免费文献传递   相关文献

Effect of Gualou Xiebai Banxia decoction combined with Xuefu Zhuyu decoction on myocardial apoptosis and relevant protein expressions in miniature swine phlegm and blood stasis type coronary heart disease model

瓜蒌薤白半夏汤合血府逐瘀汤组方对小型猪痰瘀互结证冠心病模型心肌细胞凋亡及相关蛋白表达的影响



全 文 :)$5
x
#
y ç
&$
èç

|
?-Ec&$$ ;-+ SD0A$ )$5
PQRŒýST¶UVWXTƒñY:ûZ[X
\]^_S`ßûSabcde”
¤¥‹Œ•–­fg
Tâã
!)
!
0jk

!
!
Eä§

!
å¯A

!
Eæç

c
”ã”]°„^ \Ó]^ mÔ]„xyÕ
!
”__½no¯ghijk
!
no
$$$(%
)c
noSTUV6jÕ 6j]„xz”b
!
no
$))$##

tu
#!
WÈñ,PQRŒýST¶UVWXTƒñå_S`Sa€U‚$YKAde­„…ŒÀ
$
딵@ÝPQR
ŒýST¶UVWXTƒñY:ûZ[X\]^_S`ßû†mÛ¡
$
µ·åƒñY6ßûSabcde”¤¥‹Œ
P,E3)$
PW7$•–­fg
)
*~$%”µ:ûZ
5
ë
$
Ñ@—½Y5ƒ
&
ßûƒÂ[X+}ƒ
)
ßûƒÂ[X+
}ƒõd(rkzb
)
ϖ
$
~9Ùòm_wá!A‚
$
Ȗhpz,+Oé6´d(rkzb

Ï
)
Y5ƒõl@rkz
b
$
Ï
$
ñZ_wá!A‚
)
”µ]:–мá€
$
Í»¼ÌŠÐSa
$

$
W*AçP¿~€
$
*~
IF;TH
()‚®Sa
de
$
¸cƒê_
!B..D0-VBQU-,VA.B,WE$:]<
()‚®Saƒê­
P,E3)$PW7$3
)
]•Ýà
IF;TH
ò‚®­Y5ƒ
&
ßûƒ”[X+}ƒ­deO=
!WL-LU-QBQB0KA7$2:
—Ïl
$c()k$)%c#k$%c)k$
[X+}ƒ­bc
deO=ñÝ:Ößûƒ­deO=
!Dq$c$)
[X+}ƒ¢ßûƒÆÇ
$P,E3)
‹Œ•–ÝÞN
!Dq$c$$PW7
‹Œ
•–ÝÞ`‹
!Dq$c$*
[X+}ƒ
•–ŒÝދÖßûƒ
!Dq$c$)
õÉ]••ñPQRŒýS
T¶UVWXTƒñY:ûZ[X\]_S`ßûSadebcBñÝ­JæÅ~
)

vwx
#!
_S`[X\]^
*
PQRŒýST¶UVWXT
*
Sabcde
*IF;TH*P,E3)*PW7*
yz)(
#!)$&33)%

{|}T
#!
ãf
(
gŠº_©Ã
)
°tgŠ‹~
)$)ab$(4$$$)3$$&#%
no¯;W;_~
a4$$$$)54$$##

~Ar
#!
!
0jk
!IAE$$$##)%&$&(!T3.WBE$EBD/7$4)&1QB0Wc,-.

Arˆ‰
#!
Tâã
!
æ¦xyÿ
!IAE$$$#$%)$#)5!T3.WBE$6W0WBZD-$#1#4c,-.
)76G017F=,.1=_-6;,-L,3D-, /6G1G0-13G1+;-36/Q-05_=67=P5=?=/6G1G0-13
13+?1G,2/-,.,:1:019-9,3/26.6I,30:2106-36D:2699-139-3+-3-,0=269Q-36
:5.6N+,3/;.11/90,9-90?:6G1213,2? 56,20/-96,96+1/6.
Y2;2B3ZD-
$)
$ H:FSBW037D0

