免费文献传递   相关文献

Overview in establishing animal models against ischemic cerebrocardiac disease and thinking about efficacy evaluation of traditional Chinese medicine

缺血性脑血管病动物模型研究概况与中药药效学评价思考



全 文 :#{~€
#
…Q›pQûÐÊÌü⃄¢´i
rÇÇé]ýþÿ‘
ÝÞ
P
!
#
E»ó
W
!Ph
&ã78HKLMJ
#
&㠆©
WLMMP^% Wh
&ã8HKA¯
#
&㠆©
WLMOLL
$
†;
%!
ê>$„…Q›pQûÐ[Ð¥ÝÜ
#
Ç̈´
#
Çéýþ
#
Ñ҅¿7!
vhst>Ž™ü[±¨p…Qx
Ð[§¨ÊÌüâ

ûÊê)rÇl—[¯-´µÄÁ[ÊÌüâ
!
8Éz´Ç̈´ÑÇéýþ
!
>Vp…QÊÌüâ[
ƒ„iéêxЃ„/3Q0ij;
!
AÆÊÌüâ[zԛÑ*+›
!
AéêhrÇÇ¥ƒ„iÇéýþ[èéÇÌ
!
]éê_w&ì>[Òé
!
µo…”]AÆÑèé[rÇˊÇ̈´iƒýþ[ƒ„Nw

$
Ž
%!
…Q›pQûÐ
&
Çéýþ
&
ÊÌüâ
$
8$f
%!WMPPMOMPMPM
$
‘’Eq
%!
­æ
)
iuŠÇËÜ
*
ö÷iu«u
$WMM_d+M_LMW;
MPL%&
YúRiuŠÇËܚěu¹uuv
$WMM_d+M_OMP;MPO%&
Y
úRDE¾ËŠuv
$WMMNMPMMW%
$
“„>”
%!
!
45
!
ƒ„$
!
³Eã·Â
!@(&.$MLOP% NW_^_N^O!
-;I$&.04)%/)*PM[\PXOhG/I
!!
pQûÐM2i¸Æ±¨æç[NŸÐљÐ
!
ªr
…Q›[Ћ~pQûÐ[
[Lg!
”÷;Æè_3ù
Â
P(
!
ª‚&Ð@êpÊwÉ\‡È@·A[pÊwûòt
s
!
Q&eJOå‰
!
pØQž¦*W*
!
pÙwaÛf
ã[|FJùë
!
Qû~QA|Ú
#

#
Qûts·A[
pÊwå‰M…Q›pñr[‚&È@

…Q“³pÖË
¨©ÛÜÑÔ½[E›Ýܙƒ
#

!
ÀхQ›pQû
xÐMvh±¨;o×&Q¼[Ï];D
!
]½¯°rÏÇ
f>Y*¹Ò[UŠE›

ê>ì>Q—æp…Q[s©§¨Ñéꃄ
!
±º´
µº
#
»
#
 
#
^
#
@x¨
#
uv
#
6v[™ ÊÌst>¿w
¯-[™ p…Qüâ
!
6Fü[>YZ[éêÐ¥¡.

A§¨ÊÌ[´µ
!
”÷;`õiÒ´›¼½¨ÊÌ
$

uvÑzSvê‚
%
@ªpQûQa
#
+~¦*”N±
&
4
8ɧ¨ÑÑ
&
èFJ[ã¥
#
Ç¥
#
ã\…T[§¨™Â*
o•–6‹

ê)…Q.‚&wxOp…QÑ2Øp…
QÊÌüâ
!
vhrÏÇRô\ƒ„rAp…QÊÌüâ
ÜÝ
!
s¤_¾ÕJ¬›RôÏ]‰p…QxЧ¨ÊÌ
üâ
!
stÐÆ0ÄÊÌüâMrÏp…QÊÌüâ[æ
…†
!
1sÁTrÇÇ¥ƒ„iÇéýþ[…Q›pQû
ÐÊÌüâ
!
Y(û|ABrÇÇé0•[*+›izÔ
›
!
fˆ´irNJÇÇéýþìMwè¼Ô›@Ø

