Abstract:Twelve compounds were isolated from the stem of Goniothalamus griffithii Hook f. et Thorns. Seven of them were identified as styryllactones: goniothalamin (1), 9-deoxygoniopypyrone (2), altholactone (3), goniodiol (4), goniotharvensin (5), goniofufurone (6) and 8-acetylgoniotriol (7). The other five compounds were identified as squamolone (8), pinocembrin (9), succinic acid (10), β-sitosterol (11) and stigmasterol (12) on the basis of spectral analysis (IR, MS, NMR and 2D-NMR). Among them, compounds 1, 2, 3, 5, 6, 7, 8, 9 and 10 were identified from this plant for the first time.