\SEP>L@DST.S,-R-NP,SRJQWUPCJ
-0 0S.SRUCD6UCP0 U-NJ,V-LV@DST.S,-]P-U60$ ()$ 5 ! #
54(L
,&-!HS-^ $ ZW _$ _DS-Z$ CQSRLFCdCR-K.C0Q-[S0 O<.CQD-U [-T
JP.WRQS0C-WJS0SR6JPJ-[,P00S.P,S,PU S0U KSC-0-RP0 TSQKRSJ.S$
S0U PQJSKKRP,SQP-0 Q-SKDST.S,-EP0CQP,JQWU6S[QCTP0QTSNSJQTP,
SU.P0PJQTSQP-0 -[HWP\DP3IWRP0N,SKJWRC,V-L)$$($ %$!4=&# 5(%L
,5-!-[Q6KP,SR,-0JQPQWC0QJP0 *DPQCKC-06T--QS0U JWR[WT[W.PNSQCU
*DPQCKC-06T--QS[QCT-TSRSU.P0PJQTSQP-0 Q-.P,C,V-LV?QD0-3
.#)&).
Ìí·R
#
Üɤh
3
[Á¥¦÷ø§!¨©ª«¬­®¯€Ü[Á°±Õ†‡
KDST.S,-R$ )$$$ )(!)# #%L
,#-!HC0[SO$ VPS0N_$ M-0N_$ CQSRLGDCJ,TCC0P0NS0U PJ-RSQP-0 -[
S0 C[C,QPdCS0QP3C0U-Q-7P0 .-0-.CT[T-.>SUP7@SC-0PSC>W]TS
WJP0NS[P0PQ6]P-JC0J-TQC,D0-R-N6,V-L:0Q:..W0-KDST.S,-R$
)$$5$ 5!## $$%L
,%-!2]TSDS.b$ @[PJQCT9$Y-DTRP0 I$CQSRL>CRSQPdC]P-SdSPRS]PRPQ6
-[,-W.STP0 [T-.,P00S.-0 S0U ,P00S.-03,-0QSP0P0N[--UJ,-.3
KSTCU Q-PJ-RSQCU ,-W.STP0# S[-WT3*S6,T-JJ-dCTJQWU6P0 DW.S0
d-RW0QCCTJ,V-L9-R;WQTI--U >CJ$ )$$ 55!&# #&&L
,-!OP0NZ$S,QCTP\SQP-0 -[QDC.S/-T]P-S,QPdC,-.K-0C0QJ-[!&#$( %&%&+S0U
QDCPT.CQS]-RPQCJP0 TSQJ]6O<3?8:398!,V-LBP-.CU Q-NT$ )$)$ )#!(# $(L
,(-!
»€ 
L
$AÉ»ilÁîB†‡¡¢
,V-L
)/$A,æ
j
$ )$5$ %!# )))L
,)$-!KRC.C0QJP3*W3QS0NS0U DCSRQD3TCRSQCU cWSRPQ6-[RP[CP0 K-JQKSTQW.
*-.C0# SK-KWRSQP-03]SJCU ,-TCRSQP-0SRJQWU6,V-L?dPU BSJCU
<-.KRC.C0Q2RQCT0SQ9CU$ )$4$ )$4# %($&%&L
,)-!MSTSUS9$ ZS.SJDPQS2$ 2]WTSUS9L@DST.S,-R-NP,SRJQWUPCJ
-0 QDCT--Q]STE -[!(&$( 1&*4(L:L20QP3P0[RS..SQ-T6C[C,Q$
KTCdC0QPdCC[C,Q-0 JQTCJJ3P0UW,CU NSJQTP,CT-JP-0$ P0DP]PQ-T6
C[C,Q-0 NSJQTP,/WP,CJC,TCQP-0 S0U -QDCTC[C,QJ-[KSC-0-R,V-L
ZSEWNSEW _SJJDP$ (%)$ ()!## %5$L
,))-!
ɱ
$
¨¡-
$
•
$
R
L
œ×9&„”ÒilÁîB…T
Ċ޴®¯[Á€ÜÝG,eÜÝ
,V-L
$%$,-
.
$ )$&$ 4(!# 4L
,)4-!
ÉíÛ
$
ç×È
$

$
R
L
_¤TĊZ :zMvÉ
„–—‹o§![Á1>…€ÜÜÝ
,V-L
$%$,-
.
$ )$$$ 45!)&# 44#)L
,)&-!

$
ç7f
$
p7Í
$
R
L
#
G;I%J:O3)>%:O3)
¹{Á
¶#…,(!Y
,V-L
b1XY-.
