Abstract:Objective: To investigates the mechanism of hypooglycemic effect of conduritol A of stems of Gymnema sylvestre. Method: Fourteen days later after administration, observation is taken on the change of these mice and rats’weight, the FBG, TG, CHO, SOD, MDA, INS, TNF in serum were also dectected with enzymology method and Radioimmuoassay mothod. Take the liver to determine the disposal of glucose. Take the pancreas to do the HE and immunohistochemistrial staining, and show pancreas islet β-cell. Calulate thymus, pancreas, splenica index. Result: Compared with diabetic model mice, high and middosage of conduritol Acould remarkably reduce fasted blood sugar in diabetic rats induced by alloxan (P<0.01). Significantly increase the level of serum insulin (P<0.05). Activity of SOD was obviously increasecd, and amount of MDA was obviously decrased (P<0.05). The amount of conduritol A disposal of glucose was obviously increased (P<0.05). Significantly increase thymus, pancreas, splencia index (P<0.01 or 0.05); inhibited the atrophy of thymus, pancreas, splencias of the diabetic rats induced by alloxan. Compared with diabetic model group, cell’ structure and form of conduritol A had been some way improved. The immunohistochemistry results showed that β-cells numbers of pancreas in each conduritol A group were more than those in the model group. Conclusion: Conduritol A could have an effect on regulating the metabolism of blood lipid, free-radical scavenging, enhancing the antioxidant ability, potentiating immune function. Promoting synthesis of hepatic to decrease fasted blood suger.