ê½
!
¤7
AN›[Áü…”G]rÇÇéýþr[E›8É9ï
!
>

#
•–ª¬¿iÁ››

!
NŸp…QÊÌüâ
!]!
Op…Qüâ
Op…QüâMpQ&5PQ”7OV¾9Ó§
R[pQ&֖?
!
·A”uØ6hpŒŽÛÆ
!
pÇQ&
jAA-
!
AÆÊÌèl‚ÂG
!
uuµ—>ŒY‹

ÜE
…”‚&è
^
 

!]!]!
–Qû叔
!
x
84&0)(&
Ñ
7%(%&(A
‡
W(
pØs
t
!
m¡å[)½5ÊwÑðÊw“³Op…Q

N›Ê
Ìêuv
!
wèAup2i…Q[ij›—
#
*m¡½Êw
.—3Ä܅Qi֖7š
!
8f§RYZ.[p…QÛ
܇¯-

y#í‡
O(
´›+~®ÌmݕÀe[æ Á
ü
!
(ê(å
^
êQû
!
;kbO›p…Q
!
a_tQ
ZM*Šu#Qe…Q•pQ&·
!
½ü⃄ƒÈ
¡¤AO›p…QÛÜj@é\[AB

÷üâ]|.
i&[ã¥ôhƒ„†ªMp…Q§¨ƒ„…Tèi6k
[›´
O(
!
*›Aڛp…Q֖&ÛÜÝÜ[ƒ„ÑA
pj@Ú[$†

ìxðÊwiÁ1hÊwšèÌm
Ý
!
><ÊÌYZ KÑYZþgšCE–u
!
üâ[Ú
ދ–·
!
zԛ»–C
!
÷üâ(›¯°¯°[ƒ„

!]!]#
zSvüêQû3‰”Op…Qüâ
!B(D()(
‡
^(
RzSv…0ž[
a&0
*
!
@f0eH)
=
ÓÁÚ
.up…Q

7-
.
ÜE¡.yH
!
ËÜ6
!
*ÁÚOp…
Q
!
Úދ—
!
Å6k›AÚ›ÖË8Ô
$5(&$A(5 )(4;
%/)$&5($2#!R>R%
[ƒ„G›AŠ[ÖËAƒÛˆ1

›
ªÜE[
R>R
üâwèÚ›
#
ZM›
#
H|›
#
Á››‡
¯-
!
Aéêp…QÖË8ÛÜãÝÜ[ƒ„G$†b…
QÇÌ[ÇéGÇ¥]ÝÜèû|[!·E›
L(

…-
.
]
/__WW/
{
OX
ï{
PX
•
WMPP
÷
N
²
!!!!!! ! ! ! ! ! !!!! ! ! ! !
S/&hOX! :004(!PX
=4*402! WMPP
)éQû|ÚѾÌmÊw[K_èDE
!
Íäã
R>R
[0•YzÔ
&
þU¡6Íã¥!ÀK%–ê:;
&
ãE÷
Ñ&—

!]!]$
üêQûåGþ¦*·QM”
!1I2#
‡
X(

å[)½5Êw
!
>0ÄÊwtQJZMǃٻ¼™6
c‡ÁÚ·QM
!
*ÍpQ&·Z·0»N[
Lg lPLg
7-
.
ÑÑyH
!
|MÚ
!
衋·
!
g±êÄÜÊÌÂG
!
äã[!Mhp…Q
!
ApÇ,AB
!
4stp[֖?
&
Ú
›•Ô½‹·
!
¿vKRpÓÔ2Û`–|A

…-
.
N@
Œ])é¦*fÁڅQYO
!
<ªpà˜[QoG§¨0•
!
Yg›óoÊÌ
!
,”8
ÉÖËÉêùú
!
YgAåQû¾Ó‚“³[ÊÌÉê¾
D8Éùú

