含有吡咯里西啶生物碱的植物在传统医药中有广泛使用，其肝毒性引起广泛关注。作者综述了吡咯里西啶生物碱的药理作用、毒性和药(毒)物代谢动力学等方面的研究进展，以便为后期研究提供基础。［关键词］吡咯里西啶生物碱；药理作用；毒性；药(毒)物代谢动力学
Plants containing pyrrolizidine alkaloids were widely used in traditional medicine. Its hepatotoxicity is main toxicity as well known internationally. In order to providing some foundation for the future studies, the advancement on the pharmacologic actions, toxicity, and pharmacokinetics or toxicokinetics of pyrrolizidine alkaloids was reviewed.