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作 者 ：冯天骄,张瑶,张占军,王永炎

期 刊 ：中国中药杂志 2011年 36卷 6期 页码：810.

关键词：功能磁共振(fMRI)；胆碱能药物；中医药；疗效评价；

Keywords:functional magnetic resonance image(fMRl), cholinergic drug, traditional Chinese medicine (TCM), drug evaluation,

摘 要 ：胆碱能药物是常被用于神经疾病的一类神经递质类药物,其药效评估研究中fMRI已经得到了广泛的应用。文章以胆碱能药物为例,系统归纳和总结了使用功能磁共振技术对胆碱能药物在与认知相关的记忆、注意、情绪、视觉研究方面的评价作用,并结合中医药的自身规律和用药特点,对其在未来中医药疗效评价,尤其是脑病治疗相关药物以及与情志调节相关药物的疗效评价中的重要意义。作者综述了近年来功能磁共振技术在神经药理学研究方面的工作进展。

Abstract:This article summarizes the progress of the application of functional magnetic resonance image(fMRl) on neuropharmacology. Cholinergic drugs are types of neurotransmitters which are usually used to treat neurological disorders. fMRI is widely used in the research of evaluation of cholinergic drugs. This article systematically summerizes the research of drug evaluation on memory, attention, emotion and vision by fMRI using the cholinergic drugs for example. Combined with the charactors and disciplines of traditional Chinese medicine (TCM), this article also makes a prospect of the application of fMRI on traditional Chinese medicine evaluation, especially the drugs on brain disease and emotional modulation.

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