÷üâü[>éê_Â:
#
ßÞgYO
#
pQ
û2itsJå‰Ä>Qž·–?“³[p¦*W*ÁÚ
YZ.[pÙw…QÛÜ
!
A$†…Q›pÛÜ[ÐÝ
Ü
!
ýþbp…QÇÌ[Òéìèþ_

!]!]%
ƒÊw叔
!C$I(*$I$
‡m¡.ÿs;Êw
#
Z7.3=)½5Êw[…”jÜOp…Qüâ
!
x÷…
”Y(å>poQ‚ÇQû
!
f<`å>±ÁhÊw;
[)ÝQû
!
ih£–Qûåü╖
!
p…QÚދ—
<,×ֈ´Mª‚&7-

…-
.
ÑÑ;uwùc2i
!
]ÿjQ&7äaAB

÷üâÏ6k›p
…Q[ÇÌG…”[ƒ„
!
Å(êM0AêV¸¥Ã[Op
…Q֖&[ÊÌüâ

Op…Qüâ*årÖËFãQo
!
…Q7#/
o
!
*›ƒ„»¼YZ7š[…QÙw²ã[¿ ¾
D
!
‰.Ö˨©âa›GAB@—i&¥,
!
ìAÊÌÛ
ܛ–u
!
Ô½‹–—
!
¨Nß§È,¾[ë´
!
iéêpñr¡.jCvõ

!]#
23›p…Qüâ
23›p…QÓËôØJD—+0eM;Jî0u
prÊw
$<=%
23›p…Qüâ–|”±¨pñr
Ð7[éê©´
!
4ÄÜ2Ø;q
!
O—AB6
!
‹—
#
üâzÔG*Eø›•§¨‡7-
[(

@è)ݦ
*
!
a?pÙw…Q.Y|
!
m¡ýþbp…QÇÌAƒ
®òª
#
¾nòÛ(G6rß([ÒéiÝÜ
!
êñrÑ
Òµo¥,¦)

A23›p…Qüâ[ÜÝ
!
vh•–
N›[è—+”
#
Ån”
#
I\]¶·”ÑA‰”‡

!]#]!
—+”
!J/%b(0
p5\›+§—ý”ƒ„pQû
!
ê—t}+§—ý”
!
@,”ÄÜ+~MN
!
4“³pÄ

—+”
<=T
üâ…Qé•*+
!
MÅA\›¸6k[ËÒ
23›p…Qüâ

7-
.
÷”]ûÒªãE
!
ÓÔÚދ
—
!
…Qé•>Á›p…Q¾x•ÖËÞg…Û[çjG
}ÐÑÒóô[ƒ„
&
…-
.
—+ËÜu
!
pÁž®,
!

¥
!
¾D>pX*×
!
ÑÑ;–uÑ
<=
3‰¾,”ùú
֖?ÛÜé!
<×&–—[®öÑÑ÷J
!
#Ü>ªÇ
6\›

!]#]#
Ån”Qû~An叔ÜÝ
!
uvuprÊwå
‰¶·[p…Qüâ
!
Mƒ„23›p…Q¸N›[§¨…
”
C/`4I
p51#
!
”÷;Y&bn

÷üâü[
>±¨¬Ÿ›GP7›2Á›p…Q[¿ ë´
!
,ח
+
!
ËÜ6
!
ÜE[üâÐD|A
#
ij›>
!
|Ú[pÓÔ
2Ûu6[CE–6
!
<…QØIgÔ
!
>gb+/Ä܅
Q
;
֖?7š
!
†ªÁ›s;ÿ…Q֖?[Ð¥ã¥
ÝÜ[ƒ„ÑÇÌÑÒé•iÝÜ[ùú

½®
!
An3‰
<=
¾Y“³QM
#
QdÑþ®[END!
YAB…Q¾
pmmÑ+~MÐ¥D\[lé¡.‡
!
<¹è@+~ãE
ApÛÜf~Æ0•
!
7—+3‰
<=
”st[23›
p…Qüâ

Á›Çé[ýþGp…Q
;
֖?™…T[
ƒ„
!
MvhÜE23›p…Qüâ[¥Ã…”

!]#]$
A‰”
!C45/
‡p51#>\›lþQA?ÐpÊ
w|ÚpA‰[uvüâ

ꃄ§¨›ñrbQAÑÒ
é•
!R(&d//U
‡
N(
st>ÇÇڛpQA|Úüâ
!
V|
*ê¤[)\ÈadWÔËDÐ+ÉÐb
<=
(
!