!
$ H:bB03\VB

$ R_;NbBW-37BW

$ H:]-0Z3^D0

!cR31/6$)+=#1/7:$./7#4!7/$37$1$ S/&6#3 0)1H/#4$ 89/3# ;7#.$<&)+89/3$1$:$./7#4!7/$37$1$
=$/>/3? %$&#()*#)*&)+D9#*<#7)4)?&)+B*#.//)3#489/3$1$:$.7/3$$ =$/>/3? $$$($ 89/3#*
)c=$/>/3? #PI$0$#49 #()*#)*&8$3$*+)*84/3/7#4#()*#)*&,$A$4)H<$3$ =$/>/3? $))$#$ 89/3#
+A;902,G0,!IVAXAVWeACAA0 eAX6[A*QUDKBAQ-0 UVAA[A,U-[NDWE-D bBACWBPW07BWKA,-,UB-0 ,-.CB0AK *BUV bDA[D aVD6D KA,-,UB-0
B0 B0VBCBUB0ZWL-LU-QBQB0 .6-,WXKBWEBQ,VA.BWEB0/DX6,WDQAK C6,-X-0WX6VAWXUKBQAWQAc:0 UVBQA7LAXB.A0U$ NDWE-D bBACWBPW07BWKA3
,-,UB-0 ,-.CB0AK *BUV bDA[D aVD6D KA,-,UB-0 *AXADQAK U-B0UAXeA0AUVA.B0BWUDXAQ*B0ALVEAZ.W0K CE--K QUWQBQU6LA,-X-0WX6VAWXU
KBQAWQA.-KAE$ B0 -XKAXU--CQAXeAUVAA[A,U-[UVA,-.CB0AK LXAQ,XBLUB-0 -0 UVA.6-,WXKBWEWL-LU-QBQW0K UVAA7LXAQQB-0Q-[P,E3)$
PW7$ -&%)-
À/%1
#
PQRŒýST¶UVWXTƒñY:ûZ[X\]^_S`ßûSabcde”¤¥‹Œ•–­fg
,-0UX-EZX-DL$ UVA.-KAEZX-DL W0K UVALVEAZ.W0K QUWQBQ3UXAWUB0ZZX-DLcIVA.-KAEZX-DL W0K UVAQUWQBQ3UXAWUB0ZZX-DL *AXA[AK *BUV
VBZV [WUKBAUQ[-XU*-*AA^Q$B0UAXeA0AK *BUV UVA,-X-0WX6WXUAX6B0/DX6W0K UVA0 ZBeA0 KXDZQW0K VBZV [WUKBAUQ[-XABZVU*AA^QcIVA,-03
UX-EZX-DL *WQ[AK *BUV -XKB0WX6KBAUQ[-X$ *AA^Q$ *BUV-DUUVA,-X-0WX6WXUAX6B0/DX6c2[UAXUVAA7LAXB.A0U$ .6-,WXKBWWUUVA/D0,UDXA
-[B0[XW,UAK WXAWQ*AXA,-EA,UAK W0K .WKAB0U-[-X.WEB03[B7AK LWXW[B0 QA,UB-0QcIVAIRI3.AKBWUAKFIG0B,^ A0K EWCAEB0Z!IF;TH
WQQW6*WQDQAK U-KAUA,UUVA.6-,WXKBWEWL-LU-QBQcIVAB..D0-VBQU-,VA.BQUX6!:]< UA,V0B`DA*WQWLLEBAK U-KAUA,UP,E3)$ PW7$
.-KAEZX-DL W0K UVALVEAZ.W0K QUWQBQ3UXAWUB0ZZX-DL *AXA$c()k$ )%c#k$ %c)k$ XAQLA,UBeAE6cIVA2:-[UVALVEAZ.W0K QUW3
QBQ3UXAWUB0ZZX-DL *WQQBZ0B[B,W0UE6E-*AXUVW0 UVWU-[UVA.-KAEZX-DL !Dq$c$c<-.LWXAK *BUV UVA.-KAEZX-DL$ UVALVEAZ.W0K
QUWQBQ3UXAWUB0ZZX-DL QV-*AK QBZ0B[B,W0UE6VBZVAXP,E3) LX-UAB0 A7LXAQQB-0 !Dq$c$ W0K E-*AXPW7$ A7LXAQQB-0Q!Dq$c$c:0 ,-0,EDQB-0$ NDWE-D bBACWBPW07BWKA,-,UB-0 ,-.CB0AK *BUV bDA[D aVD6D KA,-,UB-0 VWeAWQBZ0B[B,W0ULX-3
UA,UBeAA[A,UWZWB0QUUVA.6-,WXKBWEWL-LU-QBQB0 .B0BWUDXAQ*B0ALVEAZ.W0K CE--K QUWQBQU6LA,-X-0WX6VAWXUKBQAWQA.-KAE
+ 6^? Q12/9,!LVEAZ.W0K CE--K QUWQBQU6LA,-X-0WX6VAWXUKBQAWQA* NDWE-D bBACWBPW07BWKA,-,UB-0 ,-.CB0AK *BUV bDA[D aVD6D KA3
,-,UB-0* .6-,WXKBWEWL-LU-QBQ* IF;TH* P,E3)* PW7* /1-#!&d%(\EGeG++&!#!!&
!!
„…^”
$
Sa€UOóåSabcde
!WL-3
L-U-QBQ$
mŸlSabcdeISa€U‚­œ
Êš
$
‘åÛ¡SabcdeY€U‚$Sa
bc­JæZB¥­Å~
)
bcdeI[.bc
œá­¼eÝÞ
$
å&øÝÞ$ª“–[±²¤¥
Ž‘­•–
$
Ò$
C,E3)
Ž‘ùùI7˜ÇlDŸ¢
de}~¤¥­Ž‘
$
„…•ñ
$P,E3)
Â
PW7
—Ï
I
P,E3)
ùù$ZBP•¿­ÔdeÂËde‹
Œ
+,
)
Ç4hµ†_­ýthµ‹Œ
!,6QUAB06E
WQLWXUWUAQLA,B[B,LX-UAB0WQA$¦ílýtÇ

