Complex network analysis on dynamic change regularity of combining use of Chinese and western medicine in 27 678 cases with ischemic stroke in acute phase-文献传递-植物通论文库

摘要：缺血性中风病急性期患者在临床实践中常联合使用中成药和西药,该研究选择来源于14家三级甲等医院信息系统(hospital information system,HIS)中的27 678例缺血性中风病患者作为研究对象,以入院14 d内针对中风治疗的中西药物构建复杂网络,发现该网络具有无尺度现象,采用层次结构核心算法分别对急、危、一般3类入院病情患者入院1 d内,2~3,4~7,8~14 d 4个时间段的中西药物使用进行分析,发现3类入院病情患者核心中成药使用主要为活血化瘀和化痰醒脑药物,化痰醒脑药随时间变化在各类患者中使用逐渐减少。核心西药主要为抗血小板药、改善循环药物、神经保护药、抗凝药和脱水药,脱水药在入院病情为危的患者入院14 d内均为核心药物,而入院病情为一般的患者在入院3 d内作为核心药物使用,神经保护药的使用在患者入院7 d后逐渐下降。中西药物组合主要为神经保护药+活血化瘀药、抗血小板药+活血化瘀药、改善微循环药+活血化瘀药;化痰醒脑药在入院病情急和一般的患者中主要与神经保护药联合使用,而入院病情为危的患者多与脱水药联合使用。该研究以大数据分析和复杂网络建模发现缺血性中风病患者急性期中西药物使用的动态特征和药物联合应用特点,为缺血性中风病急性期治疗策略的制定提供参考。

Abstract:The acute phase of ischemic stroke patients are often treated with both Chinese patent medicine and western medicine therapies in clinical practice. This research included 27 678 cases of the acute phase of ischemic stroke came from 14 3A level hospitals. We collected data from patients with ischemic stroke who used both Chinese patent medicine and western medicine and were hopitalized within 14 days from hospital information system(HIS). Constructing complex network of Chinese patent medicine and western medicine were found to show scale-free network. Hierarchical structure of the core algorithm was used to analyze the characteristics of combined core Chinese patent medicine and western medicine in admission condition of "acute", "critically", and "general" of ischemic stroke acute phase patient within one day, 2-3 days, 4-7 days and 8-14 days. We found that the core Chinese patent medicine mainly used for activate blood and resolve stasis medicine, and phlegm eliminating brain refreshing medicine in all kinds of patients, but the phlegm eliminating brain refreshing medicine were used to reduce with time elapsing. The core western medicine mainly used for antiplatelet medicine, improve circulation medicine, neuroprotective medicine, anticoagulants medicine and dehydration medicine. The dehydration medicine as the core western medicine for critically patients within 14 days, but the patients for general admission as core western medicine within 3 days. The neuroprotective medicine was used to decreases after 7 days in hospital. Combination of Chinese patent medicine and western medicine were mainly for neuroprotective medicine+activate blood and resolve stasis medicine, and antiplatelet medicine+activate blood and resolve stasis medicine, and improve circulation medicine+activate blood and resolve stasis medicine. The phlegm eliminating brain refreshing medicine was mainly combined with neuroprotective medicine by urgent and general admission condition patients, and it was more combined with dehydration medicine by critically admission condition patients. This research found that the dynamic characteristics for the combination of Chinese patent medicine and western medicine of acute phase of ischemic stroke patients by big data analytics and complex networks modeling, and provide basis for acute phase of ischemic stroke patients, it provide basis for ischemic stroke treatment strategy making.

全文：) $5 x ) y â &$
ãâ
)&
|
U-@c&

$;-+)& JH,H.BHR$ )$5 )% #% «ðÏ$ñªò|óôõS$K ,öÅ÷ø_ù-úû JK ! RJ ) ! STT ) ! #$% ! ! UVW ) ! XY 4 c ,-,67É8 ,69:;<6É=>? ! @A$ %

$% )c Í2}ÍÉ w=>? ! Í2 #$)&% 4c ,-opæ 68 ! @A$

$&# wx #! ðÏ$ ñªò|óôí¶·#

$wÆÈu$ , K,

$ôcuÿ>¹ & ]L¡A£uBõW !Q-C\?MA@?0W-R.AM?-0 C6CMH.$ E:8

$ )% #% «ðÏ$ ñªóô:ò¬b

$cA£ & I 8Í¬$ ñ(ä

$K,ö ù-úû$
lÜôúû@BhbHÜb

$v)õSd!R¬ò * . * [ 4 A£ªóôA£ I 8$ ) p4

$& p %$ p& I &
O(N

$K,öu5m$
lÜ
4
A£ªóôõS

$,uÄ`ò»Ï_j _hM,ö$
_
hM,=O(ø_íwóô

$u÷æ$ ]
+
õSK,Ä`ò9Ï:¬,
*
yzæM,ö
*
Ñ¸Ç,
*
9Ô, ¢m
,

$¢m,íA£ªò.óôA£ & I 8oòõS,ö$
(A£ªò[óôíA£
4 I
8:òõS,öu

$Ñ ¸Ç,uíóôA£ % I ÷ææt +$ K,öCÈÄ`òÑ¸Ç,
k
»Ï_j,
*
9Ï:¬,
k
»Ï_j,
*
yz
æM,
k
»Ï_j,
,
_hM,íA£ªò [óô

$Ä`Ñ¸Ç,ÆÈu$
(A£ªò.óô_
¢m,ÆÈu
+
ôcº= ù-úûålÜðÏ

$ñªóôò|$ K,öuÅ÷£ ,öÆÈ
î

$òðÏ$ ñªò|(ä³ÐÚ ö°Ù
+

yz{
#!
ðÏ

$ñªò| , ù-úû ,$ K,öÆÈ
,
A£uBõW
,
,öÅ÷ø_

|})(
#!)

