免费文献传递   相关文献

A cell membrane chromatography method for screening 5-HT receptor agonists from drug pair of Chuanxiong Rhizoma and Angelicae Dahuricae Radix

细胞膜色谱法筛选川芎-白芷中5-HT受体激动剂的研究



全 文 :)$5
s
)
t ô
&$
õô
4
w
P-Kc&$$ ;-+4 ?GQMOLM6$ )$5
dexI4Jyz{|
3
»}$
53BC
~¾€Ô 


!
!
Ù0
)
!


!
[:

c
Z“ز³a³´”µ
!
×Z Z“
%$$5&% )c
Z“9:\Å {Œ
!
×Z Z“
%$$##

mn
#!
ͱ÷€ ×P빌gë
$
#Æ
$53
þIW
!53BC
~¾Úͱ gë$θ¢†
(
uv@÷Œ‡u
ª¾öšµí!I4ŲH
$
*نdexI4Ô:HI4 FG҆ç«ÖŽFV@{|
3
»},Ê$ÈÔŲHƒ~
¾H†¢† -¾
$
g$Ø;Ñç÷‹$4Ú ˜Ž$¯
(
náâ¨ð
!)c&) j$
i
g&c& j$
i%
.-K,@
i

 
53BC
X
~
¾€Ô‚0û2/Œ˜,ˆ
$
àáæڌ˜$ þ@ž°
$
ÖíØ;ÑçÔ
53BC
X
~¾¢† ›ý©F×=/
!&c5( z
$c44 j$
i#
.-K,@
i
$
*͆ !R+§Œ‡Í±Œ˜v8‹,¡˜Ž
(
ö/¾2ˆB%F,ˆÔ~¾D
 H†¢†­2[Ë]†J
(

opq
#!
{|
)
»}
)
uª¾
)
dexI4
)53
þIW~¾
)
ͱ

rs)(
#!)$&3$3$

tuvP
#!
×Zz-{a~€jfst
43_T$$5#

wxAy
#!
!

!
¦w
!
Ç~a¿
!CGK$$)(#55455&&!W3.LHK$ NOJOH$5$&1)#c,-.
AG6.+6+;2,36G521+,01P2,:5? +6051/7129G2663-3P 5*YB26G6:012,P13-909
721+/2=P :,-21745=,3D-13P 85-V1+, ,3/A3P6.-G,6J,5=2-G,68,/-D
X]BOH

