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期 刊 ：中国中药杂志 1993年 18卷 08期 页码：500.

关键词：苦豆子总生物碱；耐缺氧急性心肌缺血；LD50；

Keywords:total alkaloids of Sophora alopecuroides, anoxia, myocardial ischemia, LD50,

摘 要 ：苦豆子总生物碱(TASa)可使小鼠对多种耐缺氧模型的耐受时间延长(ip<1/10,1/5LD₅₀/kg,P<0.05～0.01);对抗大鼠急性心肌缺血而引起的ST-T段变化(P<0.05);小鼠腹腔注射TASa测得LD₅₀为130.66±22.64mg/kg。

Abstract:To several anoxia mice models, total alkaloids of Kudouzi (TASa) can prolong their tolerance time (ip<1/10,1/5LD₅₀/kg, P<0.05～0.01). In the experiment of myocardial ischemia induced by pituitrin, TASa decreased significantly the ST change in ECG(P<0.05). The acute LD₅₀ of TASa by ip was found to be 130.66±22.64mg/kg for mice.

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