$53$ %3&

~T
#!
-Vqê7É;aOP
%4&%)!%%

$4$ #%
,GHIJK7=8?;07=LMNOP
NZ4

$4!V$ &

$##% ,-,67É8 ¶B=>hYÝoÙ;aOP <])$ &

$# A #! ! #$ %
!
=>]
!
¶Bhmn
!
^_`a,69:bc§{=>
!GH@$$$##&$&&344$)!K3.A?@$IAMA.?0?0X5)1#4c,-.

A
#!
JK
!
¶B
!GH@$4#(44%#)#5!K3.A?@$ 6*-0@?0H1#4c,-.
30*9-5C 25/R01N+2+->8,802.>2+*,FF4+2L515L<-+1,/> 06F0*:,2,2L <8506
34,2585+2.R58/512*5.,F,25,2)% #% F+858R,/4,8F45*,F8/10N5,2+FZ2;LDH?

$ O:ZA0X
)
$ 8 ;^OH?3@H?
)
$ ]:KZA03.?0X

!
$ L^ F)

$VE^ 2;LZA0 4 !C!#$ %

$&$ ()*+#%,-#+.,/ % 01%%,+123%,%

$0/%+ 4,+356()0/%#23%,+17,%,#$ *%8%9

$%$

$0/%+, )C!#$ %

$&$ ()76#

$5#A9%.%9$ ;+1%+ ?%@.#%

$6()E,/(1(96$ ;+1%+ #

$)&$ 0/%+,
4CI+@6D.+1<(#F%

$+1$ *%8%9 $$$&$ 0/%+
-@:8/1+F/.!GQHA,TMH\QACH-W?C,QH.?,CMR-[H\AM?H0MCARH-WMH0 MRHAMHI *?MQ B-MQ MQHRA\?HC?0 ,@?0?,A@\RA,M?,H+GQ?CRHCHAR,Q ?0,@TIHI )% #% ,ACHC-WMQHA,TMH\QACH-W?C,QH.?,CMR-[H,A.HWR-.& 42@HdH@Q-C\?3
MA@C+DH,-@H,MHI IAMAWR-.\AM?H0MC*?MQ ?C,QH.?,CMR-[H*Q-TCHI B-MQ MA@?YHI *?MQ?0 & IA6CWR-.Q-C\?MA@?0W-R.AM?-0 C6CMH.!E:8+<-0CMRT,M?0X,-.\@H70HM*-R[ -W.HI?,?0H*HRHW-T0I M-CQ-*C,A@H3WRHH0HM*-R[+E?HRAR,Q?,A@CMRT,MTRH-WMQH,-RHA@X-R?MQ.*ACTCHI M-A0A@6YHMQH,QARA,MHR?CM?,C-W
,-.B?0HI ,-RHCMR-[HA,TMH\QACH\AM?H0M*?MQ?0 -0HIA6

$)34 IA6C$ &3% IA6CA0I 3& IA6C+DHW-T0I MQAMMQH,-RHTCHI W-RA,M?dAMHB@--I A0I RHC-@dHCMAC?C.HI?,?0H

$A0I \Q@HX.H@?.?0AM?0XBRA?0 RHWRHCQ?0X.HI?,?0H?0 A@[?0IC-W\AM?H0MC$ BTMMQH
\Q@HX.H@?.?0AM?0XBRA?0 RHWRHCQ?0X.HI?,?0H*HRHTCHI M-RHIT,H*?MQ M?.HH@A\C?0X+GQH,-RH*HCMHR0 .HI?,?0H.A?0@6TCHI W-RA0M?3
/4%&/
)

$5 x ) y â &$
ãâ
)&
|
U-@c&$$ ;-+)& JH,H.BHR$ )$5
\@AMH@HM.HI?,?0H$?.\R-dH,?R,T@AM?-0 .HI?,?0H$ 0HTR-\R-MH,M?dH.HI?,?0H$A0M?,-AXT@A0MC.HI?,?0HA0I IHQ6IRAM?-0 .HI?,?0H+GQHIH3
Q6IRAM?-0 .HI?,?0HACMQH,-RH*HCMHR0 .HI?,?0HW-R,R?M?,A@6\AM?H0MC*?MQ?0 & IA6C$ BTMMQH\AM?H0MCW-RXH0HRA@AI.?CC?-0 AC,-RH
*HCMHR0 .HI?,?0H*?MQ?0 4 IA6C+GQH0HTR-\R-MH,M?dH.HI?,?0H*ACTCHI M-IH,RHACHCAWMHR% IA6C?0 Q-C\?MA@+<-.B?0AM?-0 -W\AMH0M.HI?,?0HA0I *HCMHR0 .HI?,?0H*HRH.A?0@6W-R0HTR-\R-MH,M?dH.HI?,?0HkA,M?dAMHB@--I A0I RHC-@dHCMAC?C.HI?,?0H

