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期 刊 ：中国中药杂志 2008年 33卷 06期 页码：691.

关键词：通幽清；便秘型肠易激综合征；病例对照研究；替加色罗；结肠运输试验；

Keywords:Tongyouqing, irritable bowel syndrome,

摘 要 ：目的:探讨通幽清治疗便秘型肠易激综合征(C-IBS)的疗效。方法:按罗马标准Ⅱ选择58例C-IBS患者随机分2组,对照组28例给予替加色罗(6 mg,bid),治疗组30例给于通幽清颗粒冲剂,疗程为4周,观察比较用药前后IBS症状评估(Bristol评分、腹胀、腹痛、排便困难、排便不尽、精神方面),通过结肠运输试验了解结肠动力改善情况,比较二者的有效率及治疗后仍选择原来药物的比例。结果:在治疗前后2组患者IBS症状评分,二组间比较有明显差异(P<0.05);治疗后结肠动力改善方面,治疗组明显优于对照组(P<0.05);有效率及治疗后仍选择原来药物的比例治疗组亦明显优于对照组(P<0.05)。结论:通幽清能快速明显缓解胃肠道症状、改善大便性状、减轻腹痛腹胀、增加大便次数、改善精神状态、增加结肠动力,是治疗C-IBS的有效方法,值得临床推广。

Abstract:Objective: To explore the effect of Tongyouqing treating the C-IBS.Method: According to rome standard Ⅱ,fifty-eithy C-IBS patients were randomly divided into two groups.Control group(28 cases) were given tijiaseluo(6 mg,qd).Treatment group(30 cases) were given Tongyouqing.After treatment for 4 weeks,observing and comparing the two groups IBS symptom between treatment before and later(Bristol score,abdominal distention,abdominal angina,constipation,partial defecation,belch,mind).To understand the condition of the colonic dynamic by colonic transit trial.Comparing the effective rate of the two group and the proportion of patients still choosing the medicine which they were given.Result: The symptom score of the two groups patients,there were significant differences between the two groups before treatment and after treatment(P<0.05).After treatment,treatment group is prefer to control group in the improvement of the colonic dynamic(P<0.05).The effective rate and the proportion of patients still choosing the medicine which they were given of treatment group is also more higher than control group.Conclusion: Tongyouqing can relieve the gastrointestinal symptom,improve the fecal character,lessen abdominal distention and abdominal angina,increase the defecating times,improve the colonic dynamic,improve the mind state quilkly and manifestly.Tongyouqing is an effective method to treat C-IBS.It deserves clinical spreading,its mechnism needs further study.

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