免费文献传递   相关文献

Xanthone glycosides from Tibetan herb Halenia elliptica

藏药椭圆叶花锚中酮苷类成分的研究


目的:研究藏药椭圆叶花锚Halenia elliptica中酮苷类活性成分。方法:利用普通敞口硅胶柱色谱和半制备高效液相色谱等方法进行化合物的分离纯化与制备,并经超导核磁共振、质谱等现代波谱技术进行结构鉴定。结果:从椭圆叶花锚中分离得到6种酮苷类化合物,分别鉴定为:1 O [β D 吡喃木糖 (16) β D 吡喃葡萄糖] 2,3,5 三甲氧基酮(1),1 O [β D 吡喃木糖 (16) β D 吡喃葡萄糖] 2,3,4,5 四甲氧基酮(2),1 O [β D 吡喃木糖 (16) β D 吡喃葡萄糖] 2,3,5,7 四甲氧基酮(3),1 O [β D 吡喃木糖 (16) β D 吡喃葡萄糖] 2,3,7 三甲氧基酮(4),1 O [β D 吡喃木糖 (16) β D 吡喃葡萄糖] 2,3,4,7 四甲氧基酮(5),1 O [β D 吡喃木糖 (16) β D 吡喃葡萄糖] 2,3,4,5,7 五甲氧基酮(6)。结论:化合物4~6为首次从该植物中分离得到。

Objective: To isolate and identify the active xanthone glycosides in Halenia elliptica.  Method: The compounds were isolated by column chromatography, semi preparative high performance liquid chromatography and related techniques. Their structures were elucidated through spectroscopic analysis (NMR and MS).  Result: Six xanthone glycosides were isolated and identified as: 2,3,5 trimethoxy 1 O primeverosyloxyxanthone (1),2,3,4,5 tetramethoxy 1 O primeverosyloxyxanthone (2),2,3,5,7 tetramethoxy 1 O primeverosyloxyxanthone (3),2,3,7 trimethoxy 1 O primeverosyloxyxanthone (4),2,3,4,7 tetramethoxy 1 O primeverosyloxyxanthone (5),and 2,3,4,5,7 pentamethoxy 1 O primeverosyloxyxanthone (6).  Conclusion: Compounds 4 6 were isolated from this plant for the first time.