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作 者 ：汪浩,郑海文,赵之青,陈佩

期 刊 ：中国中药杂志 2009年 34卷 12期 页码：1582.

关键词：重症急性胰腺炎；柴胡四黄汤；细胞因子；

Keywords:severe acute pancratitis (SAP), Chaihu Shihuang soup (CHSHS), Cytokine,

摘 要 ：目的：探讨柴胡四黄汤对重症急性胰腺炎(SAP)血清细胞因子水平的影响。方法：60例SAP病患者随机分为治疗组和对照组(各30例)。治疗组给予柴胡四黄汤口服，1剂/d；对照组30例，给予大柴胡汤口服，1次/d，疗程均为7 d。测定两组患者治疗前后肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)和白细胞介素10(IL-10)水平。且设正常健康组30例。结果：2组IL-10水平均较健康组低。而TNF-α及IL-6较健康组高(P<0.01)。治疗后治疗组TNF-α，IL-6水平与对照组比明显降低(P<0.01)，IL-10与对照组比明显增高(P<0.01)，治疗组与治疗前对比P<0.01。结论：柴胡四黄汤能显著调节细胞因子水平，促进SAP早期恢复。

Abstract:Objective: To make a study of the effect of Chaihu Shihuang soup on blood serum level TNF, IL-6 and IL-10 of severe acute pancratitis. Method: Sixty SAP cases were divided at random into treatment group and control group (30 cases each). The treatment group were given chai-hu-shi-huang-soup once a day; the control group were given Dachaihu soup once daily, with both treatment period for 7 days. The tumor necrosis factor-α (TNF-α), interleukin level 6 (IL-6) and 10 (IL-10 of both groups were determined before and after the treatment. We also had 30 healthy cases. Result: IL-10 level in both groups was lower than healthy group while TNF-α and IL-6 were higher than healthy group (P<0.01). After treatment, the treatment group‘s TNF-α, IL-6 level were comparatively lower than that in the control group (P<0.01), and IL-10 level were clearly higher than that of the control group (P<0.01), comparison of the treatment group before treatment (P<0.01). Conclusion: Chaihu Shihuang soup can significantly regulate cytokine and improve early recovery of SAP.

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