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期 刊 ：中国中药杂志 1994年 19卷 05期 页码：302.

关键词：桂附地黄丸浸膏；兔IgG；肾炎；肾小球基底膜(GBM)；环磷酰胺；

Keywords:Guifu Dihuang Pills extract, rabbit IgG, nephritis, glomerular basement membrane(GBM), cyclophosphamide,

摘 要 ：桂附地黄丸浸膏能使兔IgG加速型肾毒血清肾炎小鼠血清白蛋白升高,尿蛋白、血清尿素氮、血清总胆固醇降低,并能改善肾组织病变,其0.3,1.2g/kg两剂量与环磷酰胺0.015g/kg作用相当。

Abstract:The effects of Guifu Dihuang Pills extract were observed in rabbit IgG accelerated mouse nephritis model in-duced by nephrotoxic serum. The results showed that this preparation could increase serum albumin,reduce urineprotein,serum urea nitrogen and total cholesterol in serum,and improve the histologicaUesions in kidneys. Theeffects of GuiJu Dihuang Pills extract in dosages of 0.3g/kg and 1. 2g/kg were similar to those of cyclophosphamide0.05g/kg.

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