Abstract:The sensitivities of 115 isolates of Phytophthora capsici collected from different regions to mandipropamid were tested by measuring mycelial growth rate. Ten resistant-mutants and 4 sensitive isolates to mandipropamid were used to study its cross resistance with dimethomorph, metalaxyl, azoxystrobin and cymoxanil by comparing their sensitivity to diverse active mechanism fungicides. The results showed that there were no significant differences among the EC50 of mandipropamid to isolates from Qingzhou, Shouguang, Dinxing and Gaocheng regions, and all those isolates were more sensitive to mandipropamid. The linear regression showed that there were no cross resistances between mandipropamid and other diverse active mechanism fungicides. After 11 successive incubation, the sensitivities of 2 of 10 resistant-mutants to mandipropamid could maintain their resistance inheritable stability with the EC50 of 1429.524μg/mL and 6872.476μg/mL respectively, but the other 8 could not maintain it. Our results indicated that the continuous use of mandipropamid was beneficial to development of resistance populations.