Abstract:Centipede, a Chinese traditional medicine for treatment of diseases, has been used for thousands of years in China in stroke hemiplegia, stroke, epilepsy, tetanus, pertussis, tuberculosis, burns, scalds and acute heart disease. Although people often encountered centipedes and suffered from its injury, the composition and function of centipede venom were poorly understood. In recent years, with the development of molecular biology and structural biology, great development has been made on centipede toxin, especially on peptide toxin researches. This review makes a brief summary of the recent progress on centipede toxins.