$
I¬¢ÂÁmde­¥‹Œ#[
$
Ide
­Ëá°
$
åbcdeÝÞ$ÐÖuS¾G
$
m¢d
e­Êˆ‡}~¤¥
+),
) ùù$§¥
MÅ~­IÉ{­
”ÒF{­¹ì—«
WÈñ,PQRŒýST¶UVWXT
ƒñå_S`Sa€U‚$YKAde­„…Œ
À
)
딵å$%:ûZ[X\]^_S`ßûŽ
É
$
~
IF;TH
8~ò®ðSabcdeO=
!WL3
-LU-QBQB0KA7$2:$
~¸cƒê_ñò‚®
C,E3)$
CW7
Ž‘‹Œ­•–Â
­•
–
$
Yåßû€USa­bcde†m„…
$
mµ·
WÈñ,PQRŒýST¶UVWXTYÒSab
cde­Û¡Å~
$
lÂÃì~$,ñ°}~j¿
Sa€U‚%SabcdeBrÌ=ÄW€?
)
!M
îk¢ñò
!T!M
ဗƒ”ÐÄ
!
$%”µ:ûZ
!A7LAXB.A0UWE.B0BWUDXAQ*B0A$ ë
$
Kñ
Â
$

!&c4 z&c4 ^Z$
k23&єµá€bO
$SÌ=
)
Ñ@—½Y5ƒ
&
ßûƒ
&
[X+}ƒ
$

5
ë
)
Y5ƒõl@rkzb
$
Ï
$

($$
Z-K
h
$
ñÅ_wá!A‚
)
ßûƒÂ[X+}ƒ
õ{ë
($$ Z-K
h
d(rkzb
)
ϖ
$
Å_wá
!A‚
$
Ȗé6õ{ë
($$ Z-K
h
d(rkzb
Â9”µ,€

Ï
)
!TM

!
PQRŒýST
.
ˆ·š
/$
kPQ
)& Z&

( Z&
ýS
) Z&
ŒÃƒ½
$
œ}mD@q
&
C[i]
$
k
)$k
ÈÉÌÍ
$
ÛÜA½
)
UVWX
T
.
AwHš
/$
kÙÚ
( Z&
’FÎ
( Z&
Ÿà
) Z&
·
Š
( Z&
QS
# Z&

