Abstract:Objective : To investigate the effects of Naoxinduotai capsule on the markers of prothrombotic state as plasminogen activator inhibitor-1(PAI-1), von Willebrand factor (vWF) and alpha-granular membrane protein(CD62p) in essential hypertension patients of yang hyperactivity and blood stagnation. Method : The 62 essential hypertension patients of yang hyperactivity and blood stagnation were divided into Naoxinduotai capsue +perindopril group (treatment group, 30 subjects) and Perindopril group (control group, 32 subjects). Clinical symptoms, blood pressure and the blood plasma PAI-1, vWF, CD62p of the patients were observed. The blood plasma PAI-1, vWF and CD62p were measured by enzyme-linked immunosorbant assay(ELISA). Result: After 8 weeks treatment,in treatment group the clinical symptoms became better, and there was a significant difference with control group(P<0.05). Blood pressure was significantly degraded, but there was not a significant difference with control group. The blood plasma PAI-1, vWF, CD62p level was degraded ,and there were significant differences with control group in all the three makers (P<0.05). Conclusion : Naoxinduotai capsule can treat the essential hypertension patients of Yang hyperactivity and blood stagnation , and it has conspicuous advantages in improving the clinical symptoms and the makers of prothrombotic state.