!
$ @P;L0
)
$ B]2;SEHG

$ XW;S9GH

!cTU,- O-1++)+564&J44. ,-. C&)% !4-+&4*$ TU,- %$$5&$ !;-,)
)c05,*+; =(5-(5!5-+5&$ TU,- A,4+4-% 8-95&1+3$ TU,- %$$#$ !;-,
*A;902,G0+!9HFMLH0GHU-0G-VIJG,-..-0 L0N VMGaOG0IK6G0,-O0IGMGN NHUGLUGU+CJGUION6[M-dGUIJLI53J6NM-76IM6[IL.H0G!53BC
MG,G[I-M$ [KL6UL0 H.[-MIL0IM-KGH0 IJG-,,OMG0,G-V.HFMLH0G+>LIUIMHLIO.*LUOUGN V-M[MG[LMLIH-0 -VIJG,GK.G.QML0GUILIH-0LM6
[JLUG!<98A H0 -OMG7[GMH.G0IU+CJG,GK.G.QML0G,JM-.LI-FML[J6!<9<3-VKH0G3BA@0HYGIJG,-.[-0G0IUVM-.IJGNMOF[LHM-VJHY-.LL0N 20FGKH,LGXLJOMH,LG>LNH7$ *JH,J H0IGML,I*HIJ IJGMG,G[I-MU-0
<98A+CJGNHUU-,HLIH-0 GaOHKHQMHO.,-0UIL0I!Q
X
*LU.GLUOMGN H0 LMLIUIMHLIO.=<9UO.LIMH[IL0$ L53BC
X
LF-0HUI$ ML0FH0FVM-.)+&) j$
i
I-&+& j$
i%
.-K,@
i
IJM-OFJ L<9<,-KO.0$ L0N IJG,L[L,HI6VL,I-MU
!Kf *GMGMG,-MNGN+CJGQ
X
dLKOG-QILH0GN VM-.IJG.-NGK*LU!&+5( z$+44 j$
i#
.-K,@
i
V-MH.[GMLI-MH0$ L0N IJGMLI.-NGK
-V.HFMLH0GH0NO,GN Q60HIM-FK6,GMH0 *LUL[[KHGN I-dLKHNLIGIJG[JLM.L,-K-FH,LKGVG,IU-VIJGNMOF[LHM+CJGMGUOKIUH0NH,LIGN IJLIIJG
<9<.GIJ-N ,-OKN QGLaOH,Z L0N GVH,HG0I*L6V-M,JLML,IGMHYH0FIJGNMOF3MG,G[I-MH0IGML,IH-0U- 9+&4+
*_6? T12/9+!JHY-.L) 20FGKH,LGXLJOMH,LG>LNH7) UIMHLIO.) ,GK.G.QML0G,JM-.LI-FML[J6) 53J6NM-76IM6[IL.H0GMG3
,G[I-M) .HFMLH0G
/1-#!& %`(]aEGXG++(&!#&((
!!
ͱ÷€ƒ ×P¥ë
$
L÷§fŽX´
 [ËԎ¥ë
*+
(
ͱ g뙚§×…-
$
‹ë¡™šMNáB-qV(
(
]Œ#Æ
$
53
þIW
!53BC
Úͱ gë÷ø$ôÌÎ
¸ ¢†
*)34+
(
ï÷™;$B
53BC
~¾€ÔË
“Ì©
$
‚Báâøð á”G’
$
á,R×wÞ
†
*&3#+
(
{|

»}-Ú÷ðîͱX/׆ ,
ÊD[
$
ڑ¼ƒ
*%3+

}|î
*(+
V]Œä†$‚B
,$(&,
]!
ŠV
#
dexI4Jyz{|
3
»}$
53BC
~¾€Ô 
àâ
$
ï{|
3
»},ÊÚðîͱ$-ÚçèŠ
*⢆™š^áÆ!
(
dexI4Jä÷ù÷s á¼gœ
$
%;T
$/,ˆÔx~¾;¹¢† B¾=.D
[
*$3+
(
u08Æ
$
öŒ˜ÈÚ¾2€ÃFŒ:²
Y H†¢†
$
‹šRÏOÔ䗠29Ž-
¾~¾Ï”¯ÄÇæHQ
*)34+
(
Ruv@÷Œ‡
uª¾x¡»šµdexI4ŲH
)
نdex
I4¹:HI4҆Ê{|
3
»},ʛh˜Ž$
¯ yzg$
$
*@÷/¾,¡uvʘŽ$¯
›hv8
$
g$‹$¢†Rͱ B%$¯
(
!M
ÝÞ
ÿ•
]4$$$
´%:HI4
!
k%»—šc‹D
E
)B<34$>
˜CžS‹´†FS™
!
”Â&Œ
O]&íBCDE
)>A@3_X$
˜uƒ™
!
άu
ûÙ&(.[BCDE
)
.³¿À
!)c$ ,.j4$
,.)
ýƒƒØŠ-؃±
!)c$ ..j$ ..(
{|

»}vw†‚K•4ŽÓŒ,´
$

Y¯@±²/øÂ&‡ˆ{|
E%)1+()/(;),-I<
4-% B-MIc
¹ » }
$-%5*(, .,;)&(, !?HU,JcG7
B-V.c DG0IJcGIB--ZcVc
 õöÒÛ
(
#$!‚
0û2
!
h<
$$#$43)$$&$
¹Ø;Ñç
!
h<
$)#3)$)&
ÊÛ憂$%æ,æÕ²
ú
)
Œ¿Ø¹
!_W` 3

