免费文献传递   相关文献

Anti-dementia effect of Tongluo Xingnao effervescent tablet based on urinary metabonomics

通络醒脑泡腾片抗痴呆的尿液代谢组学研究



全 文 :)$5
x

y ö
&$
÷ö
#
|
W-Rc&$$ ;-+# 2VXVYF$ )$5
!
`!
@¸¹Cº»¼1½¾‹OP¿Þ„…
£IV
!)
!
?KL
!)
!
¥ M
!)
!
ɋb
!)
!
!
NoN
4
c
ÒÓÚåvw1Çrs³¶·ûªX{|}~€#‚y
!
ÒÓ !Ñ
#4%%
)c
!Ñåmvƒç
!
ÒÓ !Ñ
#4%% 4c
åXåmnço
!
äu
$$%$$#

ij
#!
@¸¹Cº»¼
!?Hb;D?
‘>õI;ŽI÷欮œ¢Lº;
$
WB};çR`@–‚
$
Ç®íørÑ
2
#
)5345
HŽ¤N½¾ôIې‹OP¿Å˜Ùړ1½¾–‚I¹‹6
(
3¶·6
2
#
)5345
HŽ¤N½¾ÛôIø„…Ñ
†
$
©‚P¿Þ()„…\•Û
)2
#
)5345
HŽ¤N½¾ôIÛÖ@¸¹Cº»¼”•ۋO$P¿˜ÞOːױ
0_Öѧí¿
$
6#®ÌÍîP¿“.˜
$
IèøǓ.˜P¿×±0_ò‹@¸¹Cº»¼1½¾–‚
(
¶·ZÑ
‡H6#ØÙ
35$#3
á
)&3
”èÌèfÁ
!&3IAA2)
ÅÊ°Ö
43
ŸP¥Á.
&
ÝÌÍîP¿“.˜
$
r:aùÜä°8„
.dnq¿Ò
)
ŠÅʚ›“@ËP¿–—
$
Ã@¸¹Cº»¼Ñ
&
Ý8>î嘓s˜P¿×±¡ÉWB‹Ü\ˆ–
‚
(
3¶·ê‹
2
#
)5345
HŽ¤N½¾ÛôIB‹6‹OP¿ÌÍî8>î嘓.˜
$
@¸¹Cº»¼è6@P\ˆ®
P¿×±¡É®ëA1½¾–‚
(

klm
#!
@¸¹Cº»¼
*
P¿Þ
*2
#
)5345
*
ÇYÚH?–

no)(
#!)$53$3)#

pqrT
#!
X{
&
|ƒ„v…†

n‡|ƒˆ‰
)$4 b`$($4$$)3$$#%
åvv˜ÒÓÚ`¢n‡…„rsŠ‹‰Š
)$&?B$$$%#%

¡ÈɷʇæÖ×ØىŠ
)Bb[E4)UI3$$)#

stAu
#!
!
ɋb
!
¨©
!
§ÛÜÝåvŒŽŒv˜çrs
!?NR$$)##$$)4!D3.OPR$T-,7V1)#c,-.

