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作 者 ：姜守刚;蒋建勤;祖元刚*

期 刊 ：植物研究 2008年 28卷 2期 页码：254-256

关键词：玄参；二萜；14-去氧-12(R)-磺酸基穿心莲内酯；

Keywords:Scrophularia ningpoensis Hemsl, diterpenoid, 14-deoxy-12(R)-sulfo andrographolide,

摘 要 ：利用正、反相硅胶以及各种色谱技术进行分离，经理化性质和光谱分析鉴定中药玄参(Scrophularia ningpoensis)有效成分。从玄参(S. ningpoensis)根的乙醇提取物中分离了8个化合物，分别鉴定为14-去氧-12(R)-磺酸基穿心莲内酯（14-deoxy-12(R)-sulfo andrographolide， Ⅷ）、肉桂酸（cinnamic acid，Ⅰ）、对羟基肉桂酸（p-hydroxycinnamic acid，Ⅱ）、丁二酸（succinic acid，Ⅲ）、β-谷甾醇（β-sitosterol， Ⅳ）、胡萝卜甙（daucosteol，Ⅴ）、葡萄糖（gluose，Ⅵ）、熊果酸(ursolic acid，Ⅶ)。Ⅷ为在玄参中首次发现的天然化合物。

Abstract:To search new anti-infective from Scrophularia ningpoensis. Various column chromatographic techniques were used for isolation and purification of the principles. The structures were elucidated on the basis of spectral data(UV,IR,MS,NMR) and identified by comparing with the authentic substance eight comounds were isolated from ethyl alcohol extract, They are identified as: 14-deoxy-12(R)-sulfo andrographolide(Ⅷ),cinnamic acid(Ⅰ),p-hydroxycinnamic acid(Ⅱ),succinic acid(Ⅲ),β-sitosterol(Ⅳ),daucosteol(Ⅴ),gluose(Ⅵ),ursolic acid(Ⅶ).Ⅷ was found first time in Scrophularia ningpoensis.

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