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期 刊 ：中国中药杂志 2006年 31卷 24期 页码：2058.

关键词：欣肾胶囊；慢性进展性肾病；7/8肾切除大鼠模型；

Keywords:progress of chronic kidney disease, Xinshen capsule, 7/8 kidney removal rat models,

摘 要 ：目的：通过对大鼠7/8肾切除模型的研究,探讨欣肾胶囊对慢性进展性肾病的影响。方法：自动生化分析仪测定血尿素氮、血肌酐；血液流变仪测定血液流变学指标；考马斯亮蓝法测定尿蛋白含量；采用PAS和PASM染色观察肾脏组织学改变,并半定量欣肾胶囊肾脏组织学变化的关系。结果：模型对照组尿蛋白排泄率明显增高,肌酐、尿素氮明显增高,红细胞聚集指数、全血黏度值显著降低,肾脏组织出现明显的病理改变,与假手术组相比差别显著；欣肾胶囊药物治疗后,上述各项指标均有明显改善。结论：欣肾胶囊具有降低蛋白尿、降低肌酐及尿素氮、降低红细胞聚集指数及全血黏度值、减轻肾脏的各种病理改变的作用,可有效延缓慢性进展性肾病的病程进展。

Abstract:Objective： To evaluate the effect of Xinshen capsule upon the chronic kidney disease progress by the study of 7/8 kidney removal rat model. Method: The urea nitrogen and the blood creatinine level were estimated by automatic biochemistry analyzer.Hemorheological index level was measured by rheometer. Urine protein was measured by Coomassie brilliant blue.PAS and PASM staining was applied to observe kidney histology change, and semi-quantitative analysis was used to observe the kidney histology change.Result： In model control group, the urine protein excretory rate and the urea nitrogen,the blood creatinine level were up-regulated obviously, erythrocyte aggregation index and whole blood viscosity value were down-regulated significantly, kidney organizations show up pathological change evidently, and leave surgical group compared the difference.After the treatment of Xinshen capsule, the above indicators are improving obviously. Conclusion： Xinshen capsule can degrade urine protein,the urea nitrogen and the blood creatinine level, and lower red blood cell accumulation and the whole blood viscosity, alleviate kidney various pathological change, the medicine can effectively delay the progress of chronic kidney disease.

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