Ÿë*ýëþ
$B1=%
õ2
!
§ñdWå
<=
Q&

7-
.
ËÜ6
&
üâŒY‹—
!
ÓÔØI[Y*Èí›
.
÷Ñڎ
&
]Hl[…Qëìª
!
Qp¨W[€ÅÇ%㝅Q¾
[(67
!


‰[XQûòÛ|Ú¢\›áQë´
!
0•*·ApÙwÓ
‚ãpmm

…-
.
xA[9ݛ
!
,”È%A‰[
ØIiu6
!
pÙw…QY|
!
Y¬ÖËùëÑpÙwÔ
·6‹

÷üâÁ›ÅÆ¿tÈÄYFãQAé\[ƒ
„ѝAÑÒ[ùú
!
†ªM±QîvA‰Fìè͛
þ_

!]#]%
I\]¶·”
!
|Ÿ´›
a02$%
uv
!
VuvùÔ
]ÔIß_
!
‡È+§
!
qw?xIIÁÂå¬@Ü
!
JHq
w?xIIÁÂ8I—
!
›¯Ô—I¬
$LMM lXMM )I%
“x

!
In¿¡+§iQû~[IIÌY|+
!
kÄI]¢!
“³“xØIR4Qû~R¨©R›pmm
!

ApÓÔ

ꃄQA|ڛ2Øp…QÐÝÜG§¨
ÑÒ[*ɛ
!
>tó‡
_(

)
ɾµ“Fã
*
GI\]
¢\äãHnìc
!
_fÛÜQû~R¨©
!
ÄQ6VÄ
®f|ÚQA[È¥
!
¶·jÜp…Qüâ

7-
.
üâÜ
EyH
!
6L
!
ij›>
!
5•~*Ú–™ƒ¤[ƒ„
&
j
A1ZЛ
!
¸¹>AQûÑpÙw[ÝʛãE
&
Ê̌
Y7šx
!
*›Ú
#
ø›p…Q§¨ƒ„
&
ÑÑËÜ6
!
Q
A|Ú¡.i±¨jN
&
“xª
#
ØI
#
u6G.4Ä
Ü
!
*›ƒ„pQA¾Ýg
#
ôhG|ì01¾DÑýþ
ÇÌÒé

…-
.
XQûÛÆÑQp¨W—t=
!
i±¨N
Ÿ[…Q›ñrŒ]CE
&
xÓ‰3u6Ñ(·[™D
!
÷;AÇÌÑÒEKýÔ
!
,”jÜ֖?ÛÜüâ

vh
!
p…QÊÌüâ[ƒ„]Ü݅”
!
§¨;qÄ
/MMOW/
{
OX
ï{
PX
•
WMPP
÷
N
²
!!!!!! ! ! ! ! ! !!!! ! ! ! !
S/&hOX! :004(!PX
=4*402! WMPP
܇…TÏ#&>÷u8æ
!
¿ …”Œè7…-
!
ƒ„F
\ê)§¨v[у„…†´µÄÁ[üâ

±¨…Q›
pñréê¼R
#
Ð@ÑQaIœD\™2
!
\›*ÄÜ[
ÊÌüâ*»/6‹ª™ƒ›
!
2Å[ÙwÐ¥
#
ã\Ñã
¥ùú×&ZЛÑÑû|w#pÙw
&
…Q›ÛܸLU
450U65~ã[¾D!g]Ȩ̂¨r8Ƀ„
&
þ
®ÙworJÖË8
Z
ÖËaYõP¨©…0wûFã
!
Y
g8ɅQ7ßëèN[–&ƒ„
PM(

