目的：探讨益气破血中药预防骨科大手术后下肢深静脉血栓(DVT)的效果及可行性。方法：将70例行骨科大手术的患者随机分为中药组(35例)和西药组(35例)，术后第2天2组分别化验D 二聚体，并于第2天起中药组每日口服益气破血中药1剂，对照组每日腹壁皮下注射低分子肝素钙(速碧)4100AXaIU，连续用药7 d，于术后第8天化验D 二聚体，并行双下肢血管彩色多普勒超声检查，观察治疗前后D 二聚体的指标变化，观察术后是否有出血倾向及肺栓塞发生，并统计DVT形成的情况。结果：中药组用药前后D dimer差异有统计学意义(P<005)；西药组治疗前后无统计学意义，治疗组与对照组疗效无明显差异；中药组无1例发生DVT，对照组1例发生DVT(1/35)；中药组10例出现皮下瘀血(10/35)，西药组26例出现皮下瘀血(26/35)，两组具有显著性差异(P<001)，2组均无其他不良事件发生。结论：2组均有效的降低了DVT的发生率，益气破血中药预防下肢深静脉血栓形成是可行的。
Objective: To evaluate the efficacy and feasibility of the Chinese drugs for supplementing Qi and activating blood circulation in preventing DVT after big operations in orthopaedics and traumatology and observe the change of D dimer before and after treatment. Method: Seventy patients ranging in age from 39 to 94 years who were treated by big operations in orthopaedics and traumatology were divided into two groups randomly. Traditional Chinese medinine (TCM) group (group A) and western medicine group (group B). On the 2rd day after operation d dimer was tested from both groups and the patients in group A were given one dose of TCM every day and the patients in group B were subcutaneously injected low molecular weight heparins calcium (LMWH). On the 8th after operation d dimer was tested again from both groups. The parameters, such as the incidence of DVT and pulmonary thromboembolism, bleeding condition, were evaluated respectively. Result: The D dimer decreased in group A and had significant difference (P<005), group B had no significant difference, there was also no significant difference between two groups. DVT was found in 1 patient in group B (1/35). Petechiae were found in 10 patients in group A (10/35) and in 26 patients in group A (26/35), which had significant difference (P<005). Conclusion: Both the Chinese drugs and anti coagulation drug can prevent the incidence of DVT effectively, and Chinese herbs are feasible in the prevention of DVT.