---

期 刊 ：中国中药杂志 1989年 14卷 05期 页码：47.

关键词：桂莪术乙醇提取物；桂莪术挥发油；四氯化炭；硫代乙酰胺；血清谷丙转氨酶；

Keywords:ethanolic extract and essential oil of Curcuma Kwangsinensis, carbon tetrachloride, thiacetamide, serum glutamic-pyruvic transaminase,

摘 要 ：桂莪术醇提物及挥发油对CCI₄、TAA引起小鼠SGPT升高有明显的降低作用,使BSP潴留量减少,相应肝组织病变减轻;对CCI₄损害和正常小鼠戊巴比妥钠睡眠时间明显缩短,对甘油三酯有抑制作用。桂莪术的毒性较低,口服LD₅₀醇提物为86.8±12g生药/kg,挥发油为1.10±0.08g/kg。

Abstract:The ethanolic extract and the essential oil of Curcuma kwangsinensis were found to be effective in lowering the elevated SGPT induced by CCl₄, TAA and BSP retention. Histological examination showed that hepatic damages of the extract-and oil-pretreated mice were less than those of the CCl₄, control group. The ethanolic extract helped to shorten sodium pentobarbital sleeping time in both normal and CCl₄ intoxicated mice. In addition, the essential oil exhibited an inhibitory effect on triglyceride accumulation in mice. The toxicity of the extract and the oil was found to be low: oral LD₅₀ was 86.8±12g crude drug/kg (ethanolic extract) and 1.10±0.08g/kg (essential oil).

---