$A0I A0M?3 \@AMH@HM.HI?,?0HkA,M?dAMHB@--I A0I RHC-@dHCMAC?C.HI?,?0H$ A0I ?.\R-dH,?R,T@AM?-0 .HI?,?0HkA,M?dAMHB@--I A0I RHC-@dHCMAC?C.HI3
?,?0H+GQH\Q@HX.H@?.?0AM?0XBRA?0 RHWRHCQ?0X.HI?,?0H*AC.A?0@6,-.B?0HI *?MQ 0HTR-\R-MH,M?dH.HI?,?0HB6TRXH0MA0I XH0HRA@AI3
.?CC?-0 ,-0I?M?-0 \AM?H0MC$ A0I ?M*AC.-RH,-.B?0HI *?MQ IHQ6IRAM?-0 .HI?,?0HB6,R?M?,A@6AI.?CC?-0 ,-0I?M?-0 \AM?H0MC+GQ?CRH3
CHAR,Q W-T0I MQAMMQHI60A.?,,QARA,MHR?CM?,CW-RMQH,-.B?0AM?-0 -W,QH.?,CMR-[H\AM?H0MCB6B?XIAMAA0A@6M?,CA0I ,-.\@H70HM*-R[C.-IH@?0X

$A0I \R-d?IHBAC?CW-RA,TMH\QACH-W?C,QH.?,CMR-[H\A3 M?H0MC$ ?M\R-d?IHBAC?CW-R?C,QH.?,CMR-[HMRHAM.H0MCMRAMHX6.A[?0X+
-_5> R01.8.!A,TMH\QACH-W?C,QH.?,CMR-[H, ,-.\@H70HM*-R[, M?-0, Q-C\?MA@?0W-R.AM?-0 C6CMH., IRTXA\\@?,AM?-0CI60A.?,A@6
.0,#!& %`TZDFWF**&!#%!
!!

$A,íðÏ$ ñª(ä

$B(é ê -.$
,xÿÍ¬ðÏ

$ñªÝl%[õé$
,

$ì$

$,³´ÔFG;¹ðÏ$ ñªò|
cë..÷óôu
+
à¼%

$,í$ AA£
KAA£o_þÒÓ

$¶·#$ ðÏ

$ñªóôwÆÈ$ K,ö

$`ìHíðÏ$
ñªò|
+
A£uBõW
!Q-C\?MA@?0W-R.AM?-0 C6CMH.

$E:8$ qW%ºØAäUsª«

$@B=Øº$
=X
m

$F;slÜtuî$
Hö»Aäº=

+
ù-úû
-).
!,-.\@H70HM*-R[
=qr
H,xÿ&Ý6º=Rî56
-4.

$ ¶¤³lÜßRù-Àõ$ tu
+
Áù
-úûqr
E:8
º=

$ðÏ$ ñªò
|A£ªëA£O(óô

$K, ö$
cº=lÜóô

$K,öuÅ÷£$
ò
%¡ðÏ

$ñªX$ K,öëÆÈ
,£ö

$òðÏ$ ñªò|(ä³Ð
Ú ö°Ù
+
!M
°ÿ!
!a!M
=ÿ>
Þ=ÿ>¹

$%$ A&£

$A¶·¸ [AU9 E:8 =c« -&.$
Ä`mó
ôr£¸ÞuB
*
uB
!

$A * KA * AÙu B * è7¦uB & åd + ÞUë` Ó56$ @Õ

$%$ A&£

$A¶·¸[A U`Óý¹+ßÝ !)$ ;-c+
!aM
=ÂAef
!aa!M
ÂA
!
KA0£

$â[ _ò & òm r£óô , x% 45 p(( * , óôr£ÄøBuBP * KAP AÙuBP 4 r=oxÑ + !aaM ef !& #~ óô , ¤¥HU òðÏ$ ñªóô

$o & òÏ½ª *& Ï ½d , Èéª$ ÈéB
&
0Ï
*
m
0Ï
*
/0
*
3
*
ÏµõWª
*
ñiSJ
ª
*
SÑeõ

óô
+
!aSM
=vÓ
!aSa!M
=
!
íKAP

$ðÏ$
ñª®Iúüé5m_

$t0 && 5)5 «ó ô=$
í

$KAP$ â[òðÏ

$ñªóô$
nÂAef

$tÂAòðÏ $ ñªóôt
4& &%)
«
+
!aSaM
=_
!
.î¬AÙuB5m_

$öfðÏ$ ñª(ähÀ,~

$o}e * ,ö * 2É&, * X¿Ô * ¡f,$
öfÉ(ä
AÙ

$og½ * 0£O, * â$
tó/,ö5m
_

$Rø$ ,K,
+
(K,
#
t,öW[
_ò@úü

$tr,öÈé , )$
,
#
tr,öÔ»ôÈé

$O,~ùq ¤Ä($
°,övÿC

$° ($ %,ö
)
!)