Au~
#!
£IV
!
ŒÞrsZ
!D3.OPR$YP,QVO0*/_1#4c,-.
B41.+07,741.- 787H128C24N/>2 a.4N4-2 7873J7:H7411-<-:7024>3.4-3@ ,71-<242,.H:
ZD:UPO0X3_P0X
$)
$ I`2;C[P03/PN
$)
$ 92[V03F-0X
$)
$ bJ8QP3/V0
$)
!
$ Z2;C[-0X36O0
4
!c;*/4%<,-%(,-/,+7/(*6%(#2@**%-2 %$1 FDB3,#(%(#,$ ,+I-%1#(#,$%3!#$**0*1#2#$*@*,)-2*,+7#2)%$
A-,C#$2*$ !*$:1) #4%$ !#$%*
)c!*$:1) L$#C*-#(/,+I-%1#(#,$%3!#$**0*1#2#$*$ !*$:1) #4%$ !#$%*
4c!#$% 52%1*6/,+!#$**0*1#2%372#*$2*$ 8*#9#$: $$%$$$ !#$%
+B<:13-H1,!?-0XRV-bP0X0O-N\NSdNY,N0FFOGRNF!?Hb;D? PYO_OFN0FNT _SNY,SP_FP-0$*QP,Q ,-.NY\S-..-TP\PNT bP-0XXVPTN,-,3
FP-0 O0T ,O0 P._S-dN,-X0PFPdN\V0,FP-0cI-*NdNS$ PFYN\N,F-0 FQNVSP0N.NFOG-RPFNYO0T O0FP3TN.N0FPO.N,QO0PY.P0 FQNTN.N0FPO
.-TNRSOFYP0TV,NT G6QP__-,O._ORP0/N,FP-0 *PFQ 2
#
)5345
SN.OP0YV0,RNOSc?QNN7_NSP.N0F\-,VYNT -0 FQN,QO0XNYP0 FSO/N,F-S6O0T P03
FNS3SNROFP-0YQP_ O.-0XFQNVSP0OS6.NFOG-RPFN-\SOFYP0 FQNGRO0^ XS-V_$ 2
#
)5345
QP__-,O._ORP0/N,FP-0 TN.N0FPO.-TNRXS-V_ O0T FQN
?Hb;D?P0FNSdN0FP-0 XS-V_$ P0 -STNSF-TNFNS.P0NFQNPSY,QOSO,FNSPYFP,.NFOG-RP,.OS^NSYO0T N7_ROP0 FQNO0FP3TN.N0FPON\N,F-\?Hb3
;D?GOYN-0 FQN,QO0XN-\.NFOG-RP,FSO/N,F-S6-\FQNYNGP-3.OS^NSYc2,,-STP0XF-FQNN7_NSP.N0FORSNYVRFY$ 5$#3P0T-RNaVP0-0N$
&3Q6TS-76_QN06R_6SVdP,O,PT !&3IAA2$ ,-SFPY-RO0T 43FQP-YVR\OFNRO,FP,*NSN_SNRP.P0OSPR6PTN0FP\PNT OYFQN,QOSO,FNSPYFP,.NFOG-RP,
.OS^NSYc?QN6.OP0R6_OSFP,P_OFNP0 T-_O.P0NY6YFN.$ XRV,-,-SFP,-PTYO0T N0NSX6.NFOG-RP,_OFQ*O6Yc?Hb;D?,O0 O__OSN0FR6T-*03
SNXVROFNFQNTPYFVSGO0,NY-\.NFOG-RP,FSO/N,F-S6-\FQN\-VSGP-3.OS^NSYc?QNN7_NSP.N0FP0TP,OFNYFQOFFQNTN.N0FPO.-TNRP0TV,NT G6
P0/N,FP0X2
#
)534
P0F-QP__-,O._VYQOYPFY,QOSO,FNSPYFP,N0T-XN0-VY.NFOG-RP,.OS^NSYP0 VSP0N$ O0T DHb;D?,O0 O.NRP-SOFNTN.N0FPO
G6T-*03SNXVROFP0XFQNTPYFVSGO0,NY-\.NFOG-RP,FSO/N,F-S6c
/%)4/
)$5
x

y ö
&$
÷ö
#
|
W-Rc&$$ ;-+# 2VXVYF$ )$5
+ 7`@ Q230:,!?-0XRV-bP0X0O-N\NSdNY,N0FFOGRNF* .NFOG-0-.P,Y* 2
#
)5345
* 2R]QNP.NSoYTPYNOYN
02.#!&c%()FHRH,,(&!#!d(
!!
Âû±I4Ø1• # &
!2
#

‹b‘ÇYÚH

!2B
aùŒêÌ͔[
+,
(
ÉÇI4Ø1
•(dˆ*À±K6œ
$
r[6œ
2B
„…ž&
ga¤F¾
$
C®Â„…5œF¿
+),
(
·B„
…0K¶
2
#
)5345
ÑçR`@WBÏç‘îÙÚ
$
é
Çr)Àçø‘
2
# `@J¯
+43#,
$

2
#
)5345
H
Ž@ˤNÛ)‘„…
2B
lŒ‘’“,˜ùú
î‚ôI
(
Ç®Ñø
2
#
)5345
HŽ¤×3.dç
ɘçR‚%“‘Fš›P¿o‘‹OP¿
oîhŠ63jµ
(
p‡¶¨|„…
+%3,
0ç`
:’3ôII@P,/K‹@¸¹Cº»¼
!?Hb;D?
Ñ3ôIɘçR`@“®Œê0_
B‹Ü};–‚
$
ǮѮôœ”•‘’h¹X
Ç
$
Ã)Šìí‹OP¿Þ„…
(
éÇp¶·@
P
JLH<398
d‚()hE\•ÑƒÛ
)
½¾ôI
“,˜”•.¶·ۋO$P¿˜0_
$
6
|Ò$ùúKB/“.˜I6DŽE
2
#
)5345
HŽ¤
N¡½¾þ¢“,˜ôœ–‚‘’
(
!O
Ée
2XPRN0F)$$
C/OìüXó
!
)%Mº»
*
.P,S3@?@L3K
#ÊXó
!
™%s͞
*A-S-8QNR)$
D<3<

üX_
!
)%Mº»
*82D8I:;($ n$!
ï
%
YONYQP0
Uɕ&Û
*BZ35
ÛCH°#¾ó
!
çkÜÝ
*L:843(($3#
2´~;Z
!?ID>9@
8<:D;?:L:<*L2)$&H
UÈãi
!
iH´i&ó
àBCDE
*I)$5$>
CêËS‘
!
´ó
(
I4Ø1•¼¯
!2
#
)5345


