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期 刊 ：中国中药杂志 2007年 32卷 11期 页码：1064.

关键词：归胃经寒性中药；胃热证；胃机能；

Keywords:cold and cool Chinese herbal medicine of channel tropism of stomach, stomach-heat syndrome, physiological function of stomach,

摘 要 ：目的：探讨归胃经寒性中药对胃热证大鼠胃机能的影响。方法：用温热药干姜水煎剂连续灌胃大鼠15 d,造成胃热证模型。再分别以黄连、蒲公英、枳实水煎剂灌胃治疗10 d,用放射免疫分析法测定大鼠血液中与胃机能相关的生化指标血栓素B₂(TXB₂),6-酮-前列腺素F_1α(6-keto-PGF_1α)、胃泌素(Gas)、胃动素(MTL)、生长抑素(SS)。结果：胃热证模型大鼠血液中的TXB₂/6-keto-PGF_1α,MTL,Gas较空白组有显著性升高(P＜0.05),6-keto-PGF_1α则有显著性降低(P＜0.05)。分别予以黄连、蒲公英、枳实治疗后,6-keto-PGF_1α与SS有不同程度升高,TXB₂,TXB₂/6-keto-PGF_1α,Gas,MTL有不同程度降低。各寒性中药治疗组的药效以黄连组最强,其次是蒲公英组,然后是枳实组,且黄连、蒲公英、枳实的高剂量组药效均强于低剂量组。结论：归胃经寒性中药黄连、蒲公英、枳实可有效改善胃热证大鼠的胃机能,且疗效因药物的寒性程度不同而不同。

Abstract:Objective: Stomach physiological effects of channel tropism of stomach, cold &cool Chinese herbal medicine on rats with stomach-heat syndrome were studied. Method: Using water decoction of warm &heat medicine, Rhizoma Zingiberis to feed rats for 15 days continuously, causing the stomach-heat sydrome model, then decoction of Rhizoma Coptidis, Herba Taraxaci, Fractus Aurantii Immaturus was used to feed rats for 10 days, respectively. Biochemical indexes of blood reflecting the physiological function of stomach, including thromboxaneB₂ (TXB₂), 6-keto-PGF_1a, Gastrin(Gas), Motilin(MTL), and Somatostation (SS) were measured by radioimmunoassay. Result: Symptom of stomach-heat syndrome prevailed in body of rats after filled with decoction of Rhizoma Zingiberis, values of TXB₂/6-keto-PGF_1α, MTL, and Gas in blood raised up evidently, compared with the control (P<0.05), but values of 6-keto-PGF_1α decreased conspicuously (P<0.05). After treated with decoction of Rhizoma Coptidis, Herba Taraxaci or Fractus Aurantii Immaturus for 10 days, respectively. Symptoms of stomach heat syndrome were eliminated or alleviated, values of 6-keto-PGF_1α, and SS in blood elevated at different degrees, and those of TXB₂, TXB₂/6-keto-PGF_1α, MTL, and Gas felled down at different degrees. Difference of efficacy existed at different groups, group of Rhizoma Coptidis was the strongest, group of Herba Taraxaci was the second, group of Fractus Aurantii Immaturus was the third. Efficacy of medicine in groups with high dosage was stronger than those with low dosage. Conclusion: Channel tropism of stomach, cold and cool Chinese herbal medicine could improve the physiological functions of stomach effectively, and the efficacy concerns with the degree of their cold and cool characteristics.

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