$x ¬$,5m + !aSaSM ^_= ! íx_=$ $ ö fðÏ$ñªÄ`{Nð±ª« $ öfª« = 4$ «óôA£ ! ]A£ $ h%$ öfª« = 5$ «óôxp !)$
x
)

$) x= $ h #$ :=ÂA )% #% «òðÏ$ñªóô = + /&%&/ ! § #)% #% «ðÏ$ñªò|óôõS$K,öÅ÷ø_ù-úû !a%M ÿ! cuðÏ$ñª(ä)nò & (³ & & A óô $ cðÏ$ñª$K,öuøB: ò¬b $ $K,öù-úû $ c)õ Sd!RA£ªóôA£ $) p4$ & p%$ p& I & O(NwÆÈuõS$K,ö + !a%a!M ÀÆ ! cÀÆ^_UBóôðÏ $ñª(ä,ö ) º,ö>pº $ í$öf K,K,CÈ $ ÀÆ÷¹Hò$,K ,~$,$,CÈuóôn« $ c:ò ¸[,öù-úû + !a%aM ù-úû ! cÀÆ_þ ) º$ K,öCÈ,öù-úû $ úû$c$,~ K,:ò)î $ Z[ ) ,öPFóôM ) r,öÆtu $ é.PFOuM ) r,öóô= $ íúûp$)îHò ôî¿Zé.« + o±Ê)îHº $ Ýô îg¹úû$S + !a%aSM )õSd! ! (9{·óôuU B$K,ö= , )R¯d ) r,öÆÈu « , *tUB,öCÈr:ò 7$ tUB,ö CÈt>:ò 7 I $ 9v=énCÈu« =5mtDeé , +õS,ösú + (O)õSd!D© 7 B JB ! K !IJ7 I $ $ ^_¼ B r ) º$K,öCÈ $ ì$ 7 B PP¼ B º ) º$K,öCÈt> $ eÈ Þ$OTò ), )Oc¯d)± $ ¼ B r ) º$K,öCÈ $ 9=^à , *u ;HMJRA* :pxà¬vc0 ) º$K,öCÈ5 mmî_ $ 9õS$K,ösú + M )± a!M óô¸ÞuB )% #% «óôÿ¹¹ & ]A£ $ ì$ 45 «óôÿ¹ # ]$AA£ $# 5&4 «óôÿ¹ ] KAA£ $ A£O(ò )$ )
x

y
5
zs
)

$x # y$
z
+
óôA£ªò
&
[

ô
)

$5%5 «$
Ý
%&c4&i

$A£ªò & ò ôt & ##4 «$
Ý
#c5i

$ªò & . ôt ) &&$
«

$Ý c)i, (ä )±&Aò:_$
t
) &

$«$
Ý
%%c45i

$(³ 5 5$ #
«

$Ý (c(i$
m·
5

$«$
Ý
c&i

$h )5) «$
Ý

$c(i+ óôx%:: 45 *$
:º
((
*

$Éox%ò !#%c$ 5 m(c%&
*
+
óôx%c
#

$p%& *ò:_$
t
%#
«

$Ý &)c5i$
ìò
%5 p(
*x%N
²ç

$t$ )(
«

$Ý )(c$ i

$&5 p5( *x%Nó ôt # 5(% «$
Ý
)4c4i

$45 p&& *óô ($ p

$*óôRò$ 5
«
!4c#4i

)#
«
!

$c(&i+ óô # &&$
«

$óô ( 5% «$
n«ò
c

$n+ aM ðÏ$ ñªò|

$K,ös O,övc)±$
óôA£
& I
8Í¬ðÏ

$ñª(ä$ K,öt
4
r

$ì$

$, r$
K,
5

$r + {·óôí & I 8uðÏ$ ñª,ö:]ò r $ :_ò ( r $ ,öu$· =ò 5!4$# r $ ì$}u r,ö(äðÏ$
ñªóôt
%)4
«
+
R¬ðÏ

$ñªóô$ , K,u>â
ÿº,ö5m

$lÜ$ ,u>â:ºò
±Ï@³´µ

$Ý )5c)i$
ìòhö

$Ý )c(5i$
K,

$u>â:ºòòEn$
Ý
#

$c#&i$
ìò¥i¯

$Ý )(c%)i$
óô

$K, öu·¹¼$
·ôP
+
P
!
ðÏ

$ñªò|$ K,ösP
GAB@H!GQHI?CMR?BTM?-0 -WMQH?C,QH.?,CMR-[H\AM?H0MC?0 A,TMH\QACH
;-c
K,

$, úü «= !i úü «= !i òEn # %&!#$ c#&
±Ï@³´µ
% &%!)5c)
)
¥i¯
))5!)(c%)
hö
#

$%5!)c(5 4 ¦¢ # 5&!))c)4 {³´µ 5 )%%!(c$ %
&
¼éF¾
5 %((!)

$c(5 MÔ³´µ 4 4#!c( 5 ³Â 5 45&!(c4& 4 )5!c% # Q=¡ 5 %%!c%$
Ï#@
) ((4!

$c % j & 4$ !5c5%
*¡Â³´µ
%

$&!#c# MÁc & )$ 4!5c(
ËÌWÂ³´Ô
#)4!5c#
(
_4 &&#!)c&5
Ï~@
)#%!&c5

$:6FÉ 4$ ()!c%
S@n
!&c

$& !! óô & I 8Í¬ðÏ$ ñª(ä

$K, öuRt )4$
ì

$,R $ r $ K, R 4 r $ $,R$»Ï_jÔ,öu:_ $ Ý %c4(i$ ìòRÝêÔ $ Ý )c(i+ K, R$9Ï:¬,u:_ $ Ý %5c%(i$ ìòyz æM, $&4c)%i óôou $ ðÏ$ñªò |$K,öRs)P )+ /5%&/ )$5 x ) y â &$ ãâ )& | U-@c&$ ;-+)& JH,H.BHR

