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作 者 ：邹礼根, 赵芸, 邱静, 潘虹, 姜慧燕

期 刊 ：核农学报 2016年 30卷 4期 页码：728-733

关键词：蜜梨；NFC果汁；清咽功能；动物试验；

Keywords:pear, NFC juice, throat-clearing function, animal experiment,

摘 要 ：为了评价蜜梨NFC果汁的清咽功能,通过大鼠棉球植入、大鼠足趾肿胀、小鼠耳廓肿胀3种动物模型试验,研究不同剂量的蜜梨NFC果汁对大鼠肉芽肿重、大鼠足趾肿胀率、小鼠耳廓肿胀率和动物体重增长的影响。结果表明,与阴性对照组(CK)相比,高剂量组(T3)大鼠肉芽肿净量减少23.47%,差异极显著;T3致炎后2、4 h和中剂量组(T2)致炎后4 h的大鼠足趾肿胀率分别减少14.5%、20.4%和16.5%,且差异显著;T2、T3小鼠耳廓肿胀率分别减少24.1%和27.8%,差异显著;而高、中、低3个剂量组的大鼠或小鼠体重增长量在试验期间均无显著差异。因此,大鼠棉球植入、大鼠足趾肿胀和小鼠耳廓肿胀试验结果均为阳性,且蜜梨NFC果汁对大鼠或小鼠的正常生长无影响,表明蜜梨NFC果汁动物试验结果为阳性,具有清咽功能。研究结果可为蜜梨清咽功能的开发利用提供参考依据。

Abstract:In order to evaluate the throat-clearing function of pear NFC juice, three different animal models including rat paw edema, cotton ball implantation in rats and auricular swelling in mice were employed to investigate the effects of pear NFC juice on the weight of rat granuloma, the rate of rat paw edema and mouse auricular swelling as well as the body weight of rat or mouse. The results showed that the net weight of rat granuloma in high-dosage group (T3) was significantly decreased by 23.47% compared with the negative control group (CK). Rates of paw edema at 2 hours and 4 hours in T3 group and at 4 hours in medium-dosage group (T2) were significantly reduced by 14.5%, 20.4% and 16.5%, respectively. Rates of mouse auricular swelling in T2 and T3 groups were significantly reduced by 24.1% and 27.8%, respectively. While significant influence of the pear NFC juice on the body weight of mice or rats in three groups during the whole experiment was not found. The results of the three animal experiments (rat paw edema,cotton ball implantation in rats and auricular swelling in mice) were positive. The adverse effects of pear NFC juice on normal growth of mice or rats were not found. In conclusion, the present study indicates that the pear NFC juice possesses the throat-clearing function, which can provide reference for the development and utilization of pear.

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