# Z&
œs
5 Z&
+,
4 Z&
Ä»
5
Z&
«Å
( Z&
£»
4 Z
ƒ½
$
¾U_X
&
mD¢ä
$
3
ÌÛÜA½
)
õÉ
)
.,€k$%$A&®Kv
A®,„…N4|ñ¤Æ
&
WÈÛQAç
)

°ð?qsñ°z~ð
&
á€z•±=@pef
)
!T]M

!
wŸÆƉ
!
†%†ƒ—î
$
23_
6°DEÌ=
$
“<
$)$&$)*
:‰Eª™
!
ÉH
ç[’_,ÙBCDE
$
“<
$%$%$)*%#k
ÚñÕ
fyoEª™
!
ÉH¿5Hl,ÙBCDE
$
“<
$%$)
d(rk¤ñ¬®^ú
+4,
müõG&
$
{
$$ ^Z
l@rk$üÙ<|É
) ^Z&
<}
$c5 ^Z&
ZF
$ ^Z$
k23&&*ârkBCDEÌ=
$
I
$^<
83
)$$53$$$%) P,E3)!;3(#Q,3&()
Â
PW7!G3( #Q,35)#
åÚ
82;I2<>Fa
DE
*
IF;TH$G_R ^BU
åچ%(ÇÇÅBCDE
*
6°7åÚÇOÈû’€AÔ
BCDEÌ=
)
!T%M
ßû­st
!
ßûƒÂ[X+}ƒ
#
õd(r
-5%)-
)$5
x
#
y ç
&$
èç

|
?-Ec&$$ ;-+ SD0A$ )$5
kzb
)
Ï
$

($$ Z-K
h
$
ßàÖCñ#
$
ÝC
b£ ë
$
½á€È8¼Ú
$
DB½[
)
å[Éʂ
­ŽÉ
$
~9Ùòm_wá!A‚
#
“p!Eªw
ŸÆƉ#…–
$
—¿Íc±tá!
$
]ßÑSÕ
$

#O
á!Ë×
$
%á!Ë­c×EÙ:
)$$ F
-^Z
h
)
å
<
ûÌ
b
2@
!P?GDEQAXW
û

˜¦F
$
õ
#O45 H
Í_MšM×GÖÌ_wá!hƒmÌ
_wá!ºf
$
µ·Z_wá!­—×ùú
$
ºf–
GÙÌ­Mt
$
,MtGÙ_wá!˜`¢
!EA[UW03
UAXB-XKAQ,A0KB0ZCXW0,V$H2R
$1
$
{ëqMt†
Ù
H2R
$1
$
¦ùúö„
+$& p$
5
l)+5# p
$
5
GW$
L6
4$ Q$
Aá{ë
$
îÚ
4
¦
$
­D[ L
6{ë„â
+$4 p$
5
l+5)$ p$
5
GW
m¿ãA
á{ë
)
Í^Mt
&
{ë–
$
—¦ºfµ·
H2R
Ë
×ùú
$
Í^MšM×
$
]ß±tá!
$
‚ƒuc
$
n

5$
Ã
F
ô}
$
³sζ
$
nÄzbµ·
$
)
$56SUtæ
!IT<3%#)<
û
$
zë2UDE
)
é6´d(rkzb

Ï
$
[ÉÏX
$
„ÖS!
$
M
½ÄÐ
)
!T#M
)–~,
!
[X+}ƒ
#
PQRŒýST
4 Z
-^Z
h
¶UVWXT
& Z-^Z
h
$
_wá!A‚–ç
)
Ç
$
@ÝC€Âr9,
$
mé6´d(rkzb

Ï
$
{Ç)A{ëဆCð
($$ Z$
mBx£´×
z,
)
!T(M
Íî
!
”µ]:
!


Ï
$
,”µwƒ*
ÍÁ¿OUñòмá€
$
ÅÆÍQS§
$
õ’Ä}
3{£µ³U
$
å{ëË×1¾õF
$
mÖ_wÑ
Œ¡F,SN1—~½
5
€
$

$ck
¿ŽrL
Òê
!;3PI
)™$
$
W…žõ
5 .B0$
µ·{€S
a­»¼J
!;3PI
ÑÒõJ»Ó·õ

¢Ñ»¼J
!;3PI
žõJ»™êõ
$
ÅÆÍ»¼ÌŠJSa
$

$k
ƒ
!GP8$L]%c&

$
W*AçP¿

)
!T$MIF;TH
8~ò‚®Sabcde
!
45bc
de‚®,7¥ñqÂÅ
)
bcu$BÇõuäð
lq¿bc
)
2AFå{×ԀÉÑ@xŸ
5
ød
üA
! p&$$
¦è
$
{ø¦èã=
$$
øbc
$
Ȗ
ãpQ{¸øbc­debc=
$
deO=
!WL-L3
U-QBQB0KA7$2: j
debc=
=
tµ·bc=
p
$$k)
!T\MP,E3)$PW7$•–­‚®”
—˜
!
Sabc
P,E3)$PW7$¸
cƒ_žõ
$
4
8G
ò¸cƒ_6°7žõěÂ
Å
$GP8
P¬[ÔÅl¿Y5
)
{×ԀÑ@x
Í
5
øJ
$
ÕÖ5€
$
mƒ~`Äpߗ˜±Èã
pŒ2}rÂ?—2}r
)
!TM
Èãñò
!
PB=?Œ~ &
Ez1
•à
$
Ѓ
[ÆÇ*~n‘ñ{—˜
!_0A3*W62;_?2$
ô
ô[ÆÇì~
8UDKA0U3;A*3.W03MADEQW
ò†m
F
‚
µ
$
B¯—ÿ/k#[ÆÇ*~
>BKBU
—˜
)
õ
Dq
$c$5
•àZBÝÞ¿{_
$Dq$c$
•àZB†Ý
Þ¿{_
$
ì~
8G88 c5
Èã)ø*-Èã
)
M

