Abstract:Immune cell metabolism and its regulation are emerging topics in the field of research. The immune responses are usually accompanied with activation and drastic proliferation of certain immune cells in a short time and activated immune cells (e.g. B cell， T cell and different subsets， different types of innate immune cells， etc.) rely on the metabolic changes to differentiate， expand and execute their functions. Thus regulation of the metabolism of immune cells can affect the induction and outcome of the immune responses and associated immunopathological processes. This review focuses on the metabolic regulation of different T cell subsets， activated B cells， and iNKT cells， and how the adoption of different energy metabolism pathways affects immune cell functions， particularly in T cell subsets differentiation and their function.