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作 者 ：丁凡,张艳春,畅亦杰

期 刊 ：中国中药杂志 2010年 35卷 6期 页码：790.

关键词：类风湿性关节炎(RA)；三乌芍蝎汤；细胞因子(IL-6；TNF-α；IL-4；IL-10)；中药；

Keywords:rheumatoid arthritis, Sanwushaoxie decoction, cytokines (IL-6, TNF-α, IL-4, IL-10), Chinese medicine,

摘 要 ：目的: 探讨中药三乌芍蝎汤治疗类风湿性关节炎(RA)外周血细胞因子(CK)的变化。 方法 : 随机选择RA病人63例,其中治疗组41例以三乌芍蝎汤1剂/每天,分2次口服。对照组22例,予雷公藤多苷20 mg/次,每天3次;2组均连续服用60 d。同时观察药物对患者外周血细胞因子IL-6, TNF-α,IL-4, IL-10的影响。 结果 : 临床疗效、实验室指标治疗组明显高于对照(P<0.01,P<0.05);治疗组外周血4种细胞因子治疗前后自身比较,均有显著性意义(P<0.05,P<0.01)。与对照组比,治疗后IL-4,IL-10明显上调,有非常显著性意义(P<0.01)。 结论 :三乌芍蝎汤治疗RA,能调节外周血异常细胞因子,明显改善病人临床症状和实验室指标。

Abstract:Objective : To investigate the therapeutic effects of Sanwushaoxie decoction on alternations of serum cytokines in patients with rheumatoid arthritis (RA). Method : Sixty-three (63) RA patients were selected and randomly divided into 2 groups, with the treatment group administered with Sanwushaoxie decoction, one prescription, 2 times a day, while patients in the control group were given Common Threewingnut Root polyglycoside 20 mg a time, 3 times a day. The treatment was lasted for 60 days. Serum concentrations of IL-6, TNF-α, IL-4, IL-10 were observed during the treatment. Result : The clinical effecacy and the experimental indexes were significantly improved in the treatment group than those did in the control group (P<0.01, P<0.05). There were significant differences of serum levels of 4 cytokines within the treatment group before and after the treatment (P<0.01, P<0.05). The serum levels of IL-4, IL-10 were significantly increased in treatment group compared with those did in the control group (P<0.01). Conclusion : Sanwushaoxie decoction is an effective agent in regulating cytokines, improving symptoms and experimental indexes in patients with RA.

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