$)$ 5
P
)!
ðÏ

$ñªò|$ K,öRsP
!
¼
$
·

GAB@H)!GQHM6\HC-W.HI?,?0HI?CMR?BTM?-0 -WMQH?C,QH.?,CMR-[H\AM?H0MC?0 A,TMH
\QACH!M-\

$;-c K,$ ,
R «=
!i
R «=
!i

9Ï:¬,
)

$(%#!%5c%( »Ï_jÔ ) #(!%c4( ) yzæM, (%5!&4c)% RÝêÔ 4 5(4!)c( 4 ¤yz,$ )44!4#c(%
ÕÄ»ÏÔ
4 4(#!%c&#
&
Ï½«!,
% 5#!)5c5
É³ÏÌÔ
)

$#&!%c&# 5 9Ô, 5 5$ %!(c(

$mÔ !! )%!)c(( # ¢m, & #$ !#c##
R¡ÒÔ
%5(!)c%&
%
te,
) #&!(c5%
_hÝêÔ
54)!c()

ÑFG,
) #)!(c&%
ÑÝêÔ
&4!c&(
(
9õö,
5%%!5c%

$R»ÏÔ 4)#!c$
8M,
4

$)!c$ (
ÙÃVãÔ
)%4!

$c(( aSM ò|õS$ K,ös
)% #%
«óô

&
(³

&
&A

óôt
)# (#
«

$¸¹ )# (# «óô(äBðÏ $ ñªóôõS

$K,öu + A£ªòò?r£)nò(³ &Aóô t & &4) «$
u(äðÏ

$ñª,öt ) r$
ì@,ösP
4+
óôA£
I
8tu

$r,ö$
cÀÆ
!!
P
4!
A£ªòò?(ä&Aë(³óô$K,ö
sP
GAB@H4!GQHI?CMR?BTM?-0 -WMQH?C,QH.?,CMR-[H\AM?H0MC*?MQ sA,TMHsAI.?C3
C?-0 ,-0I?M?-0 W-R?.\R-dH.H0M-R,TRHAWMHRMRHAM.H0M
;-c

$, K, ,öúü «= !i ,öúü «= !i ±Ï@³´µ &4$ !4)c)%
òEn
) (4&!##c)

$) hö (#!)$ c))
¥i¯
5##!45c44
4
{³´µ
%%!%c&

$³Â 4%%!4c$ %
&
MÔ³´µ
##(!5c

$( Q=¡ 4(!)(c%# 5 #5$ !&c#%
¼éF¾
)

$!)%c)# # Ï#@ 5)!%c&$
¦¢
4(!)5c%

$% *¡Â³´µ 44$ !%c&5
MÁc
((&!))c&4

^ðk
)55!5c%5
j
(5#!)c5%
(
Ï~@
)#!&c%
_5#!)c)

$ËÌWÂ³´Ô )&!&c4 :6FÉ &#)!$ c&)
!!
³
#
{·óômOu_r,ö

$P}é0¼$
·K,

$, + ^_ ) º,ö>pº$
í

$öfK,K,C È$
u

$,$ ,~

$,K,CÈt B %%# rCÈ$
c

$r,ö:ò)î$
c
%%#
r,öCÈ:ò

$9ðÏ$ ñªA£ªò
òóôA£
I
8,öù-úû

$p + Lñêò$ ,

$gÿêòK, , Zïò#,Ou , {îV-ïNPPìÜ,öZ[_]$
ï_PPÊr,öìÜ,öÆÈ
u_

$ïlPP#,ÆÈu_ , íúû$ v¹õS·âòu_,ö~CÈ
!
p
4

+
p
!
A£ªòòðÏ

$ñªóôA£ I 8$ K,öù-úûp
a?Xc!GQH,-.\@H70HM*-R[ -W,-0I?M?-0 AWMHR?0 Q-C\?MA@W-R IA6
/#%&/
!
§
#)% #%
«ðÏ

$ñªò|óôõS$ K,öÅ÷ø_ù-úû
!!
p

${)îò,ö$
Zïé.ò
)
r,
öOu²

$)îHò{r,öìÜ, öÆÈut² + v¹úû$ S

$,u Ä`ò@B»Ï_j³´Ô$
o±Ï@³´
µ
*
{³´µ
*
hö
*
Ï#@
$
MÔ³
´µ
*
MàXn
*
ÝÞ

$kr ,öÄ`@BR¡Ò * _hÝê: , p$ ·¹ú
û

$mK,Ä`òòEn * j * ¦¢ * ³Â * ¥i¯ * Q=¡ * Ñ\ln * MÁc * M±à + @ÕðÏ$ ñª

$KA,úû$
O¬
)îH5m

$lÜº_=)îHÉw:$
]=
)îHäº

$)îHsíous$
@Bhb
HÜb

$Áô,öù-úûHhbHúû$
)îH
ousp
)

$ôpvÊ¬=põ + p )! ðÏ$ ñªò|A£ªòòóôA£
I
8
,öúû)îHousp
a?Xc)!GQH0-I IHXRHHC\-*HR3@A*I?CMR?BTM?-0 ?0 MQH,-.\@H7
0HM*-R[ W?XTRH-W-WMQH?C,QH.?,CMR-[H\AM?H0MC*?MQ sA,TMHsAI.?CC?-0 ,-0I?M?-0
AWMHR?0 Q-C\?MA@W-R IA6
!!
O)õSd!D©¯d
B
ò
%