8PX.O
DE
*
Ë
Á
)
ÓU
!
üX(

?=ø
LPYQNS
DE
*
Á„Þß
C
!
Mêh
$
íÉ
!
$%

’,BCDEåÅ
$
-<
$$4(2*
@¸¹Cº»¼¢p}ÕÞõ’
(
8AL
(
8B

$
™w}
$
°€
$ e))$ X$
=
øçkëභɘBCDE
$
ɘæþK<
+
‡
¶ÉéÊ
8‡
)$$3)&,(
(O
;F
(V!O
ôI’^
!
#ÛîâÉe.=#œCH°
#¾ói
$
^Å.îâ[‘†mdô
+,
(
œÛy
Åg$m3 
c5 ,.(
œ¨á.
4c$ ..$
âÿ
)c$ ..
ºÛïâl
$
@ˆØà†óÔ
4c4 ..$
6

,
H/.P0
h
Îê¤N
5
,
H
0•Úü#_
%) Q
53ü
2
#
)5345
$
¤N.6ó
) .P0(
ºFœSÿ¤
N.°b53ü
2
#
)5345

(
¤N.îâ[‘ã
Å
$
½¿
4 T
Ÿ“¤N
.H/^X
h
Ü‰›•

(
ˆÖ)Þ_–º¨
$
¤N.¯Ëåê
(
(V(O
Ãޓ¥,
!


¶.
$
@P
[
䖶·
ùúdôç`ÛI»ƒ°€Ð‘ÃøôIу
Þ
)
MêhуÞ
! c& .X/ ^X
h
)?Hb;D?
C
!%c5# X/^X
h
)
$
!4c% X/^X
h
)
´
!c( X/
^X
h

¯ËÞ
$
“²ˆÖ)ۖøimу
$

$
¹
*
QˆÖ)ÞÖôIуޣœ¥¦.°bå
ꍱ
$
®¶wÞ¥¦ì§,˜
$
¥,°bø
$ .H/^X
h
$


`
$
¥,OÆ^
&5 T(
(VdO
‹OŽ4äºê
!
¥,
&5 T
.
$
Ž4‹O
4
.H$4 $$$ S/.P0
h
ËS
$ .P0$
²iX
.H$ h$
g
ÑÒ#¹^‚
(
hE¨#ØpÎ~ZÒ
$) $$$ S
/.P0
h
ËS
$ .P0$
²iXO‹O
$c4 .H$
æ׺
°bÓU
$
Ð.‚ƒÂÎ
.P0$
œºØýwËS
$ .P0$
²iXO
$c5 .H
†mÃÄ
(
(V%OJLH<398
ýw
!
%Éì
$cf
ËÁJO
!23
ÓU
!E$
Ùò w
$$ e)5 .P0$(5f e&$f2*)5 e
5$ .P0$&$f e)$f2*5$ e#$ .P0$)$f e$f2(
%
ê
$c& .H/.P0
h
*
†ØË
5
,
H*
_~
4$ g(
D8:
ËÈ_ô:
#
gËÈnDô:
*
nD89
6WP5$ e $$$*
”U|%ê
H/.P0
h
*
”U|~
ò
$ g*
÷_àcÒ
GOS! GOSw i$
5
AO(
(V#O
a#îÃÄ
!
©‚º[Ø؄`ÃÄ
$9].P0N
)c
\wÃĿҐa#î
+(,
(
#wüXpZ÷b
JAÊXvpMò†mYìpÎÑ
(
ÑÎZÑÜ
Ý
$
œìºÃÄýw‚
$
º[ØؐMòpìÑÎ0
´ø
5f$
±ÝÃÄ¿Òa#îGH
(
(VO
=gºê
!
#wØpq
JLH<398
hEãJ=
g¤×
9].P0N)c
\w†mèù×g
$
²³ºê
$
ƒº¾›¤
)
ÑCÖ¤!C_–
$
wH_–܃\w
ª‚*‹qI¾g¶oEÑOº[Øp£0óÉ
ò]#æêÜ=
(
ÊX¤hK.ºê.
$
þç
síwØpwÊ~Ԑå¼=g
(
ÑÇ弆m
açÃÃÄÖÎD:`@ÃÄ
)
»=gW(Ö¯
$
@PJÃpÎÏÞÆ0o
$
¢qt~p?JÌÍå
˜“.˜
(
“.˜œ
9].P0N)c
$ª‚œù(`
/)4/
Èôi.
#
@¸¹Cº»¼1½¾‹OP¿Þ„…
@œwP¿˜=gá$†m£0¹ø
5 __.
_
æ˜#
! QF_#==.NFRP0cY,SP__YcNTV$ QF_#==_VG3
,QN.c0,GPc0R.c0PQcX-d(
dO