$5
&
$$$~
†‚³%k´_
=BCDE
)
èÆ/I4Ã
!
k%­FDE
)
uv
†,/BÃ,
(
ò{
8[MLFOG3XL*KG6!8X
Œ‡
!5 g
%
ðc
$
r
)5$ F
†‚K•\@Œuv€ˆ$S
(
(M
†J
(b!M
áâԘ {|
3
»},Ê šµ
!
uvšµ
#{|
3
»},Ê
!{
ªÔ
#)
Ë,Ýr
5$$ F$
$
½,”2
4
!
$
²¨æM
) F
Í,
=.@)
${|
3
»},Ê
!{
îÔ
$)
Ë,Ýr
5$$ F$
û}÷
#
<
y
$
†
$c4k<9<3;L
-$¸¹:
$
$-$†
(
(b(M
Œ‡uª¾dexŲH šµ
!
ò{
8X
Œ‡¼FZÖª
$
dž<njà
$
dFuª¾
$
‡R
ýS Í¡;,$eɋf|ö
$
ÚýS 
$
.@
Í¡;,$X}ª
$
‡R«i8 Þ’¤À
$¤M%ª
(
“Û^†Jšµdex¹:
*&+
(
ÚXíCž >?ö‰¹:Z*uB
$c$5 F
ý1
˜_÷ Œ¿Ø¹ .³¿À$
$
¸¹
5 .H0
ª
$
2
‡÷Ð
(
uƒ;
$
dexŲH†
5 ..-K,@
i
AD8
¶:eÉ
5
!
$
×(Oг dex
$
´²‰‹u*
I4ƒ$
!)c$ ..j$ ..

$
‡R
& h
µ†
(
(bM
I4>?
!
dexI4>?
#
½€H/,8
AD8
¶:
! [B%c&)
ǣːoͅ[
)
›@
5
&
@)
ƒž
4% h)
½†
$c) .@,.H0
i
(
:HI4>?
#XHZ.L<

ƒ
!&c# ..j5$ ..$5
&
.)
½€H
#
èÆ
!23$ ..-K,@
i
¦!q«´¶
:
!
¦!È
[B)c5$D$
«xGŽ2ðeA
!$ g5
.H0$2
H/
45k)5 g)5 .H0$2
%$k))5 g
&) .H0$2
H­0Ú
%$k)&) g5$ .H0$2
Hö¢M
45k)5$ g#$ .H0$2
H/
45k)
ÕÖ®×
4$ 0.)
›
@
5
&
@)
ƒž
4$ h)
½†
$c .@,.H0
i
(
(b%M
Œ‡uª¾dexI4Œ˜ ÏâŠ{|
3
»
},ʠˆyz¯Ä
!
dexI4Ĭ*I4.
›ýMšGü²ª
$
‰Œ˜,ˆ
53BC
X
~¾€Ô
‚0û2ÊÛæ¶:
! j$
i&
.-K,@
i

8*I4
.
$
àá,ˆ dexI4k
)
jöç
$
‰{|
3
»}

!{
îÔèƶ:8*.Ì
$
v8Œ˜ z
›Ž
)
ƒª‰Œ˜ „|¯ÑШæ
$
èƲþ
$
›h´%:HI4¯Ä
(
âOšµí»Ø¹
!

³dex

I4ƒèOæ¢† «ÖŽ
(
(b#M
˜Ž$¯Ô
53BC
X
~¾;¹¢† ›ý©
F×=
!Q
X

÷G’,ˆÔ~¾Ï”ɾ Î¸t
W
(
Ò5J¦½ÇJ¹6¦Ï”†ø
*5+
$
BS
!