$Á c¼ % · ) º$ K,öCÈ

$të 5 r,ö$
@sP
&+
c,öCÈðÏ

$ñªA£ª òòóô I 8õS,öúû$
p
4

$P 5+ íp 4 P 5 mc0$
A£ªòòóô
A£
I
8õS

$K,ö *$ ,t
#
r

$Ä`ò» Ï_j,ö _hM,ö , K, ( r$
Ä`ò9Ï
:¬,
*
Ñ¸Ç,
*
yzæM,
*
9Ô, ¢m
,ö

K,öÆÈu:_Rò±Ï@³´
!!
P
&!
A£ªòòóôA£
I
õS$K,ö
)
>pº
sP
GAB@H&!GQHWRH`TH0M?MH.CHMC-WMQH,-RH,?0HA0I *HCMHR0 .HI?,?0H-WMQH?C,QH.?,CMR-[H\AM?H0MC*?MQ
sA,TMHsAI.?CC?-0 ,-0I?M?-0 AWMHR?0 Q-C\?MA@W-R IA6
;-c

$, K, ! ~$ ,

«= ÷¹H
=i

±Ï@³´µ òEn
& (c4
)
{³´µ
!
òEn
&% (c&
4
±Ï@³´µ ¥i¯
&

$% (c & hö òEn 4(( (c$

$5 ±Ï@³´µ Q=¡ 4($ c

$# !!! òEn 4%% c5 % ±Ï@³´µ ¦¢ 4%5 c&# ±Ï@³´µ ¼éF¾ 44) %c&( ( ±Ï@³´µ ³Â !! )5 5c##$
Ï#@
!!!
òEn
)4& 5c)

MÔ³´µ òEn
)) 5c&
)
{³´µ
!
Q=¡
))) 5c

$4 MÔ³´µ Q=¡ )% &c($
&

!!!
¼éF¾
)& &c4
5
MÔ³´µ _)& &c4
#
±Ï@³´µ MÁc
(5 &c&

$% MÔ³´µ j (5 &c&$
µ òEn
+
vLÿ!

$R¬A£ªòò * . * [ 4 rA£óôA£ I 8$ ) p4

$& p%$ p&
I &
O(N8wÆÈu

$K,ö5m$
)±P
#+
íP
#
m

$A£ªòòóôõS$ ,
u£òíA£
& I
8~rø

$c»Ï_j ,òÄ$
cë@B_hM,ö

$=7O(ø_$
_
hM,uóô÷æ$]
+
õSK,Ä`ò9
Ï:¬,
*
yzæM,
*
Ñ¸Ç,
*
9Ô, ¢
m,
+
Q=¡
*
_£
% I
uóô

$] +$ K,öCÈc9Ï:¬
,
k
»Ï_j,ò:_

$ìòÑ¸Ç, k »Ï _j, * yzæM, ! o¼éF¾ * ¥i¯ k »Ï_j, + A£ªò.óôA£ & I 8õS$ ,
uÄ`ò»Ï_j,
!
{³´µ
*
±Ï@³´
µ

_hM,
!
MÔ³´µ

$í ) p# I O_ hM,uóô:_ + õSK,Ä`ò9Ï:¬ , * yzæM, * Ñ¸Ç, * 9Ô, ¢m,$
¢
m,
!
MÁc

íA£
& I
8o·¹õS,ö

Ñ
¸Ç,
!
1N
*
Q=¡

}í¼
% I
·¹õ
S,ö

$9Ô, ! ³Â íA£ 4 I 0Ü¹õS, /%%&/ )$ 5
x
)
y â
&

$ãâ )& | U-@c&$

$;-+)& JH,H.BHR$ )

$5 !! p 4! ðÏ$ ñªA£ªòòóôA£
I
8õS,ösú
a?Xc4!GQH,-RHAWMHR?0 Q-C\?MA@W-R IA6
P
5!
A£ªòòóôA£
I
õS$K,ö)îHs
GAB@H5!GQH0-I IHXRHHCI?CMR?BTM?-0 -W,?0HA0I *HCMHR0 .HI?,?0H-WMQH?C,QH.?,CMR-[H\AM?H0MC*?MQ
sA,TMHsAI.?CC?-0 ,-0I?M?-0 AWMHR?0 Q-C\?MA@W-R IA6
;-c

$, K, ,ú )îH ,ú )îH ±Ï@³´µ ) %( òEn ) 5$ 4
)
MÔ³´µ
5&
Q=¡
)(
4
{³´µ
#4(
¼éF¾
5&#
&

5(
¥i¯
&$%
5
hö
4((
¦¢
4%5
#
Ï#@
)4&
³Â
)5
% j j
_)&
j j
MÁc
(5
( j j
j
(5
ö

$+ õS$ K,öCÈcÑ¸Ç,
k
»Ï_j
, 9Ï:¬,
k
»Ï_j,ò_
+
A£ªò[óôA£
& I
8õS

$ ,Ä`ò»Ï_j, ! ±Ï@³´µ * {³´µ * hö * _hM, É³ÏÌ, + õS K,Ä`ò9Ï:¬, * yzæM, * Ñ¸Ç , * 9Ô, ¢m,$
¢m,Ä`íA£
4 I
8u

