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期 刊 ：中国中药杂志 2006年 31卷 08期 页码：621.

关键词：代谢组学；中医药复杂理论系统；辨证论治；脏象理论；中药方剂；肠道菌群微生态学；

Keywords:metabonomics, complexed theory system of TCM, treatment based on syndrome differentiation, Zang-xiang theory, intestinal microflora ecology,

摘 要 ：新兴学科代谢组学的出现,给中医药复杂理论体系的研究、中医药现代化提供了强有力的研究手段。中医病证引起代谢物组的共性分析和生物标记物的发现,可促进“证”本质的研究、中医辨证的科学化和定量化,深层次理解中医脏象理论,预测疾病的发生,整体性评价中药复方综合疗效、安全性和作用机制,反应肠道内生态环境状况。代谢组学和中医药学的结合,将探索出中医药复杂理论体系研究的新方法与新途径。

Abstract:Metabonomics,a new and rapid-developing technology,will be powerful means to the research of complexed theory system and modernization of traditional Chinese medicine(TCM).Discovery of biomarkers and analysis of common properties from the metabolome of a specific TCM syndrome will facilitate the modernized study of TCM system,promote the quantitative and scientific elucidation of TCM syndrome differentiation,provide an in-depth understanding of the TCM theory of Zang-xiang,help predict the disease on-set,and achieve a comprehensive evaluation of systemic clinical efficacy,safety and mechanism of action of the TCM combination formulas along with a better understanding of intestinal microflora ecology.The new approach with combined metabonomics and TCM methodologies will provide a new pathway and methodology for the study of complicated theory system of TCM and its modernization.

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