dV!O
wÞۋOtËÈ%p
!
wÞۋOØ
ptËÈ%p|p
$
@PÑÎè|
$
ôIу
Þ
)?Hb;D?
Þä\•ÑƒÞֈÖ)ÞÎÏ?B
‹Ü0o
(
®$
$
ôIуÞä\•ÑƒÖˆÖ)
ސ0oaù4$œ
5c$ e))c5$&%c5 e55c$ .P0*
?Hb;D?
ÞäôIуސ0oaù4$œ
%c5 e
))c5$4$c$ e4)c5$5)c5 e55c$ .P0$
g*‹
?Hb;D?
ÑôIɘ8>îP¿¹œ[#”¡
(
2c
\•ÑƒÞ
*Ec
ˆÖ)Þ
*ôIуÞ
*Bc
MêhÞ
*Dc?Hb;D?
Þ
(
p
!
wÞۋOtËÈ%p
LPXc!?-FORP-0 ,QS-.OF-XSO.Y-\VSP0OS6P0 NO,Q XS-V_
dV(O
,˜”•.wÞۋOP¿r°0_
!
©‚
A<2
Ñ=g•ºêÃËJA
) &#
ÝÊX¤
=g弆mvå¼açÃÃÄ
$
ZÑl·
$
\•Þ
$)
<Ö´¯ËÞ
&
<‹Oä®ûwØpWBÄ
0o
$
ÑÃgÙÚÏ
$
éǜ6.ÃÄ$æQg
4
ÝØp
(
#=g¤K.
$
©‚
92?H2E)$$%E
wš‚g÷
3
ÎD:`@‰Ù°Þ
$
ÒJA=gè
R
$
ö
$)
açÃèklå¼ØpÔ
$f
0o
$
è–øaùÃg“
$
ZÑ|p
)(
wÞɘ‹
OP¿XÃËϋÜ
(
\•ÞäˆÖ)ޔƹœ
[#0o
$
*‹Ö)ÑɘB[#ÙÚ
(
ìÑ
ø\•ÞäˆÖ)Þ
$
ôIÞwÝÛB?ç
[
ò
‚%Üäpf
$
±Ýp`¶·dôç`
(
†î,
˜ÞìÑÃsø
b
=òi
$
¢ËœˆÖ)ÞäôI
Þ$Æ
$
\ˆòÎϋÜ
$
K‹MêhWBžÔ
2B
–‚
$
ºO)*‹¶·¿ÒGHç`
( ?Hb3
;D?
C¯ËÞÖ´¯ËÞ®ø†îÞÖôIޔ
Æ
$
±Ý?
)
ݯËWB[#žÔ–‚
$
CìÑø
†î,˜
$
žÔ–‚ÏÏ
$
®$¯ËÞìÑø®û
)
ޞÔ/ÑÌ(‹Ü
$
JþøˆÖ)Þä\•Þ
Ӯ
$
œÜƒaçÃ
$)
EÑ$
$
èp\ˆAg
îi
(
÷i
$?Hb;D?
WBB/”•
2
#ã¡oî
P¿XI–‚
(
dVdO
ôœå˜“.˜úc
!
ØØéÈt~ÜÝ
$
B
&
»Å˜t~p~ÊÎè˜
$c$$#
6i
$
Ã
䮶ìíŘìÎÏ
$
WBÜäTf
$
|p
4(
‰
p¶·©‚ÑÃgéþϐg
&
»˜Ê–øÌÍ
嘓.˜
(
/()4/
)$5
x

y ö
&$
÷ö
#
|
W-Rc&$$ ;-+# 2VXVYF$ )$5
p
)!

AH83B2
JÃp
LPXc)!?QNAH83B2Y,-SNY_R-F-\NO,Q XS-V_
p
4!
ØØéÈt~p
LPXc4!8O._RNY\O,F-SR-OTP0XXSO_Q
dV%O
ôœå˜“.˜(
!
@P“#ì§/<
ÊX¤Ê~ÎÖ#6OÆ
$
©‚gËÈh>ô:
âæ
)
æBæÓU
$
6£0
5 __.
68
$
º¾›
¤l,ò¹´ø
(5f
øl,ýwIZæÒ°ÃÄ
;F
+$,
ùúÌÍP¿Å˜
(
DE(KØÙ
35$#3
á
)
ÅÊ°
)43
ŸP¥Á
)&3
”èÌèfÁB
)3
”
è
343!&3
Ìè

‚Á
!
6
&3
”èÌèfÁøa
&
»ôœ“.˜
(
dV#O
ۋO$
&
»“.˜DË0_pf
!
#
#K˜ÊœwÝØp$Dˆm
!
¤/b

†mÒ°
$
ª‚øé›;0ÃÄ;F†mÃÄ
$
’;
0¹Cª‚
M3Z

$
’;0rC”ª‚
H8B
h
·
$
ZÑ|ê
(
¢ê

èR
$
ä\•ÑƒÞֈÖ)ÞÎÏ
$
g
&
»˜ÊœôIދO$DˀC
$
®$ÅÊ°
)
43
ŸP¥Á
) &3IAA2
DËWBÜä0o
!Aj
$c$5*
äôIÞÎÏ
$
ØÙ
35$#3
á
)
ÅÊ°Ö
&3IA3
A2
œw¥,ދO$DËÜä%´
!Aj$c$5$
®
43
ŸP¥Áœ
?Hb;D?
C¯ËÞÖ´¯ËދO
$DËÉB\ˆpf
$
v¹3®œMêhуÞ
!!
ê
!&
»“.˜œwÞ$DË
&
»“.˜œwÞ$DË
!
¤/b

