Abstract:A design of second order orthogonal rotative regression was developed and field tested ,and a model for obtaining18kg/mu dry flower yield was simulated and built according to several better combinations based on the medel of totalsafflower dry flower yield. The optimal NPK-requirements for obtaining the above 18kg/mu dry flower yield are N:6~6. 5kg/mu , P2O5 : 10. 0~11.0kg/mu , K2O: 6.9~10.0kg/mu. These requirements may be adjusted rationally ac-cording to soil fertility ,manure sources ,and so on.