T!M
Sadebc
IF;TH
òžõ
!
2AF
$

bl’de­Sabc
!
¿bc

už½êõ
$
u
¤YÇ4
$
ÊËÂ4:gW
$
ûdebc
!
q¿b
c

už½Ç×õ
$
bcu»ì¯­´Þw
$
ÊËñ

$
4:ñ[½
$
debcÐQü廼‰Ç­€
UJ
$
»¼JÂÑ Jde­bc¤YÇÀ
)
d
üA
! p&$$
Fã=
$
Y5ƒ¶$ïøÏq¿bc
$
2:
l
!$c() zc$4k$
ßûƒq¿bc—×ÇÐ
$
2:
l
!)%c# z5c55k$
¢Y5ƒ¤ÆÝÞNÐ
!Dq$c$*
[X+}ƒôÇßûƒÝގÀ
!Dq
$c$$2:
l
!%c) z)c5)k$
ïp
)
TM
Sabc8
P,E3)
Â
PW7
¸cƒê_žõ
!P,E3)
Â
PW7
q¿­bc—8$ïÇÎõuä—
×
$
q¿•–­bcœISabc
$
ïp
)
$
2$
P)
wƒSabc8
P,E3)
Â
PW7
¸cƒê_‚
®
$
ï•
)
ßûƒ¢Y5ƒÆÇ
P,E3)
•–F`
!Dq$c$$PW7
•–N
!Dq$c$*
[X+}ƒ
¢ßûƒÆÇ
$P,E3)
•–ÝÞN
!Dq$c$$PW7
•–ÝÞ`‹
!Dq$c$)
Ìà[X+}ƒ$LM
ÔdeŽ‘
C,E3)
­•–
$
KAËdeŽ‘
CW7
­•
–
)
ßûƒÔdeŽ‘‹Œ
P,E3)
¢ËdeŽ‘‹
Œ
PW7
ƈñ݋ÖY5ƒ
$
[X+}ƒ¢ßûƒ
ÆÇ
$
ÔdeŽ‘‹Œ
P,E3)
¢ËdeŽ‘‹Œ
PW7
ƈÝÞN4
!Dq$c$)
Ìà[X+}ƒqf
g–de¤¥Ž‘­•–
$
bcdeìKA
)
T]M
Sabc
¸cƒê_
žõ
!q¿bc—$$ïÇÎ
õu䌡—×
$
q¿•–­bcœISabc
$
ïp
)
$
<$ R)
wƒSabc8
¸cƒê_‚®
$
ï•
))
ßûƒ¢Y
5ƒÆÇ
•–ŒÝÞN
-#%)-
À/%1
#
PQRŒýST¶UVWXTƒñY:ûZ[X\]^_S`ßûSabcde”¤¥‹Œ•–­fg
!!!!!
Wc
Y5ƒ
*Cc
ßûƒ
*,c
[X+}ƒ
!
p
)
+
)
p
!
wƒSadebc
IF;TH
žõ
! p&$$
OBZc!IF;THQUWB0B0ZB0 .6-,WXKB-,6UAB0 ZX-DLQ! p&$$
p
)!
wƒSabc8
P,E3)!2$PW7!P$¸cƒê_žõ
! p&$$
OBZc)!:]<-[P,E3)!2$PW7!P$!Dq$c$$
•ñ
¾¿ñÝ