0_
?OGRN!<-0FN0F!_NO^ OSNO ,QO0XNY-\\-VSGP-3.OS^NSYP0 NO,Q XS-V_
Þ( ØÙ
35$#3
á ÅÊ°
43
ŸP¥Á
&3
”èÌèfÁ
\•Ñƒ
4# $(c%(( y)$ %%)c&%% $ 5 &((c(% %$
y( 5)(c)%%

5( )5c(4# (
y&) ##5c(%4 4

$ ))$c(() 4
y) $c4(

ˆÖ)у
4( (%5c% 4 y) &54c((& 5 )& )$$c%&$ %
y)# ))c)$%

)( 4&5c&&4 #
y# (&c&%& #

) $4$c %
y)$ ))$c4&4

ôIу
&% &$c#(5 y$ )%c&% ) 4 55c($ 4 y4( 5&&c4$& 4 # (%c5) yc$5Dn$5 4# 4$c)& y%# %$c(( #
Mêhу
)4 5$#c$55 #
y)( %&c&5 5

) #%c(% 4
y) )4c%#

$ 55$c4(4
yc#Dn$5

% 5$c)) ($
y 4)$c%#4 (

?Hb;D?
´¯Ë
(5c$44 $$
y&($c($ %$

()c#% #$
y %c4&# 4

( 4$#c&%) %
y&& 5&5c454 #

4 ($$c(## $$
y) )$c4($

?Hb;D?
$¯Ë
& ((c$$%
y& ($#c$$4 #

)4 ((&c(& (
y4# #5(c)() )

& %&c))5 & yc$5Dn$5 4 $4$c() )
y)4 %$c55) (

?Hb;D?
C¯Ë
4 %$#c%$4 4$
y4 #5c4$# )5

) &)c)) (
y( 4((c&#& 5

#& (5)c ) y45 4(%c#&( & 4 #$c( $
y %)$c54 $%

!!
¤
#
äôIуÞÎÏ

Aj$c$5(
Ö
?Hb;D?
´¯ËދO$¹œÜä0o
!Aj
$c$5(
DZ¢ê

è6¿K
$43
ŸP¥Áä
?Hb3
;D?
¯Ërfìíí¿
$
®®û
4
»“.˜ŠÇð
ñî0_
$
gè@ä®P¿Pñ$67îBí
(

$
i5ZѱÝ
2
#
)5345
HŽ¤N.è@@Pi
ˆgîۋO$ØÙ
35$#3
ᑮÅÊ°
)43
ŸP
¥Á“
&3IAA2
DË®š›çR¥¦
$
®
?Hb;D?
ÑÇWB\ˆ–‚
(
%O
ÿó
ÇYÚH?–‘[»8œlŒ‘’h¹‹6
mîŒ
$
Ã)Š‹6èË_“‚øÅT
֕3Œ
(
®@PN°ägîу°B,˜”
•°P¿˜ÑÎhEãJÌÍ嘓.˜èXO
k§Kgîåê¸üAŒê¸ü‘@0_“,˜
”•/§
+,
$
éÇ嘓.˜è–ø
2B
m|ùú
ÅT
+),
“,˜žÔ€ùZÇ
(
p„…6¶·
ۋO$ÌÍîP¿˜ø89“
$
•E@¸¹C
º»¼ôœ”•‘’
(
ZÑÜÝ
$
äôIÞÎÏ
$
?Hb;D?
ÞۋO$ØÙ
35$#3
á
)
ÅÊ°
)43
Ÿ
P¥Á
)&3IAA2&
»P¿˜lå‹Ü0_
(
/$()4/
Èôi.
#
@¸¹Cº»¼1½¾‹OP¿Þ„…
p„…l·
&
»ÌÍî嘓.˜è@ä
?Hb;D?
–‚‘’Bí
(
®$ØÙ
35$#3
áÖ
&3
IAA2
œ7ÁP¿–—$B€ù–‚
$
)‘8ê„
.dnq¿Ò`@€ù“
(
¶7Á@P¶7Á
”_6
!?I
ÖL&S7èÁwm6
!22B<
–‚
åç„.d
$
„.dq
)
ý«_–—Åå„.d
3
@3
á
$
.4¢q¹èL€R
)
«_PñDEåçØ
Ù
35$#3
á
+4,
$
®p„…$ôIސØÙ
35$#3
áD
ˋÜCøw¥,Þ
$
gIÇ+š›„.dDË%
´
+&,
$

