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作 者 ：卢诗瑶, 孙立洁, 袁丽霞, 朱薇薇, 姚建铭

期 刊 ：生物技术通报 2016年 32卷 5期 页码：26-33

关键词：纳他霉素；纳塔尔链霉菌；聚酮合成酶(PKS)；转录调节子；

Keywords:natamycin, Streptoyces natalensis, polyketone synthase（PKS）, transcriptional regulators,

摘 要 ：纳他霉素作为一种多烯大环内酯类抗生素，是纳塔尔链霉菌的次级代谢产物。它不仅能够有效地抑制真菌的生长，还能够抑制黄曲霉毒素的形成，因而广泛应用于食品防腐剂和真菌角膜炎的治疗等领域。纳他霉素首先由乙酸激活聚酮合酶（PKS）催化合成纳他霉素的骨架环，再由系列相关合成酶对其进行加工修饰，此过程涉及系列基因簇的表达调控机制，如转录调节子的调节、途径特异性调节、总体调控、交叉调节及胞内ROS调节等。完整的纳他霉素分子形成后由胞内转运子运出胞外。结合纳他霉素的研究进展，对其未来的研究方向进行了展望。

Abstract:Natamycin，a polyene-macrolide antibiotic，is a secondary metabolite produced by Streptomyces natalensis. It can not only effectively inhibit the growth of fungi，but also depress the generation of aflatoxin. Thus，it is widely used in the fields such as food preservatives，remedial reagent of fungal keratitis，etc. Skeleton ring of natamycin is firstly synthesized by the catalyst of acetic acid-activated polyketone synthase，and then modified by some other correlated synthases，involving the regulation and expression mechanisms of natamycin biosynthesis-related genes（i.e.，transcriptional regulator’s regulation，pathway-specific regulation，global regulation，and cross-talk regulation，as well as ROS regulation，etc）. A matured molecule of natamycin can be exported out of cells through intracellular transporters. Finally，perspective in the future has been proposed based on the research progress of latest reports.

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