Abstract:Cultivation and promotion of herbicide-resistant GM crops significantly increased the efficiency of weed control and obtained great economic benefits. With further research, the unpredictability of alien gene in transgenic herbicide-resistant crops inhibited their development. According to the advantages and disadvantages of transgenic crops and non-transgenic crops, the current research status of herbicide-resistant crops at home and abroad was summarized systematically. The research methods and problems of non-transgenic herbicide-resistant crops were elaborated, and the future research challenges and strategies were further proposed.