Abstract:RNA editing is a post-transcription phenomenon of gene processing and modification at specific nucleotide sites,which including nucleotide insertion/deletion or nucleotide conversion.RNA editing mainly occurs at genomic of mitochondria and chloroplast in higher plants.It has many important biology functions,but the mechanism of this phenomenon is still unclear.During recently years,the PPR proteins,might be as trans-acting factor of RNA editing,has been put forward and become a research focus in molecular biology.In this review,we introduced PPR proteins,RNA editing and possibility interaction pattern between PPR proteins and RNA editing.