2B
N4„.d¿Ò`@‚%
)
²¥ì

+53#,
(
Ç®
$
B됑
&3IAA2
œôIÞÛ
‹O$DË)‹Ü€C
( &3IAA2
‘Ì7Á
P¿$ÆŘ
$
®ÿîqÌ7Á”_6”_ç¶

$
®¶7Á¢q¶7Á7苶6–‚ç
&3
IAA2(
p„…$ôIސØÙ
35$#3
áÖ
&3IAA2
DËkÜä€C
$
±Ýè@þøÌ7ÁÖ¶7
ÁP¿oî
(
ː„…0qK¶ÅÊ°
!,-SFPY-R
ii€
ä
2B
B?:2d¿
+%3(,
$
ÅÊ°¡fi¹sr
žýpf
$
®Ãœ#xö°$ØîÅÊ°i
?·òÕCøÙî
+)$,
(
ÉÇÅÊ°œ
2B
ΐ0
_W°–‚G¹œìí
$
C®Ü䞟ib
ª®çøÅT
2B
€ù“.˜”[
+),
(
ÅÊ°
–øŠÅʚ›
!C<
€ùÞççÃ
$
®Ã¦²‚
íC
3
§°
3
i¦ò
!IA2
ˆ
$

$
¡O$PC

C<
èfkîp’
IA2

(
Œêýw‚
$
°8
C<
çèBCi¸ü¹s¤¡
IA2
fkîàá
$
®ÃèJ›£¤
2
#Þ3°34
)?OV
1•oî4Á
_æ”
+))3)&,
$
†®¤¡\ÆçRàá
+)5,
$
l‡ø
2B(
p„…$ôIÞÛÅÊ°DËÜäCø¥
,ÞÖуÞ
$

2B
N4ÏCÅÊ°iì
×æ
(
°8Ci
C<
è@PŠo喗“b†
+ÑÃZš›¡ŠDË%´
)
¡O¢Ë+ÑÁ“
’DˀC
$
14þçno›G1
$
¤¡ŠP¿à
á
+)#3),
(
®
?Hb;D?
wÞÅÊ°DˋÜ%´”

?Hb;D?
@Àp’°8ÅÊ°oî€C
$
±
Ý
?Hb;D?
@B/};oîÅʰё°Œê¥
¦“ŠP¿àá
(
43
ŸP¥Á‘ËŸ7ÁVM$P¿Eؔ
[
$
˟7Áq[¿å_–—åç
43
ŸPf
Á
$
r¢q¥Áw6
!HBI
B_þç
43
ŸP¥
Á
+)(,
I¢CRK°8
(
éÇrè–ø˟7Á
P¿“
HBI
êëo.˜
(
p„…$
$
ôIÞ
43
ŸP¥ÁDËÜäžæ
$
Cv•hEK
43
ŸP
fÁÖ˟7Áoî0_
$
±Ýè@
HBI
6¿o
îêëM¤
43
ŸP¥Áœ‹O$DˀC
(
HBI
‘[»ŠšZ6
$
r7ɞç¹sš›@Ë
L‚Õ‚%
$
G¤¡Ò€@nqmÊeæç²
x
+4$34,
(
p„…$
$?Hb;D?
wދO$DËÜä

$

?Hb;D?
@ÀB/p’
HBI
oîêëã
¡
43
ŸP¥ÁDˀC
$
±Ý®è¡:oî
HBI
êëI±C@ËL‚Õ
(
@PÑ£œ¥¦
?Hb;D?&5 T

2
#
)5345
HŽ@
ˤN½¾ôIې‹OP¿˜0_ÎÏl·
¥,.ۋOP¿X?B0_
$

?Hb;D?4
Ý·òÙòÑ®0_)B㹺
$
®$
?Hb;D?
´
¯ËÞÑi5
&
»P¿˜\ˆ–‚ìÑÏç
(
g
&
»P¿˜Dː0_Ã(kl¥,¨.½¾ôI
ɘ°8„.d¿Ò
)
ŠÅʚ›“ŠP¿Pñ
}0
$
*‹½¾þçè@äg
4
ÝPñBí
(
p
„…Zѹsê‹
2
#
)5345
HŽ@ˤNaùš›
„.d¿Ò
)
ŠÅʚ›ÖŠP¿`@ç认¡
ɘçR‚%
$
®ÃÝ
?Hb;D?
è@aù@Pˆ
„.d¿Ò
)
ŠÅʚ›“ŠP¿–—};
2
#
)5345
HŽ@ˤN½¾ôIÛ|sÊ`@
$
Gø.¿„…
?Hb;D?
W°
%
Ǭ
&
‘’±=
ŒN
(