$
š§Sabcde
*
[X+}ƒ¢ßûƒÆ
Ç
$•–ŒÝÞ`‹
!Dq
$c$$
Ìà[X+}ƒäKA
¾¿
$
KASabcde
)
]M
CW
Sa€UM½­Sabc¼e
$
õ»[6Ÿl
I¶¼
$
@xÇ­„…
+&,
Ìà›Bbcde­¬
¢
*
mgdeISa€U‚­¥ƒ½1—
$
Sa
€UM½ðSabcdeN
$
ûSabcdeI
-%%)-
)$5
x
#
y ç
&$
èç

|
?-Ec&$$ ;-+ SD0A$ )$5
!!
•
!
wƒSabc8
P,E3)
Â
PW7
¸cƒê_‚®
!
&
Ez1$3j5
IWCEA!:]&
Ez1$3j5
ƒÏ
P,E3) PW7 P,E3)=PW7
Œ2}r ?—2}r Œ2}r ?—2}r Œ2}r ?—2}r
Y5
!! $c&(& z$c$4) 4c#)& z$c%&% $c) z$c$) $c#$( z$c$4 &c5# z$c%% 5c(5% zc%)
ßû
!!
$c() z$c$4

c&$% z$c)

$c44 z$c$)5

)c5% z$c)&

$c5$# z$c$%5

$c#5% z$c#4

[X+} $c&$ z$c$&
)
)c$( z$c4
)
$c)) z$c$#
)
c$## z$c$&#
)
c&4$ z$c#$
)
c(5 z$c)(&
)
!!
E
#
¢Y5ƒÆÇ

Dq$c$*
¢ßûƒÆÇ
)
Dq$c$!
•
)
+
)
•
)!
wƒSabc8
•–‚®
!
&
Ez1$3j5
IWCEA)!T7LXAQQB-0 -[B0 ZX-DLQ!
&
Ez1$3j5
ƒÏ
Œ2}r ?—2}r Œ2}r ?—2}r
Y5
!! $c$z$c$) $c4%z$c4) $c%z$c$$# $c#&4z$c$&%
ßû
!! $c)$
z$c$%

)c)
z$c)55

$c)5%
z$c$)4

)c&(
z$c)%

[X+}
$c5%
z$c$$5
)
c$&(
z$c$(5
)
$c#
z$c$$
)
c5#%
z$c4
)
M½SaH¯â_WÂSN¥½ñ¬
&
S⊼­
¥J‘
)
r[ñ3
$
kÖSabcI¢ì—_­
bc
$
òÃùB—©±ä
$
kbc¶¼º½­ŽÀÂ
»¼ZB†Ï¥­`ÄdN
)
ûgde冧ó
ô˜­Û¡1—$í
)
Ôde}~$äåŽÀ€U
‚ñ3ZB¥dN
$
%ûHI_S`×ð­Ñ
|¡–
)
‘å
$
Y_S`Sa€U`$Sabc
de­„…
$
YÂÃ}~¡‚_S`Sa€UZ
B¥­dN
)
bcde­+Ï
$
œBÊˀ?’_€
?
$
–7˜l¢
$
‚®deÊː_œì~2
ÝãAÂU«ÝãAµ·
)
kÖbcdeþZ†‡
¿­’_HIuµ8~­k¾M½žõÓ
R;2
åu:zÅ©ûʽ
$ l)$$ CL
4:éÒü

R;2
€ô
)
‘å‚®
R;2
€ô­ñòêI‚
®de­œHô
+5,
$
7˜‚®de’_†‡­ñ
òÐì~ìÕ[Õuoµ9M­
KFIG
’€
€ƒ8~
!IF;TH
ñò
+#,
Â
R;2
€ô/(Ñ0
êU1ò
+%,
)
딵ì~
IF;TH
ñò‚®Sadebc
$
$
~2A‚]ìžõ­bc
)
Ö»„…lü
$
€USa$debc—×Z
B*+¿
)
€UJbcdeåY|]k¾
$
de…
dÖ»¼JÂÑ J
)
딵$ºß

ϖ
IF;TH
žõÝàdebcÐQüÖ»¼‰Ç­€UJ
$
»
¼JÂÑ Jde­bc¤YÇÀ
$
Y5ƒ¶ïøÏ
q¿bc
$
ßûƒq¿bc—×ÇÐ
$
¢Y5ƒ¤Æ
{_†ÝÞ
!Dq$c$$
[X+}ƒôÇßûƒÝÞ
ŽÀ
!Dq$c$$
•ñPQRŒýST¶UVWXT
ƒñäÝÞ`‹Sabcde
$
å[X\]^:Zß
û$^”ð6ƒñ­ÔdeÅ~
)
[¤Ÿl
P,E3)
@Ýu^ÚkŽ
$
„¢8ӂ
$
)u
O
+,
”KA³äzbcõ
,VX-.A<$<6U-<
­O
+(,
­Å~ûZB‚¢de