²þ~ã¥ëì

#
*jÜ[ÊÌüâAp…QÐ¥ã¥ÝÜGÀÑ[ƒ
„M‘V[

#
ÁTrÇÇ¥ƒ„iÇéýþ[p…QÊÌüâÿ‘
vh
!
rÏ]ÜEp…QÊÌüâGrÇbp…QŠÇ
Çéýþ[ÊÌüâu™M¾ÕJ¬›RôÏ][p…Q
xЅT[§¨ÊÌüâ

N›[ÊÌüâèOp…Qü
âÑ2Øp…QÊÌüâ
!
`#&>|FJƒ„8æ



)
¥
;
”
;
…
;
Ç
*
|A›
!
rÏÑÒMËÆiäÐj0Ä
[
!
ÐMç˜[
!
ÆMxÐ]YZ[ô þšÄùë
ÑþX[|¨Æz¼R
&
rÇÒéÓwxÑÐÑÑÆ[šÄ
é!
xrÏËÆ=„ËùiXùj0Ä
!
²
!
]rÏÇ
ÑÒ¡.rÓ*fžþ¨ÿE›`*fº¯[:-é

s½
!
ÁTrÇbp…Q[Ç¥]ƒ„iÇéýþ
þF[1sÿ+
!
\M
)
#&´µxÐ!À`&´µÆz!
À
!
Æ&?išÄ¨¥
#
ÝÜ!ÀÑÁT[rÏÐÆ0ÄÊ
Ìüâ_[Çé¨ÆiÖýþ
*!
—Y(‰7brÇ
)
Þé
*
i
)
Ç¥E›
*
[|A›
!
f<‰7brÇéêh
)
Çéý
þ
*
iéê
)
ÇÌÒé
*
[|A›
PP(

…Q›pQûÐrσ„[¸uW*M…0*jÜ[
p…Qüâ

š²‡
PW(
8Ép…Q
Z
֖?ÛÜ[ƒ„¡
.r6FjܽÊw6&üâ
!WST!OST!^ST
üâ
!

OST
üâwè…QO
#
֖&ïL
#
Aԋ·[7-

½
Êw6&üâ…QLR”

Á›åڛ
#
ø›Op…
Q
Z
֖?ÛÜ[ƒ„
OST
üâ…QL6
!
Á›Ú›
Op…Q
Z
֖?ÛÜ[ƒ„

rÏ[…Q›pQûÐK
ri[2ä
!
Ð@ÑÐÝÜMxdQ¾r
!
äãiUF
â
!
·Apw—åJQ!pw®Ð

…Q›pQûÐi™
 @—j‰
!
<èéêЩÌDYZ
!
\AÐ@ÐÝ¿èª
äÆ,ѯ{

²
!
‘VpØaªAp…QüâÑÁü…
”]ƒ„
!
]üâÊ̗_.{…Q›pQûÐ[ÌDÓ
ë

9i§¨ÊÌö][Yæ
!
Vstì/ÄéêÐ
ÝÜ
#
¡.
!
ìèé
#
ì˕
#
ij‹—[üâ
!
±fÇʅQ
›pQûÐÐÝÜGèéÀÑ[ƒ„

rÇÑÒp…QfióuE›
!
xrÇj…\]Ú
6j£
!
ŽªÇéÌYs©
!
ÉÊ[ö]~RGE›ÝÜ
_Œ]÷™:;
!
ñ<‡
PO(
›nA”stuvp…QÖ
–?üâ
!

