Abstract:Clerodendrum B(Ⅰ) at dosage of 100g/kg ip or sc for 7 days was shown to have antitumor effect on hepatic carcinoma and sarcoma 180 in mice. In the mean time, 100g/kg sc of(Ⅰ) interrupted 3.H-TdR incorporation into DNA of sarcoma 180 cells in mice, 100.10g/kg sc of (Ⅰ) could suppress the phagocytic activity of the peritoneal macrophage against the CRBC (chieken red blood cells) in mice, 100g/kg sc of (Ⅰ) also made the production of serum hemolysin less than one half of that of the control in mice immunized with SRBC. Clerodendrum C at 100g/kg could inhibit the growth of hepatic carcinoma in mice.