vw?x
#
+ ,!HNN8$ bV C$ UO6?>$NFORc@__-YP0XN\N,FY-\.N.GSO0N3O03
,Q-SNT 92AM_OFQ*O6+U,cU;NVS-Y,P$)$&$4&!4%#)54c
+ ) ,!8O0/O6Z$ AP._RP^OSc>NOYYNYYP0XFQNO.6R-PT ,OY,OTNQ6_-FQN3
YPY-\2R]QNP.NSoYTPYNOYN+U,c:0FUEP-,QN.!## )#c
+ 4 ,!H9PRV,,P$ HCQN]]P$ CENS0OSTP0P$NFORc<-0\-S.OFP-0YO0T GP3
-R-XP,ORO,FPdPFPNY-\O.6R-PT GNFO_N_FPTN)5345+U,cAN_F8,P$ )$$$!#5&c
+ & ,!HP.q0 :B$ B~O]2$ 9N0TPNFOH$NFORc2.6R-PT3GNFO!)5345
P._OPSY.N.-S6O0T P0,SNOYNY;@P0 FQNFN._-SOR,-SFN7-\SOFY
+U,c;NVS-Y,P>NY$ )$$( $#4!)#)(c
+ 5 ,!8FN_O0P,QNd9[$9-PYNNdO[Wc8FVTPNY-\FQNN\N,FY-\\SOX.N0F
!)5345 -\GNFOO.36R-PT _N_FPTN-0 FQNGNQOdP-S-\SOFYP0 OSO3
TPOR.O]N+U,c;NVS-Y,PENQOdAQ6YP-R$(($)!5#5#&c
+ # ,!8FN_O0P,QNd9[$ 9-PYNNdO[W$ HO]OSNdO;2$NFORc8P0XRNP03
FSO,NSNGS-dN0FSP,VROSOT.P0PYFSOFP-0 -\O.6R-PT3GNFO!)5345 _N_3
FPTNP0TV,NYP._OPS.N0FP0 YQ-SF3FNS.SOFQNSFQO0 R-0X3FNS..N.3
-S6P0 SOFY+U,cESOP0 >NYEVR$)$$4$#!)#(%c
/()4/
)$5
x

y ö
&$
÷ö
#
|
W-Rc&$$ ;-+# 2VXVYF$ )$5
+ % ,!

$

$
,ïæ
$
.
c
@¸¹Cº»¼Ñ
2
# HŽ¤N
½¾Û
FOV
1•4Á_í:ˆ‰1•
Ö
C8M34
ê
ëÙÚ
+U,c
fK,-.
$)$4$)! )#&$c
+ ,!
,ïæ
$

$
¥õ
$
.
c
@¸¹Cº»¼Ñ
2B
Û|s
ÊÖHŽno›%Z6êëÙÚ
+U,c
$%$,-.
$
)$4$4!4%#)#4c
+ ( ,!ARVY^OR?$ ROS\SO.N*-S^ \-S_S-,NYYP0X$ dPYVORP]P0X$ O0T O0OR6]P0X.OYY
Y_N,FS-.NFS63GOYNT .-RN,VROS_S-\PRNTOFO+U,cE9P,Y$)$$$#4(5c
+$,!
¼l¤
$