KUYT
[
Q
C
H
?
Q
?
B
1
*E+
/
Z
Q
C
H
?
B
1
!
‹$
$
Kf
/nÖ,ˆ þ@ž°
)Q
X
/nÖ,ˆ ›
ý©F×=
=.-K,@
i
)Q
9
/Œ˜,ˆ ›ý©F
×=
=.-K,@
i
)T
/nÖ,ˆÔxƒ‹~¾H†
¢†Oʒ þ@ž°
(
çnÖ,ˆ¹Œ˜,ˆ/â[-¾O
$
S
!
Ȝ_/S
!)#

KU
[
H
?
B
1
*E+
/
Z
Q
C
H
?
B
1
!)
uv$‰Œ˜,ˆ
53BC
X
~¾€Ô‚0û
2çè!)c&) j$
i
g&c& j$
i%
.-K,
@
i

¨1@÷dexI4ƒ
$
àáÚ|fG
(
çÐ
³›ýO
$
þ‰‚0û2nŠ˜Ž¯
!
r
5 j$
i&
.-K,@
i

¯@›¯Ä
$
àáæ 
Kf(
Ò5S
!)$
n
=Kf
ʌ˜,ˆ¨ð
*E+
.
¢k
$
b‚fG 
€(//I4ƒ¢=
B
U
=H
.
$
Òj€( çK//
‚0û2 
Q
X
K
(
‰ƒ~
)
¢=¦*S
!
$
$
n
,(&,
)$5
s
)
t ô
&$
õô
4
w
P-Kc&$$ ;-+4 ?GQMOLM6$ )$5
=!Kf3T
Ê
*E+
.
¢k
$
/ÈÖ혎¯Ô
53BC
X
~¾¢† 
Q
X
K
(
(b]M
 !R+§Í±Œ˜
!
…š !R+§
ͱŒ˜
$
Ŏ
8X
Œ‡
#$
N
$
¯&B
$
ܙ¯$
23?
a
$
v
$
N
( 2
/í»
D
/Œ˜
$)
ìdªÇ,
)<
/÷ŽÊÛ
$
“Û
5 .F,ZF
i
Ô
@Ásìd÷Ž,ˆ‚0û2
)X
/ªÔ
!{


W
/îÔ
!{

$?
/Ø;Ñç
$
v­*ƒ
(
š
ì,[!
$
¨1ì,
5 N(
^!ì,ª
4$ .H0$
×
2
Œ‡2
$
‹8r“Û
$ .F,ZF
i
¾ÎÔ@Ú
Œ‡(J

)J¹„*[ö89 !R+
$
…š !
R+§Í±Œ˜
$
ÙÚ´Vá&
$
ÅOŒ‡r1ß
à¹+Í!=
(
M
ÏO
b!M
Œ‡uª¾dexI4Œ˜ v8
!
uvg
$‚0û2Úí»Ø¹I4ƒ$ „|Oˆ/
)
.H0!
k
2$
éڌ‡uª¾dexI4ƒ$ „
|Oj0
%c5 .H0!
k
D$
ªYʂ0û2BB
E „|÷(
k
!
‚0û2Úí»Ø¹
!2
¹uª¾dex
!D
I4ƒ
$ „|
?HFc!CJG<9<,JM-.LI-FML.U-VUO.LIMH[IL0 -0 IJGQHL0Z
!2 L0N MLIUIMHLIO.<9!!
‰{|
3
»},ÊîÔ8*dexI4.Ì
$
v
8Œ˜ z›Ž
$
g$æÚ
45 .H0
ZB[BŒ 
„|
$
“}Æ,Ê$B˜Ž¯Ôdexƒ ~¾
B«ÖŽÏ”
!
k
)D)
„|¯Ú
4$ 0.
 ®×
ZB[ÆÇÐÑ
!
k
4$
‰‹ÑШæ
$
›h´%:
H¯Ä
!
k
)<$
Ò5½Çˆ F2ÐÑ«¬
$

