Abstract:Objective To optimize the best preparation condition of Ganmao Tuire effervescent tablets by dry granulation.Methods The influence of roller pressure,roller speed,and water content of extract powder on yield and friability of particle diameter was investigated.Results The roller pressure,roller speed,and water content of extract powder had a significant influence on yield and friability of particles. Conclusion The preparation investigation of Ganmao Tuire effervescent tablets provides the reference technology to study and production for Ganmao Tuire effervescent tablets.