@@
¥{
#
ÖËÞg1C”
#
Ð¥ XÙwù
úšÄýþ<=¤
#
ý¤GªÉÊÑÒp…Quv[Þé

!
R<=¤iý¤ÉÊwèÖËpAƒE›
!
ªÞ
é7H|Ù6ÑÒÙÑ¢Q¹ÑÒÙ


!
՝rÇ
™Ú6
#
™:-
#
™´µ
!
!
A‰£rÏ]ƒ„
[p…Q›xÐYZ[Ð@ÐÝ
!
¥”…Ç[¯E›Ñ$†
ÐƤY‡…T
!
H|Op…Qüâ
#
2Øp…Qüâ÷;
Wxj£™D[÷ÐÆz
!
Yg±rÏ¥,…T®‰£Ð@
GÐÝ
!
_f,”þRrÏA¤ÐÆ[¤Y


!
\]²
´rÇj…[¿HŒÇ\]ÑÇ¥]ƒ„8æs©_
!

rÇ[ǛiÞé
!
ŽrÇj…iÐÆj‰[™†›
#
™
ƒ›
#
™:-[ÇéE›‰
#
E›¯-
#
E›ÝÜ
!
rÏÑ
RôÏ]¥,j0Äê!·
!
m¡ÐÆFãsüÑÞéý
þ
!
՛!ãÑRôƒ„Ñ 
!
6F
)
\ARôrÏ[Ð
#
!
ãrÏ[Æ
!
\ArÏ[2ØÑÒižþ›¨ÿÑsÐÆ
iãÌþþ÷gëì[—ã|
*
[rÇE›ü}ѯ
-
!
UŠ1srÇj…ŠÇ
)
xÐÒéýþ
#
rÏÆzýþ
#
šÄ¨¥!À
#
E›ÝÜ$†
#
ÐÆüâ¨Æ
*
[šÄƒ„
ü}

š_²£
!
Rè[ÊÌüâuYg÷>¢„éê§1ù
ë
!
üâiÐÆ[Y±É
&
™(üâ:-H|
!
irǙÚ
6
#
™:-
#
™m+¥,Yé|A
&
rÇ[hÖ¥äÌAü
âè|Ô2#›


!
¾ÕRôÏ][p…QÊÌüâ
!
\ê)rÇl—[¯-
!
0ÄÐ@ÐÝ
!
stgþRrÏä
Æ,Ñ[¯-ÑþRRôÏ]pQûÐ¥,j0Ä[ÐÆ
0ÄȨ̂¨üâ
!
UŠ1srÇj…ŠÇÇéýþ[šÄ
ƒ„ü}ÑýþþF