&
QlbcEò­Å~
$
傢€U€ÕLM­
bcdeÝÞ$lE¥Å~
+$,
) PW7
¢
P,E3)
B
&5k
+>¿m¢
P,E3)
ʽ_öDzÚ¶€
$
ÒÅ
~KA
P,E3)
åä
$
LMde­l’
+,
) 9WDXAX
1
+),
^”gWùúFõnzʚóåÖcÓ­
PW7
åy–dekOGßl’_
$

PW7
Ø
Dzʽm&¶–³äzb‘É
$
і]l’bc
õ
<
Ú³äz­O
$
LMbc­de
)
딵„…lü
$
ßûƒ
P,E3)
­•–Ýދ
ÖY5ƒ
!Dq$c$$PW7
­•–ÝÞdÖY5ƒ
!Dq$c$*
[X+}ƒ
P,E3)
­•–ÝÞdÖßû
ƒ
!Dq$c$$PW7
­•–ÝދÖY5ƒ
!Dq
$c$)
¥ñPQRŒýST¶UVWXTƒñ$
LMÔdeŽ‘
C,E3)
­•–
$
KAËdeŽ‘
CW7
­•–
)
ßûƒ
P,E3)=PW7
ÝދÖY5ƒ
!Dq
$c$$
[X+}ƒ
P,E3)=PW7
ÝÞdÖßûƒ
!Dq
$c$$
¢
20U-0QQ-0 P
1
+4,
Â
@W0ZIR
1
+&,
„…
lü[½
$
•ñPQRŒýST¶UVWXTƒñ
j”ä¿*GdeŽ‘¢ÔdeŽ‘­¤\Å~
$
%ûKAbcde
)
I¬¢ÂÁmde­¥‹Œ#[
$
Ide­Ëá°
$
åbcdeÝÞ$ÐÖuS¾G
$
m¢de­Êˆ‡}~¤¥
+5,
$
k
P
9M­ÊiîìIbcdeÝÞ­$SM#
)
-%)-
À/%1
#
PQRŒýST¶UVWXTƒñY:ûZ[X\]^_S`ßûSabcde”¤¥‹Œ•–­fg
õJ
!GX-,WQLWQA3(
­ÊšóåÖ
c—$
$
Ùbcy–deku<–
$
@ݳäz¢
£
$P,E
ùù‹ŒÅ~å³äzM½
<6U-<
­O
$
GX-,WQLWQA3(
y
<6U-<
¢de‹Œk¾‘«

!WL-LU-QBQLX-UAWQAW,UBeWUB0Z[W,U-X3$2LW[3
]¶Ê
½­deÚ¶z
!WL-LU-Q-.A
ø_k¾
$
k¾­
,
4) p$
4
­
¨~l
% p$
4
Â
) p$
4
­¾_
Ide­Ám
ð
$
ÒÅ~œRS€_¶bc8Ð.‹ŒÚ
¶z
*
k¾u8uµ
$
Uk¾
R;2
€ô‘«
&5
1
$
º½
R;2
©(¶Ê½
R;2
€ô
+#,
*
@݆
_F€_
2IGWQA&C
Ž
$
¶bc­hØåä
$
º
½bc8hq
)
ÉÎÅ~­B¶]•Iº½bc
ñ$í¿‚
$
ʽde
)
딵„…lü
$
ßûƒ
•–ÝÞdÖY5ƒ
!Dq$c$$
ÉGð
ù
ù$§¥MÅ~­É{
”ÒF{¹ì—
«
­•–
$
š§Sabcde
)
[X+}
ƒ
•–ÝÞ`‹ßûƒ
!Dq
$c$$
¥ñPQRŒýST¶UVWXTƒñK

­k¾
$
g¢åñÛ¡
š§bcde…F`­]•[½
)
•ñðPQRŒ
ýST¶UVWXTƒñY[X\]^:ZßûS
abcdeBJæÅ~
)

