Study on quality of life of asymptomatic HIV infected persons with traditional Chinese medicine-文献传递-植物通论文库

作者：徐立然,杨小平,郭会军,涂晋文,邓鑫,刘翠娥,伦文辉,王军文,王江蓉,谭行华,方路

摘要：目的: 探讨中医药辨证施治对无症状期HIV感染者生存质量影响,为改善HIV感染的生存质量提供临床依据。 方法: 采用随机、双盲、安慰剂平行对照临床研究方法,选择1 200例无症状期HIV 感染者作为受试者,随机分为试验组和对照组,比例约2:1。受试者入组后,根据中医辨证结果服用相应药物,试验组给予相应证型中药制剂,对照组给予相应证型中药制剂的模拟剂,每月辨证1次,每次根据辨证结果选用相应药物,使用PRO量表和世界卫生组织艾滋病生存质量测定量表简表 ( WHOQOL-HIV- BREF) 的中文版调查符合无症状期 HIV 感染者,周期为18个月,根据不同时段,分别计算治疗组和对照组的其生存质量总分及各领域得分,进行统计学分析。 结果: 由PRO量表可看出,6个月后治疗组的情况呈稳定趋势,与对照组比较有显著的统计学差异(P<0.05);从WHOQOL-HIV量表分析可以看出,与治疗前相比,治疗组生存质量变化值显著升高,而对照组生存质量变化值下降,2组间差异有极显著统计学意义(P<0.05)。2组组内比较均有显著统计学意义(P<0.05)。 结论: 中医药辨证治疗可以显著提高患者的生存质量,为艾滋病无症状期防治政策的制定和实施提供了依据。

Abstract:Objective: Study on quality of life of asymptomatic HIV infected persons with traditional Chinese medical, which can provide the clinical basis for improving the quality of life. Method: This study applied a randomized,double-blind, and placeb-parallel control designed method to select 1 200 persons in the asymptomatic period of HIV infection as the subjects. The subjects were randomly divided into the treatment group and the control group at the ratio of about 2:1.According to the results of monthly differential diagnosis of TCM,the test group and the control group were given homologue Chinese drugs preparations and model Chinese drugs.The total study period was 18 months. Using PRO scale and the world health organization AIDS determination of quality of life short scale form (WHOQOL-HIV-BREF) to investigate asymptomatic HIV infected persons, according to different times, we calculated the total score and each domain score of quality of life of the treatment group and control group, we did statistical analysis. Result: Form the PRO scale,we can see that the treatment group showed a trend of stability, compared with the control group with significant statistical difference (P<0.05) after 6 months; from the WHOQOL-HIV scale analysis, we can see that compared with before treatment, the quality of life of the treatment group was increased, the difference was significant(P<0.05), but the quality of life of the control quality of life was decreased, the differences was significant(P<0.05). Conclusion: Dialectical therapy of Chinese medicine can significantly improve the patient‘s quality of life, which can provide the basis for the prevention and control policy formulation and implementation with asymptomatic HIV infected persons.

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Study on quality of life of asymptomatic HIV infected persons with traditional Chinese medicine

中医药辨证施治对HIV感染者生存质量影响的初步探讨

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