$
•ƒ–—
%
P (!@#(*&/b$&b4%5() /650($0(-7ZTB(Fa.T! P__XF#2U.ZZ
EEEFE#/F)2Z2%$5(Z*&/00$%AZ02/%A/OXPZ()Z)5(KF#2I&F
W (! 84&0)(&a=!7%(%&(A97h=)(EI/5(&/6b&$2(%$&#(I0U#(%;
G0G#(I$) 2#(4)$)(02#(2`(5 %$29(h12%/V(!P_[_!PM$O%.
WXh
O (!
y#í
!
tÍ
!
‡Às
h
ƒÈ5¡¤AO›p…QÛÜj
@é\[§¨ƒ„
9(h
rÎHŸ]£¤
!P__O!PO$^%.WXPh
^ (!B(D()01! 8$A$) .h-6(G20/60G#(I$$)5 /2#(%U%/G(54%(0/)
2#(b%$) $)5 %(2)$/62#(*(%b&$8,/0<3,4+3:+0*+-.!+4% 9(F
-KU >(4%/&! P_XX! PX. WLLh
L (!
n“”
!
“aç
h
vڛp…Q[§¨ƒ„8æ
9(h
­®Ï
]
/
ÖËÐ]ÖË®ö6,
!P__P!PN$W%._Mh
X (!1I2# ! (2$&h&/)*;2(%I%(G/D(%A6/&/E)*6/%(b%$) 0G#(I$) 2#(%$2hWh=W;
D(00(&/GG&40/) I/5(&9(h=G2$>(4%/&1G$)5!P_N^!X_ $X%.
ONLh
[ (!
ñÎ=
!
ñÏì
!
H¤©
!
‡
h
p…QÊÌü⃄8æ
9(h
ŒrÏ£¤
! WMPM!O[$N%.PXPNh
N (!R(&d//U/?9!/U(&$)5 73! .$%V(%B=! (2$&h-KU(%I()2$&
$G42(2#%/Ib/2G02%/V() b$b//)09(h12%/V(! P_NX! P[ $X%.
PWL^h
_ (!
>tó
!
“7Ž
!
ß7í
!
‡
h
I\]¶·[QA|ڛp…
/PMOW/
{
OX
ï{
PX
•
WMPP
÷
N
²
!!!!!! ! ! ! ! ! !!!! ! ! ! !
S/&hOX! :004(!PX
=4*402! WMPP
QGªôh¾D
9(h
r­Ð¥ã¥£¤
!P__^! PM$P%._Lh
PM(!?)0b(%*12%)V(! P_N_! WM$PW%.PXW[h
PP(!
45
!
“Ð
h
°±²ÆÊÌüâƒÜ8æirÇÇéýþ[
ÿ‘
9(h
ÇÌýþ
!WMPM!OO$P%.WWh
PW(!
š²
!
—­²
h
uvOp…Q
Z
֖?üâg•–ƒ„
9(h
ñriÖËxÐ
!P___!X$O%.P^Lh
PO(!
ñ<
!
Ñ¡
!
қ
!
‡
h
<=¤
#
ý¤GªÉÊÑÒ23
p…QuvÇéýþGE›Ý܃„
9(h
r­rÇ£¤
!
WMMX!OP$PP%._M[h
8SAGS0AW0CAKD/O10KE0CL /C0./1.BHA1K/L/0CKD0KUEA.0U
UAGAOGBU/GH0/UH0KA/KA/CHDE0CX0CL /OBIDAM0U/UF AS/1I/D0BC
BMDG/H0D0BC/12E0CAKA.AH0U0CA
1,>3/)*
P
!
! d.=>?c$f)$)
W
$Ph)>.3?<3: H,4,./*> #*.?,@A<=(/.?0!0<3.-6>03,4,8,?0*03,! Q03.3 WLMMP^! 6>03.&
Wh)>.3?<3: %30K,/40!A<=(/.?0!0<3.-6>03,4,8,?0*03,! Q03.3 WLMOLL! 6>03.%
6OKDG/UD(! :) /%5(%2/(KU&/%(2#(U$2#/*()(00/60G#(IGG(%(b%/D$0G4&$%50($0(! 5%4*0G%(())*! (6G$GA(D$&4$2/) $)5
2%($2I()2U&$) /U2I`$2/)! I$)AV)50/6$)I$&I/5(&0$*$)020G#(IGG(%(b%/G$%5$GE(%((02$b&0#(5 E2# /U(%$2/) 04GG(00D(&A
) %(G()2A($%0h=GG/%5)*2/2#(G#$%$G2(%02G/62%$52/)$&#)(0(I(5G)(! 2f0$]4(02/) 2/G#//0(2#($UU%/U%$2($)I$&I/5(&
6/%5%4*0G%(())*$)5 (6G$GA(D$&4$2/)! $)5 2/G/Ib)(2#(G(%(b%$&0G#(I$/6$)I$&I/5(&0E2# G&)G$&50($0(%(0($%G# G&/0(;
&Ah@#(02$b&2A$)5 %(&$b&2A/6$)I$&I/5(&0$)5 2#((6G$GA/65%4*0) G&)G$&0#/4&5 b(G/)05(%(5 ) /%5(%2/U%/D5((6(G2D(
5%4*0G%(())*(D$&4$2/) %(0($%G# 2//&0h
A^F WBGHK(!0G#(IGG(%(b%/D$0G4&$%50($0(& (6G$GA(D$&4$2/)& $)I$&I/5(&0
HB0.!+_%#)RU[U..#+!!!$+
$
˜™$Q
!
ª««
%
/WMOW/
{
OX
ï{
PX
•
WMPP
÷
N
²
!!!!!! ! ! ! ! ! !!!! ! ! ! !
S/&hOX! :004(!PX
=4*402! WMPP