$
¢Hç
$
.
c
KI>l’¥,ۋOÎÏP
¿Þ„…
+U,c
$%$,-.
$)$&$4(!%#)(4c
+,!2F^P0Y-0Y2U$ <-RGVS0 Z2$ BNCSVF-ROWC$ NFORcEP-.OS^3
NSYO0T YVS-XOFNN0T_-P0FY# _SN\NSNT TN\P0PFP-0YO0T ,-0,N_FVOR
\SO.N*-S^cEP-.OS^NSTN\P0PFP-0 *-S^P0XXS-V_+U,c.O,-R$ )$$$ #(# (c
+),!8,Q0NPTNSA$ IO._NRI$ EVNSXNSMcEP-R-XP,OR.OS^NS,O0TP3
TOFNY-\2R]QNP.NSoYTPYNOYNP0 GR--T$ _ROY.O$ O0T YNSV.+U,c
<;8 ;NVS-Y,P?QNS$ )$$($ 5!&# 45c
+4,!8NXVSO32XVPROSU$ AOSPY:$ 9V-]A$NFORcAS-FN,FPdNO0T F-7P,
S-RNY-\T-_O.P0NP0 AOS^P0Y-0oYTPYNOYN+U,cU;NVS-,QN.$)$&$
)(!##(c
+&,!9V0-]39V0-]UH$ COS,~O39-RP0OL$ WOSq0 >$ NFORcCN0NSOFP-0
-\Q6TS-XN0 _NS-7PTNP0 FQN.NRO0P0 GP-Y60FQNYPY_OFQ*O6
+U,cEP-,QP.EP-_Q6Y2,FO$)$$($%(&!%#$%c
+5,!EOSPRPAO-R-$ BNFPdPF6F-OXNP0X-\RP.GP,T-_O.P0NSXP,Y6YFN.# OSNdPN*+U,c
9N,Q 2XNP0XBNd$(($$# !=)# 5%c
+#,! MN.__OP0N0 ;$ >V-FP0N0 I$ ;OXSN0 M$ NFORcAD?YQ-*YFQOF
YFSPOFORT-_O.P0NB O0T B) SN,N_F-SYOSNTP\NSN0FR6O\N,FNT P0
2B+U,c;NVS-R-X6$ )$$$$55 !)# )$5 c
+%,!BOdPYMH$BOdPYE9$CSNN0*ORT E8$NFORc<-SFPY-RO0T 2R]QNP3
.NSoYTPYNOYN$ :# GOYORYFVTPNY+U,c2.UAY6,QPOFS6$(#$&4
!4#4$$c
+,!_S-XSNYYP-0 -\TN.N0FPOP0 YVG/N,FY*PFQ 2R]QNP.NS3F6_NTN.N0FPO
+U,c2.UAY6,QPOFS6$)$$#$#4!)#)#&c
+(,!IVO0XRNdNR_SNTP,FYR-*NSQP__-,O._ORd-RV.NO0T ,-X0PFPdNTN,RP0NP0
2R]QNP.NSoYTPYNOYN+U,cU+)$,!HOVXQRP0 C2$ EOSNF3<-00-SDc8N7VORTP.-S_QPY.P0 FQNP0\RV3
N0,N-\OTdO0,NT OXP0X-0 OTSN0ORQ-S.-0NRNdNRY# FQN>O0,Q-
ENS0OST-8FVT6+U,cU45#c
+),!B-N,^NUB$ HO*Y8 9$ LOV7;C$NFORcER--T3GOYNT _S-FNP0 GP3
-.OS^NSY\-STPOX0-YPY-\2R]QNP.NSTPYNOYN+U,c2S,Q ;NVS-R$
)$)$#(!$#4c
+)),!,-SFN7OYO^ N6FOSXNF-\FQN.OROTO_FPdNSNY_-0YNF-YFSNYY+U,cU
;NVS-Y,P$)$$%$)%!#)%c
+)4,!CSNN0 M;$ EPRP0XYH9$ >--]N0TOORE$ NFORcCRV,-,-SFP,-PTY
P0,SNOYNO.6R-PT3EO0T FOV _OFQ-R-X6P0 O.-VYN.-TNR-\2R]QNP3
.NSoYTPYNOYN+U,cU;NVS-Y,P$)$$#$)#!45#($&%+
+)&,!8-FPS-_-VR-Y:$ PNTN.O00 ?$ NFORcCRV,-,-SFP,-PTY
FSPXXNS2R]QNP.NSTPYNOYN3RP^N_OFQ-GP-,QN.PYFS6P0 SOF0NVS-0OR
,NRYN7_SNYYP0XQV.O0 FOV+U,cU;NVS-,QN.$)$$$$% !)#
45+
+)5,!Z-S^.O0 UH$ N7_-YVSNSNTV,NYO,FPdOFP-0 -\P..OFVSN0NVS-0YP0 FQNdN0FSOR
QP__-,O._VYP0 SNY_-0YNF-Y_OFPORO0T 0-0Y_OFPOR.N.-S6
+U,cIP__-,O._VY$)$5$)5!4#4)(c
+)#,!UO.PNY-0 A9$;6PSN0TO9U$ZOR^NSE>$NFORc:0FNSO,FP-0YGN3
F*NN0 -NYFSOTP-RO0T XRV,-,-SFPN-PT SNXVROFOS6N\N,FY-0 RPdNS3Y_N3
,P\P,XRV,-,-SFPN-PT3P0TV,PGRNXN0NY$ _-YYPGRNNdPTN0,N\-SOS-OR
-\QN_OFP,GNFOQ6TS-76YFNS-PT TNQ6TS-XN0OYNF6_N+U,cUD0T-,SP3
0-R$ ((($R#$# $4c
+)%,!>V]]P0 U$ZOX.O0 28$UN0YN0 UcCRV,-,-SFP,-PT3P0TV,NT P0YVRP0
SNYPYFO0,NP0 Y^NRNFOR.VY,RNY#TN\N,FYP0 P0YVRP0 YPX0ORP0XO0T FQN
N\N,FY-\OYNRN,FPdNXR6,-XN0 Y60FQOYN^P0OYN34 P0QPGPF-S+U,cBP3
OGNF-R-XPO$)$$5$&!$#)(c
+),!CNS.O0 UA$ ZPYYNEH$ ?QORNSUA$ NFORcHN_FP0 TN\P,PN0,6
,OVYNYP0YVRP0 SNYPYFO0,NP0TV,NT G6V0,-0FS-RNT TPOGNFNY+U,c
BPOGNFNY$)$$$5(!%##)#c
+)(,!<-YFO$9OSO$AN0YO$NFORcASN_OSOFP-0 -\43.NS,O_F-RO,FP,O,PT
O0T 73O.P0-NFQ6R.NS,O_F-RO,FP,O,PT+U,cASN_ EP-,QN.$()$
)!5#&%c
+4$,!
,?¡
c
C ¡c™Š
=
C@ËP¿àáänqmîŒ
+U,c
$%,ê@j
$)$$$$#!4#)&c
+4,!
=Èñ
$
_òé
c
ÇYÚH?ŒÒ€@,˜žÔ
+U,c
$%
ð,-.
$)$$$$!##&5c

yz-0
!
‚ƒ„
#
/)()4/