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期 刊 ：中国中药杂志 1999年 24卷 04期 页码：238.

关键词：脑膜微循环；兴奋性毒性；脑保护；

Keywords:microcirculation of meninx, excitotoxicity, cerebral protective effect,

摘 要 ：目的：观察几种中药成分对脑组织的保护作用。方法：采用激光多普勒流量仪动态监测脑软膜微循环的变化以及大鼠大脑皮层神经细胞培养法，比较不同药物的作用。结果：葛根总黄酮、三七总皂甙、氧化苦参碱、山莨菪碱、小檗碱均能扩张麻醉小鼠脑膜血管，增加局部血流量；前四者同时还明显加快血流速度，其中氧化苦参碱的作用与山莨菪碱类似，主要使高频运动红细胞增多。三七总皂甙尚能拮抗Ｇｌｕ介导的兴奋性毒性。结论：葛根总黄酮、三七总皂甙、氧化苦参碱、山莨菪碱、小檗碱对脑组织均有一定的保护作用，但是作用的环节不尽相同。

Abstract:Objective:To study the cerebral protective effects of some compounds isolated from traditional Chinese herbs.Method:Laser microcirculation dynamic analyzer and cultured rat cortical neurons were used.Result:Pueraria lobata flavonoids(LPF),Panax notoginseng saponins(PNS),oxymatrine,anisodamine and berberine could dilate microvessels and increase the cerebral blood flow of anesthetized mice′s meninges.LPF,PNS,oxymatrine,and anisodamine also accelerated the flow of blood. oxymatrine,like anisodamine,increased quantities of erythrocytes in high frequency movements.PNS could protect cultured rat cortical neurons from glutamate neurotoxicity.Conclusion:LPF,PNS,oxymatrine,anisodamine and berberine have certain protective effects on brain, but differ in mechanisms of action.

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