ÊÛæI4kçÊ
!
k
)X$
!²Ø;Ñç÷äd
exI4Œ˜ìЪ [\·¸$¯
(
*†,ê‚
[_JÊËØ;ÑçÚ8*.Ì;ª P@
(
{
|
3
»},Ê$Ø;Ñç<µ1 
&ck
­´M
%5c#k$
ìÐøð/
5
½
!
k
)2$<(
k
)!
{|
3
»},ÊîÔ 
BA@<
k
!2$
ڌ‡uª¾d
exI4Œ˜$ „|
!D
nŠ„|¯ 
BA@<
k
!<
¹
Ø;ÑçÊÛ¶: 
BA@<
k
!X
?HFc)!CJGBA@FML.U-VIJGNMOF[LHM-VJHY-.LL0N 20FGKH,LG
XLJOMH,LG>LNH7$ L0N BA@<,JM-.LI-FML.U-V<9!< L0N IJGUIL0NLMN U-KOIH-0 -VH.[GMLI-MH0!X
k
4!
dexI4„|¯ F2ÐÑ34
?HFc4!]PU[G,IMO.-VIJG<9b(M
;¹¯Ä
!
½€H$Œ˜,ˆ‚0û2Ú
)c&) j$
i
g&c& j$
i%
.-K,@
i
å_O
$
Ø;Ñ
砄|OBáâøðæ_
$
é“ËøðÔ-¾
3
~¾ ;¹¾BQ
$
Pk
&(
«@F
$
nÖ,ˆáˆ
Ԍ˜,ˆ6¦Ï”Â[~¾
$
åԌ˜,ˆ?J
ϔ ~¾gÍ;¹
(
/ðד[&w
$
uv$0
*
T
*5+
$
猘,ˆ¨ð©1ŒŒO
$
-¾ „|
OáþgÍå_
$
“O-¾ 
Kf
K//
T
K
(
ä

*53#+
$
Ø;Ñç 
T
K/
c$5(
Ò5S
!$
,)(&,
]!
ŠV
#
dexI4Jyz{|
3
»}$
53BC
~¾€Ô 
ن
=!Kf3T
Ê
*E+
.
¢k
$
ÖíØ;ÑçÔ
53BC
X
¢† 
Q
X
/
!&c5( z$c44 j$
i#
.-K,@
i
(
LgN
¯@P#
)c&) j$
i
$c) j$
i%
$)c&) j$
i%
¹
&c& j$
i%
.-K,@
i
k
&!
áâ¨ð ‚0û2¢/6¦ÔO
$
Ø;Ñçڌ‡
uª¾dexI4Œ˜$ „|
?HFc&!WKOIH-0 [M-VHKGU-VH.[GMLI-MH0 -0 IJGMLIUIMHLIO.<9<
,-KO.0 *HIJ NHVGMG0I,-.G0IMLIH-0U-VUO.LIMH[IL0 H0 IJG.-QHKG
[JLUG+
!!
bM
 !R+§Œ‡Í±Œ˜¯Ä
!
Û#

ð
A
$
îԌ‡r1gÚOBªÔ_
$
+rO
@Œ‡+Í!=LÆǍ©
$
“}Æ,Ê$Ø;Ñ
çVm¶Ž$¯ÊͱBBŒùú
)
«@ 
$
îÔ
%O¸!RØ;Ñç
$
}Æ{|
3
»},ÊÈÉ
÷@÷Œ¯*⢆góK% 
(
%M
ò§
{|.B]±



7.a:M ¢†
$
÷ð
îͱކ½(X´ [Ë$,Ý
$
»}L÷ð
îͱ ×†,ˆ
*%+
$
ï{|
3
»},ÊÚðî
ͱ$-ÚçèŠ*⢆™š^áÆ!
(
uv

