摘 要 ：用色谱技术对海南大风子(Hydnocarpus hainanensis (Merr.) Sleum.)枝条的乙醇提取物进行分离纯化,从中分离得到了6个化合物, 经波谱数据分析与文献数据对照,分别鉴定为coniferaldehyde (1)、mulberroside C (2)、mulberrofuran G (3)、mulberrofuran K (4)、morusin (5)和胡萝卜苷(6),以上化合物均为首次从海南大风子中分离得到。细胞毒测试结果表明, 化合物 1 对人肝癌细胞(SMMC-7721)和人胃癌细胞(SGC-7901)有弱活性,化合物 3 和 5 对SGC-7901有明显的抑制作用。
Abstract:The ethanol extract from the stems of Hydnocarpus hainanensis (Merr.) Sleum. was separated and purified by means of chromatographic technology, and six compounds were isolated. On the basis of spectral data, they were identified as coniferaldehyde (1), mulberroside C (2), mulberrofuran G (3), mulberrofuran K (4), morusin (5) and daucosterol (6). All the compounds were isolated from H. hainanensis for the first time. Compound 1 showed inhibitory activities towards human hepatoma cell line (SMMC-7721) and human gastric carcinoma (SGC-7901) cell line, and compounds 3 and 5 showed obvious inhibitory activities towards SGC-7901.