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作 者 ：陈章权 彭世清 陈守才

期 刊 ：植物学通报 2002年 19卷 05期 页码：620-628

关键词：COP1；组成型光形态建成；基因表达；发育；信号转导；

摘 要 ：组成型光形态建成1(constitutively photomorphogenic 1,COP1)蛋白是一个分子量为76 kD的核蛋白，它由3个特殊的结构域组成即环形锌指结合域、卷曲螺旋形结构域和WD_40 重复序列，并含有一个核定位信号和一个新型细胞质定位信号，它是一个光形态建成的抑制子，是一个光调控植物发育的分子开关。当植物在暗环境下生长时，COP1蛋白聚集在细胞核内，抑制光形态的建成，而在光环境下，COP1蛋白则分散到细胞质中，解除其抑制作用，恢复光形态建成。COP1蛋白在细胞内的核质分布受多个因素的影响，核内COP1通过与特异转录因子相互作用来调节光形态建成。继从植物中分离鉴定出COP1蛋白之后，动物体内也发现有COP1蛋白的存在，提示COP1蛋白可能在调节动物和植物的发育及信号转导等方面具有共同作用模式。

Abstract:The COP1 (constitutively photomorphogenic 1) protein is a nuclear pro tein with a molecular weight of 76 kD,which contains three recognizable structural domains: ring finger zinc binding domain, the putative coiled_coil region, and the domain with multiple WD_40 repeats. The protein is a repressor of photomorphogenic development and a light_regulated developmental molecular switch. In the dark, COP1 accumulates in the nucleus and represses photomorphogenic development, and the light diminishes the abundance of COP1 and abrogates its activity. The nucleocytoplasmic partitioning of COP1 are regulated by a number of factors, COP1 acts as a master regulator of specific transcription factors within the nucleus, it interactive with some specific transcription factors and regulate the constitutively photomorphogenic development. A mammalian COP1 that contains all the structural features present in plant COP1 was isolated and identified, which suggest that COP1 may share a common mode of action between higher plants and mammals in regulating development and cellular signaling.

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