Abstract:Puerarin injection has been widely used for the treatment of cardiac/cerebral blood vascular diseases. The clinical statistical investigation had confirmed that puerarin injection can induce acute intravascular hemolysis, which effected the use of puerarin injection seriously. The review was focus on the research progress of the hemolysis of puerarin injection including the work in laboratory and clinic. The potential hemolysis mechanism and allergen of the puerarin injection were summarized and discussed.