Abstract:The bioactivity of avermectins to Chilo suppressalis and Cnaphalocrocis medinalis were determined with topical application in the greenhouse, its efficacy to C.suppressalis and C.medinalis and the influence to natural enemies were tested in the paddy fields. The laboratory bioassay results indicated that the LD50 values of avermectins to C.suppressalis and C.medinalis were 0.0199μg/g and 0.0252μg/g, respectively. It bioactivities were 37.48 times and 17.59 times as high as those of profenofos, 36.24 times and 21.42 times as high as those of chlorpyrifos, respectively. In a field experiment, control effects of 1.8% EC avermectin at the rate of 9-18 (ai)g/hm2 to C.suppressalis and C.medinalis were 74.08%-82.22% and 79.04%-87.19%, respectively, significantly higher than that of 50% EC profenofos and 480g/L EC at the rate of 360 (ai) g/hm2. The dropping rates of 1.8% EC avermectins at the rate of 9-13.5 (ai) g/hm2 to the spiders and Cyrtorhinus lividipennis were 18.75%-30.21% and 22.57%-33.94% on the 14th day after spraying insecticides, significantly lower than that of 50% EC profenofos and 480g/L EC at the rate of 360 (ai) g/hm2. The dropping rates of 1.8% EC avermectins at the rate of 18 (ai) g/hm2 to two kinds of natural enemies were 47.92% and 39.29%, respectively, equal to that of two chemical control insecticides.