---

期 刊 ：中国中药杂志 1998年 23卷 08期 页码：497.

关键词：大鼠；肝纤维化；

Keywords:Dahuang Zhechong Pills, rat, liver fibrosis,

摘 要 ：目的：研究大黄虫丸防治肝纤维化的作用。方法：运用大鼠免疫性肝纤维化模型，观察大黄虫丸对肝组织病理学、肝羟脯氨酸（ＨＹＰ）含量的影响。结果：大黄虫丸预防和治疗试验肝纤维化率分别为７２．７％和７１．２％，而模型组和秋水仙碱组肝纤维化率为９２．３％～１００％，尤其是大黄虫丸治疗试验组肝ＨＹＰ含量下降显著，与模型组比较Ｐ＜０．０５。结论：大黄虫丸有一定的抗肝纤维化作用，尤其适用于对肝纤维组织的降解。

Abstract:Objective:To study the effect of DHZC on liver fibrosis.Method:Immuno injured fibrosis in rats was induced by bovine serum albumin and DHZC was given during and after the model production respectively. Hepatic collagen contents,pathology of liver and serum hyaluronic acid were measured. Colchicine was used as control.Result:The shows that the liver fibrosis rates of the DHZC treated group during and after the model production were 72.7% and 71.2% respectively, while those of the untreated and colchicine group were 92.3%～100%.Compared with the untreated group,there was a remarkable decrease of hepatic collagen contents in the DHZC treated rats.Conclusion:DHZC have thus been proved helpful in reversing liver fibrosis to some extent.

---