Abstract:The effects of water soluble extract of Liriope spicata on acute hemodynamics were studied in anesthetized cats. The results showed that LV dp/dt max was increased by 87%, whereas tdp/dt max was shortened by 28% after administration of WSEL (1.75g/kg, ⅳ). At the same time CO, CI, SI, and SVWI were increased by 146, 151, 153, and 194%, respectively, HR was declined slightly. SVR was reduced by about 48%. WSEL (0.79/kg, ⅳ) induced an increase of 38% in LV dp/dt max, 44% in CO, 50% in SI and a decrease of 20% in t-dp/dt max and 20% in SVR. Preliminary results indicated that WSEL increased ventricular contractile force and might increase cardiac pump function.