$
{|
3
»},Êðîͱ ¢†@NÔ
53
BC
~¾HQ
$
ÈÉ÷ÓÔØ;ÑçÚ8 Œ$¯*
⢆égó,%
)
Ö‹@÷˜
53BC
X
~¾Þ
ëßg¢OfÜ ™2¤ÀÑæéðîͱ
(
dexI4J‰PB~¾ dexˆ¡Ð³Ú
عƒ
$
ˆí„0B[ÑxšÔŽ?¹x~¾â¾
Ï) ˜ŽdexŲH
(
R¿v$
$
نöŒ˜
({|
3
»},Ê$
%
V@
3
¯F
&
ÇÔx~¾B«Ö
!!
#
!
Œ‡r1gÚOŠrO@+Í!=çB
!
#
Iz1$-w$
CLQKG!CJGL[[GLMH0FL0N NHUL[[GLMH0FIH.G-VMGN GLMUL0N IJGIH.GU-VU,MLI,JH0FJLN LINHVGMG0IIH.G!
#
Iz1$-w$
@ ì,Ô@
r1Ç$O
=.H0
r1ð(O
=.H0
rO@+Í!=
$ g4$ .H0 4$ g#$ .H0
í»
i $ $ )c5 z$c& )c z$c&
Œ˜
i )c z$c4 $5c z(c4 &c5 z%c5 &5c z5c$
‚0û2 5c$ .F,ZF
i
#c z$c% &&c z5c4 )5c z)c) %c& zc5
{|
3
»}ªÔ $c$ F,ZF
i
&c z$c5 #$c4 z%c$ &$c z5c# )c z4c$
{|
3
»}îÔ $c$ F,ZF
i
5c$ z$c# 5$c5 z#c 4)c z&c ))c z)c
Ø;Ñç $c$ .F,ZF
i
&c5 z$c% 5#c z%c5 4#c5 z4c5 )#c) zc(
ŽÏ” „|¯
)
*+͆J¦½ÇJϔ6¦
†ø¯ÄØ;ÑçÔ
53BC
X
~¾ ;¹¢†
$
u
v$Nˆí½€H$Œ˜,ˆ Ž‹¨ð¹æ
 þ@ž°
$
/Ȉֲ,ˆÔ~¾;¹¢† 
›ý©F×=
(
Ď
$
exI4ƒÎ$ŽBD´%:HI4w
)
+I4ƒ
 ˜ŽNɄ0
%) J
„
$
L[²øðƒ­´u
v ’†$R
(
ïo }ç
$
ö()«ÖŽE
$

Ž´
$
d¢÷øB/›æËÖ
$
É@Ú$,˜Ž$¯
 yz$gó‹!~
(

|h?}
#
* +!@G-0LMNH9$ 8IGH0GMCE$ 8,JGM2C$ GILKcCJGFK-QLKQOMNG0 -V
.HFMLH0G#.GLUOMH0FNHULQHKHI6H0 JGLNL,JGNHU-MNGMU*HIJ RB\fU
,KLUUHVH,LIH-0 -VVO0,IH-0H0F$ NHULQHKHI6L0N JGLKIJ!:BGLNL,JGALH0$ )$$5$ #!## &)(c
* ) +!bH.QLK>R$ ?MHGN.L0 2A$ PLKG/-WcWVG,I-VUGM-I-0H0 H0
.HFMLH0G[LIHG0IU*E+c;GOM-K-F6$ )$$ %%!# %5$c
* 4 +!AL0,-0GUH2c8GM-I-0H0 L0N .HFMLH0G# LMG,-0UHNGMLIH-0 -VIJG
,G0IMLKIJG-M6*E+cEBGLNL,JGALH0$ )$$$ (!5# )#%c
* & +!20I-0L,H?$ XGIMGLI.G0I-VL,OIG.HFMLH0G# LMGdHG*-VGLMK6H0IGMdG0IH-0 IMHLKU
*E+cW7[GMI>Gd$ )$$$ $!4# 45c
* 5 +!
V,À½
$
`%’
+
fû2šÔ Þ††J
*E++
uRAm
¹
$)$$%$ )!# )5+
* # + !CVGKI3BL0UG0 AcNMOFUV-MIJGL,OIGIMGLI.G0I-V.HFMLH0G# LMGdHG*L0N L0 O[NLIG
,4(&,
)$5
s
)
t ô
&$
õô
4
w
P-Kc&$$ ;-+4 ?GQMOLM6$ )$5
*E+c* % +!
ò!›
$
R­Ì
+
‘¼ƒ9å è8
---
§}‘¼ƒ