$(9Ô,Ä`íA£ % I 8u + õS$ K,
öCÈÄ`ò9Ï:¬,
k
»Ï_j,
*
yzæM
,
k
»Ï_j,
*
Ñ¸Ç,
k
»Ï_j,
+
A£ªò
*
.
*
[óôõS

$,uÄ `ò»Ï_j _hM,ö$
_hM,íw
óô

$uóô=O(ø_÷æ$ ]
+
õSK,Ä
`ò9Ï:¬,
*
yzæM,ö
*
Ñ¸Ç,
*
9Ô
, ¢m,

$¢m,íA£ªò.óôA£ & I 8o·¹õS,ö$
(A£ªò[óôí
A£
4 I
8:òõS,öu

$Ñ¸Ç,íóô A£ % I u÷ææt +$ K,öCÈÄ`òÑ
¸Ç,
k
»Ï_j,
*
9Ï:¬,
k
»Ï_j,
*
yzæM,
k
»Ï_j,
,
_hM,íA£ª
ò [óô

$Ä`Ñ¸Ç,ÆÈu$
(A£ªò.óô_¢m,ÆÈu
+
SM
Û
Sa!M
ðÏ

$ñªò|$ K,öÆÈc»
Ï_jòÄ

$C³dv Þ¸¹$ K,öÆÈuCÈ

$ù- úû õS,ösúÿ!$
lÜA£ª
òò
*
.
*
[óôwÆÈu

$KõS,ö t )% r$
ì$$,ò±Ï@³´µ
*
MÔ³´
µ
*
{³´µ
*

*
hö
$
Ä`ò»
/%&/
!
§
#)% #%
«ðÏ$ñªò|óôõS$K,öÅ÷ø_ù-úû
!!
P
#!
ðÏ$ñªò|óôõS$K,ösP
!
n)îHtDeé

GAB@H#!GQH,-RHIHXRHHC
O(
ò . [
õS

$, õSK, õS$ , õSK, õS$, õSK,
I
8 ±Ï@³´µ òEn {³´µ òEn ±Ï@³´µ òEn
MÔ³´µ Q=¡ ±Ï@³´µ 1N {³´µ ¦¢
{³´µ ¼éF¾ MÔ³´µ MÁc hö ¥i¯
¥i¯
j
q§¤ ¼éF¾
hö ¦¢
j
¥i¯ Ï#@ Q=¡
Ï#@ ³Â
j
Q=¡ MÔ³´µ _j
_j j j
³Â
j
MÁc
j j j
MÁc
j
j
j j j j
) p4 I
±Ï@³´µ òEn {³´µ Q=¡ ±Ï@³´µ òEn
MÔ³´µ Q=¡ MÔ³´µ òEn {³´µ ¼éF¾
{³´µ ¼éF¾ ±Ï@³´µ MÁc hö ¥i¯
¥i¯
j
1N ¦¢
hö ¦¢
j
q§¤ MÔ³´µ Q=¡
Ï#@ ³Â
j
¥i¯ Ï#@ ³Â
j
MÁc
j j
*¡Â³´µ MÁc
j
_j j j
_& p% I
±Ï@³´µ òEn {³´µ òEn ±Ï@³´µ òEn
{³´µ Q=¡ MÔ³´µ Q=¡ {³´µ ¦¢
MÔ³´µ ¦¢ ±Ï@³´µ ³Â hö ¼éF¾
hö ¼éF¾ hö MÁc ¥i¯
¥i¯
j
1N Ï#@ Q=¡
Ï#@ ³Â
j
¥i¯ MÔ³´µ ³Â
j
j
j j
*¡Â³´µ j
j
_j j j
_ p& I
±Ï@³´µ òEn hö òEn ±Ï@³´µ òEn
hö ¦¢ Ï~@ ³Â {³´µ ¦¢
¼éF¾ MÔ³´µ ¼éF¾ hö ¼éF¾
{³´µ ¥i¯ {³´µ r¸Y ¥i¯
Ï#@ Q=¡ Ï#@ MÁc Ï#@ Q=¡
MÔ³´µ ³Â
j j
MÔ³´µ j
j
j
j j j
:6FÉ
Ï_j,ö _hM,ö
+
K,Ä`òòEn

*
j
*
Q=¡
*
¼éF¾

$ ($ %ò
ðÏs

$(Û9 )$

$)$ Xd¿Á
+
t

-5.

E:8
%Ê]ÇÈL¡A£
4 %

$& «mr£óô,uB$
lÜ,=Ø·
¹¼

$·$ (äm

$,ò¾Ï%³´µ ³´W$
K,òòEn}& ¥
Wîj &

$Þ)±¿,Ò + v1óô$ A£ªò
*
.
*
[óôõS

$,uÄ`ò»Ï_j _hM,ö$
_hM
,íwóô

$uóô=O(ø_÷æ$ ]
+
õSK,Ä`ò9Ï:¬,
*
yzæM,ö
*
Ñ¸
Ç,
*
9Ô, ¢m,

$¢m,íA£ªò.ó ôA£ & I 8o·¹õS,ö$
(A£ªò[
óôíA£
4 I
8:òõS,öu

$Ñ¸Ç ,íóôA£ % I u÷ææt +$ K,öCÈ
Ä`òÑ¸Ç,
k
»Ï_j,
*
9Ï:¬,
k
»
Ï_j,
*
yzæM,
k
»Ï_j,
,
_hM,
íA£ªò [óôÄ`Ñ¸Ç,ÆÈ
u

