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期 刊 ：中国中药杂志 2008年 33卷 21期 页码：2442.

关键词：多成分中药；药代动力学研究；现状；思考；

Keywords:multiple components traditional Chinese medicine, pharmacokinetic study, current situation, consideration,

摘 要 ：针对多成分中药药代动力学研究的现状，作者对中药药代动力学研究的特殊性、研究难点及研究的意义进行了综述，并分别对单味中药、复方及有效部位中药、中药方剂配伍作用机制、中西药药代相互作用、中医“证”或西医“病”状态的药代规律、以及不同剂型的药代比较研究等方面的研究现状逐一进行了分析。结合《中药、天然药物注射剂基本技术要求》提出了一些思考和建议。

Abstract:Facing the current situation, the paper reviewed the specificity, difficulty and significance in studying the pharmacokinetics of the multiple components of traditional Chinese medicine. Some key points in present pharmacokinetic study were also analyzed respectively in this paper, including the pharmacokinetic patterns of the individual herb, the prescription and its active fraction traditional Chinese medicine, the mechanism underlying the integrative effect of traditional Chinese medicinal prescription, the interaction between traditional Chinese medicine and chemical drug, and also the different pharmacokinetic patterns in the pathological situations of “Zheng” in traditional Chinese medicine and disease in modern medicine and the differences caused by different drug preparations. In addition, some viewpoints and suggestions were also given together with the consideration of <The basic technical requirements for the injections of traditional Chinese medicine and natural medicine>.

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