$ )$$$$ 4 !&#
)&#L
,)5-!OCCVY$ BSCS,PU P0DP]PQJRPK-K-R6JS,,DSTPUC!O@83P0UW,CU P0[RS..SQP-0 ]6
;T[) S,QPdSQP-0 $ 7$4#&S0U P.KT-dCJJWTdPdSR-[.P,CP0 O@83P03
UW,CU C0U-Q-7C.PS.-UCR$ 7$7&,V-L9-R4($!=)# &4L
,)#-!@S00CC<$ -[CJJC0QPSR-PR[T-.QDCRCSdCJ-[,$(1&1*1%(+$( S0U ,P00S3
.SRUCD6UC-0 RPK-K-R6JS,,DSTPUC3JQP.WRSQCU V%%&2L ,CRJ,V-LV
2Ud@DST.GC,D0-R>CJ$ )$&$ 5!&# #&L
,)%-!ICRU.S0 b8$ 8SDSJTS]WUDCb$ OS*R-T9F$ CQSRLR 7$4#&S0U
$ 7$7&P0DP]PQP-0 -[O@83JQP.WRSQCU QW.-T0C,T-JPJ[S,Q-T3SRKDS
JC,TCQP-0 ]6QDCNSR-QS00P0
#
9CU ,)-!
úíù
L
¼SÖª«é¦¹:zXYŠ˜…ÅÆ
,V-L
…œ
¾
$ )$$)$ )&!&# 4(L
,)(-!MSTSJJQS0PA2$ 9-P0 8$ GDS.QP-0J,SWJCJ60CTNPJQP,P0DP]PQP-0 -[KT-P0[RS..SQ-T6.CUPSQ-TJC3
,TCQP-0 [T-.RPK-K-R6JS,,DSTPUC3P0UW,CU >2Y )#&L% ,CRJ,V-L
:0[RS..>CJ$ )$$$ 5(!(# %L
,4$-!_-0NZ$ YS0NZ$ OPM$ CQSRL8P.WRQS0C-WJcWS0QP[P,SQP-0 S0U
JKRC0-,6QC3KT-RP[CTSQP0NS,QPdPQPCJ-[0W,RC-JPUCJS0U ]SJCJP0,#7$
%&#* @S0Q-QTP,DW.,V-L@DST.S,-N0 9SN$ )$&$ $!&$# 4(L
,4-!-[J60-dP-,6QCJKTCQTCSQCU ]6T:O3SRKDSS0U TCNWRSQCJ?@& TC,CK3
Q-TC7KTCJJP-0,V-LV?QD0-KDST.S,-R$ )$$ 4%!4# )%5L
,4)-!9--0 ?Z$ OCC9>$ YS0N2H$ CQSRLFCRS6CU -,,WTC0,C-[
M3TSJ)X3P0UW,CU DCKSQ-,CRWRST,ST,P0-.S*PQD R-0N3QCT.QTCSQ3
.C0Q*PQD ,P00S.SRUCD6UCJ,V-L?WTV@DST.S,-R$ )$$#$ 54$
!4# )%$L
,44-!VW0NVM$ bS0NV:$ bP.M8L?[C,Q-[cWCT,CQP0 -0 P.KSPTCU
P..W0C[W0,QP-0 P0 .P,CC7K-JCU Q-PTSUPSQP-0 ,V-L;WQT>CJ
@TS,Q$ )$)$ #!&# 4$L
,4&-!MS0 8 8$.-UWRSQP0NC[C,Q-[*SQCTC7QTS,QJ[T-.dSTP-WJ.WJDT--.J,V-LV
2,WKW0,Q9CTPUPS0 8QWU$ )$$($ )!4# )L
,45-!ZSUSdFb$ bDS0 I$ ;CNP28L@DST.S,-KD-TC.-UCRP0N$ .-3
RC,WRSTU-,EP0N$ a82>$ S0U P0 JPRP,-2F9?GJQWUPCJ-[NSRP,
S,PU UCTPdSQPdCJ[-TP..W0-.-UWRSQ-T6S,QPdPQ6,V-LV9-R9-UCR$
)$)$ !## )54L
,4#-!_DS0NO$_DS0N8L9-UWRSQP0NB,R3) [S.PR6KT-QCP0JS0U ,SJKSJC34
P0 P0UW,QP-0 -[SK-KQ-JPJ]6KSC-0P[R-TP0 P0 DW.S0 ,CTdP,SR,S0,CT
,CRJ,V-L@D6Q-QDCT>CJ$ )$$ )5!$# 55L
,4%-!ZP0 V$ YW ;$ _C0NI$ CQSRL@SC-0-RP0UW,CJSK-KQ-JPJP0 DW3
.S0 -dSTPS0 ,S0,CT,CRJ,V-L2,QSMPJQ-,DC.$ )$4$ 5!#
45L
,4-!MWSbG$ YS6GF$ OP0 VbL@C0QSNSR-6RNRW,-JCP0DP]PQJCJQT-3
NC0 TC,CKQ-TSRKDS]6R6J-J-.C3UCKC0UC0QUCKRCQP-0 S0U .-UW3
RSQCJ?T]B=@:4b=2EQKSQD*S6P0 DW.S0 ]TCSJQ,S0,CT9,CRJ,V-L9-R,4(-! W^ Y$ _D-W O$ 9S^ $ CQSRLGDCTSKCWQP,C[C,QJ-[,-.]P0SQP-0
-[KSC-0P[R-TP0 S0U SR]P[R-TP0 [T-.@SC-0PS>SUP7-0 TSUPSQP-0 S0U
,DC.-QDCTSK63P0UW,CU .6CR-JWKKTCJJP-0 P0 .P,CS0U TS]]PQJ,V-L
2JPS0 @S,V
~-0
!
ˆ‰Š
#
.%)&).