{|»
},Ê

¢³‘¼ƒL†
*E++
$%,æWX
$)$$$ (!# +
* +!
`5
$
$.ê
$
T,ê
$
V
+
{|»},Ê
!
‘¼ƒ

 ,¡¢
†
*E++
$,,¡Ô€
$(()$ !4# )+
* ( +!
b”5
$
!#
+
ͱ†Ô†,ë쏐
*E++
$%$,-.
$
)$$5$ 4$!4# ))#+
*$+!BG@<$ TL0FSX$ SG0F` XcW0Y6.LIH,L,IHdHI6L0N ,JM-.L3
I-FML[JH,,JLML,IGMHUIH,U-VIJG,GK.G.QML0GH..-QHKHYGN -0 UHKH3
,LUOMVL,G*E+c*+!BG@<$ RL0F8 <$ SG0F`Xc<-LIH0FL0N VOUH0F,GK.G.3
QML0GU-0I-LUHKH,LUOMVL,GL0N IJGHM,JM-.LI-FML[JH,,JLML,IGMHU3
IH,U*E+c*)+!XO B$ BGET$ RL0F8 <$ GILKc:0dGUIHFLIH-0 -V,LK,HO.L0ILF3
-0HUI3E3I6[G,LK,HO.,JL00GKH0IGML,IH-0UQ6LdLU,OKLMU.--IJ
.OU,KG,GK.G.QML0G,JM-.LI-FML[J6.GIJ-N*E+c20LKDH-L0LK
*4+!XO B$ >G0 E$ RL0F8 <$ GILKc,-.[GIHIHdGQH0NH0FL0LK6UHUV-M,JLML,IGMHYLIH-0 -V
!
2
LNMG0-MG3
,G[I-MQH0NH0FH0IGML,IH-0U*E+c20LKDH-L0LK!$# 4#)5c
*&+!B-O `?$ _J-O 9_$ EHL0F^ $ GILKc2dLU,OKLMU.--IJ .OU,KG=
,GK.G.QML0G,JM-.LI-FML[J63-VKH0G3FLU,JM-.LI-FML[J6=.LUU
U[G,IM-.GIM6.GIJ-N V-MMG,-F0HIH-0$ UG[LMLIH-0 L0N HNG0IHVH,LIH-0
-VL,IHdG,-.[-0G0IUVM-.IMLNHIH-0LKE*5+!_JHdZ-dL_$>OUUGdLPc;G*.LIJG.LIH,LKL[[M-L,J V-MIJGGdLK3
OLIH-0 -VNMOFQH0NH0FI-JO.L0 UGMO.LKQO.H0 Q6JHFJ3[GMV-M.3
L0,GKHaOHN LVH0HI6,JM-.LI-FML[J6*E+cE%$%!3)#&4c
*#+!;-,I-MC2S$ RLH0GM:R$ BLFGX8c2K-UIGMH,L0N ,-.[GIH3
IHdGNHU[KL,G.G0I-VNMOFUVM-.JO.L0 UGMO.LKQO.H0 Q6-,IL0-H,
L,HN$LUMGdGLKGN Q6JHFJ3[GMV-M.L0,GKHaOHN LVH0HI6,JM-.LI-FML3
[J6$ -0 LJO.L0 UGMO.LKQO.H03QLUGN UILIH-0LM6[JLUG*E+c
E*%+!

$
ڔ´
$
T5
$
V
+
¼Ë$,Š‹šÔðîͱ
*E++
$%$P,ˆ’†
$)$$$ )!)$# 5+

~-0
!
Š‹Œ
#
,&(&,