$(A£ªò.óô_¢m,ÆÈu + Ùqóôª.$
Cc¬÷(äòÄ

$otu 8w * Ñ¸Ç$
íáù£% à.îÍ¬ð
/(%&/
)

$5 x ) y â &$
ãâ
)&
|
U-@c&$$ ;-+)& JH,H.BHR$ )$5
Ï$ñªÝ6wt(ä
+
@Õc)±m
$
ðÏ$ñªò|$
,uc»Ï_j,öòÄ
$
ò¬(ä
$
Xc_h
MÝê,
$
(K,uÝ0´Û9X,ö
u
$
$,K,ÆÈu_ò»Ï_j,
k
9
Ï:¬,
*
yzæM,
*
9Ô,
$
OÜP,Ó

$
»Ï_j$,_@ByzÏµÅè
*
Ïµ¼
ø
*
yzæM
*
9Ï#
*
9Å$vLe_:

-#3%.
$
ì+í¸Á~_<ðm¤@Õ=ÚÃ
:
$
ZH:=à[b
$
oºØu,öÝm¤
lá
$
Áí¶·u$C³dv56
+
SaM
ðÏ$ñªò|$K,öù-úûòh
bHúû
hbHúû
!C,A@HWRHH0HM*-R[
-3(.
H@B)î
HousÜbù-úû
$
Hù-úû[r
»
+
V8
-$.
yò
$
hbHúûÜbHúû$w
)î£
*
úûC^ñBCD C^$
}ÂÀõ¿Àù-úûÅ÷¹C^Õ1
+
hbHúû)îZ[H¡B{£þH
$
S
úûtåwºO@B{|£
-.
+
Þ@Õ¬ðÏ$ñªò|$K,öù
-úû$)îH5m
$
lÜ)îHsÁÈ
ous
$
lÜ$K,öù-úûòhbHúû
+
hbHÜb0Ü®ÁÙqÈ¹Þ,ö
ù-úû$,öoòÍ¬ôrª(ä,ö
$
ì(äHí$A~KA¶·#Û9Û.æ
$
.î
cÛ9X,ö
$
~OAá¶·èwtu
Êª$K,ö
$
Áìuâäº
$
íù-úû$
Ü)îHäº
$
(Oóôª+cìÜ,ö
$
u
â¹Û9X,ö
$
íù-úû$Ü)îH
ä:
$
Áí[úû$snÜhbHÜb
+
Õ1$lÜúû$w)îZ[wØ
$
v
)õSd!¤³õS$K,ö
$
é?¤³l
Ü,ö«(ÆÈuÀõ
+
SaSM
nC
Þ^_õS$K,öòwÆÈ,
ö
$
¤³Ü$K,öÆÈuÀõ
+
ZC

$oÂAv%_]º»L¡A£$
A£
ëFï£¬)±m¤B¿À
+
Þ=Ø
º

$=qíð±$
ÞbÂAÀÝ{Nð±=

$Õõ¦lÜìÜ=ð±ò=¸ð±$
Á¤
³[¶·o
+

?
#
- .!
ºÄ

$V c$ ñª

$A,>(DEÜk -S.c M$ A,

$)$

$(!#5c - ) .!8MR-XAMY8 EcK7\@-R?0X,-.\@H70HM*-R[C-S.c;AMTRH$ )

$$ &$!#)5# )#c - 4 .!;H*.A0 9KS$PARABvC?2O$DAMCJScGQHCMRT,MTRHA0I I63 0A.?,C-W0HM*-R[C-9.cNR?0,HM-0#NR?0,HM-0 0^?dNRHCC$ )$ #c
- & .!
x0

$E¯$
ä

$y$

c

$,4àÉ~ E:8& X =c«®¯ÿ! -S.c$ %

$,-.$
)

$4#!)$#)$c - 5 .! t $ §ÅÉ $ zþ $ c Ê£ )$ # p)

$xmr£ óô, -S.+ ,ö¼mª-. $)$ (

$!5# 4%&c - # .! º$
Æ7

$ê:{ $ c »Ï_j$,,Ó:56 -S.c ,öÉ~ $)$4$4#!##&c - % .! ¨| $ Æ}$
ºf
c
»Ï_j,,Ó:56
-S.c

$% ,ß$ )

$)5!###$4c - .!2OPARABvC?$ >2@BHRM$ ESH-0Xc9HA03W?H@I MQH-R6W-RC,A@H3 WRHHRA0I-.0HM*-R[C-S.cNQ6C?,A$(((!)%)#%4c - ( .!>2@BHRM$ ESH-0X$ 2OPARABeAC?cJ?A.HMHR-WMQH*-R@I3*?IH3 *HB-S.c;AMTRH$(((!&$#4$c -$.! V8 $ Æ¸ $ [& $ c ùÿ,öÍÓù-úûÿ! -S.c $%$A,uB-. $)$

$5!#(c -.! Ä~$
^Í

$¨ÀT c ù-úûÓÛëì -9.c 23 # fº0&$ )$$#c

-0
!

#
/$(%&/

Complex network analysis on dynamic change regularity of combining use of Chinese and western medicine in 27 678 cases with ischemic stroke in acute phase

27 678例缺血性中风病急性期患者核心中西药物动态变化复杂网络分析

相关文献