€?‚
#
+ ,!MDCWQBW^ H2$ ]AX0W0KA\_9$ PBQV-LXB,;]$ AUWEc]6L-7BW
W0K W,BK-QBQW,UBeWUA,WXKBW,.6-,6UAKAWUV UVX-DZV UVAC,E3) [W.BE6
LX-UAB0 P;:G4+S,cGX-,;WUE2,WK 8,B$ )$$)$((!)(#))5c
+ ) ,!
Î^w
$
ÂÃû
c
u+9,c
23
#
£f²’Qބ
$
)$$5c
+ 4 ,!_XCAS$>-KXBZDA\S2$WUALEWQ.B0-ZA0 W,UBeWU-XB0VBCBU-X3 !G2:3 A7LXAQQB-0 B0 WV63
LAX,V-EAQUAX-EA.B,L-X,B0A.-KAE-[W0ZB-LEWQU6+S,c>AQ$ )$$$ &(!)#&&c
+ & ,!
©ñó
$
ÕÔ
$

$
1
+
êٱΟtöþ¡ÐÄYŽSa
€U
=
—7EOSabcde­fg
+S,+
$%”µñ°
-.
$)$4$(!(#))(c
+ 5 ,!
×Û
$

$
ÏÛ}
c
/Þ¿bc¼e”„…ñò
+S,c
b
c’€-.
$((5$%!4#)%c
+ # ,!NA0ZYS$ HBCC6GcTeBKA0,A[-XWL-LU-QBQB0 WKeW0,AK VD.W0
WUVAX-.W# ,-3E-,WEB\WUB-0 *BUV B0UAXEAD^B03 CAUW3,-0eAXUB0ZA03
\6.A+S,c2.SGWUV-E$ ((5$ &%#)5c
+ % ,!PD/WH9$T0U.W0 9Hc9-KAQ-[.6-,WXKBWE,AEB0/DX6W0K ,AE
KAWUV B0 BQ,VA.B,VAWXUKBQAWQA+S,c+ ,!>-CC 9W,EAEW0 @$ 9B,VWAERcRAWUV C6KAQBZ0#LX-ZXW..AK
,AEKAWUV B0 ,WXKB-eWQ,DEWXCB-E-Z6W0K KBQAWQA+S,c>AQ$((%$!)#4%c
+ ( ,!MW0ZG9$ ]WD0QUAUAX2$ 2-^B]$ AUWEc9-XLV-E-ZB,WEW0K .-3
EA,DEWX,VWXW,UAXB\WUB-0 -[WKDEU,WXKB-.6-,6UAWL-LU-QBQKDXB0Z
V6LB7BWW0K XA-76ZA0WUB-0+S,cAQ$ )$$$$ %!)#c
+$,!HBD a$HBa$HBD bcT[A,U-[ZB0QA0-QBKA>A-0 ,WXKB-.6-,6UA-[
C,E3)=CW7ZA0AW[UAXBQ,VA.BWW0K XALAX[DQB-0 B0 XWUQ+S,cS]DW3
\V-0ZF0Be8,BIA,V0-E!9AK 8,B$ )$$)$))!$5c
+,!_VeWBa;$ 9BEB.W0 /3 A/A)*BUV W,-0QAXeAK V-.-E-Z$ PW7$ UVWUW,,AEAXWUAQLX-3
ZXW..AK ,AEKAWUV+S,c+),!9WDXAX9$ IQWB9$ 9AU\9$ AUWEc2X-EA[-XCW7B0 UVAXAZDEW3
UB-0 -[WL-LU-QBQB0 .-DQA.WQU,AEQ+S,cS:0eAQURAX.WU-E$
)$$$$ &!##)$5c
+4,!20U-0QQ-0 P$ 9WXUB0-D SAQ$)$$$$)5#!#5$c
+&,!@W0ZIR$ WL-LU-QBQ[-E-*B0ZBQ,VA.BWW0K XALAX[DQB-0 B0 KBAU3B0KD,AK V63
LAX,V-EAQUAX-EA.BW# XAEWUB-0 U- C,E3) W0K CW7 LX-UAB0QW0K
,WQLWQA34 W,UBeBU6+S,cHBLBKQ$ )$$)$4%!-c
+5,!9W/0-N$ S-XBQ:c2L-LU-QBQ$ -0,-QBQ$ W0K 0A,X-QBQ# W0 -eAXeBA*
-[,AEKAWUV+S,c2.SGWUV-E$((5$&#!#4c
+#,!R-0-eW0 9$ <-UAXINc<-0UX-E-[.BU-,V-0KXBWEB0UAZXBU6C6
P,E3) [W.BE6.A.CAXQW0K ,WQLWQAB0KALA0KA0U,AEKAWUV +S,+
PB-,VB.PB-LV6Q2,UW$ )$$&$ #&&!)=4# 44c

ƒ„-0
!
š
#
-(%)-