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期 刊 ：中国中药杂志 2007年 32卷 05期 页码：391.

关键词：雄黄；胃内滞留漂浮片；均匀设计；相关分析；优选；

Keywords:Realgar, floating tablets for gastric retention, uniform design, correlation analysis, optimization,

摘 要 ：目的：利用均匀设计法及相关分析优选雄黄胃内滞留漂浮片的处方配比。方法：以不同处方配比的羟丙甲基纤维素（HPMC）为骨架材料,采用均匀设计法及相关分析筛选制剂配方并进行体外累积溶出度的测定。结果：体外溶出度符合实验预期要求；释药机制是通过溶蚀和扩散同时完成的。结论：雄黄胃内漂浮滞留片基本达到设计要求,满足缓释、安全的要求。

Abstract:Objective：To optimize the different components proportions of the Realgar floating tablets for gastric retention by uniform design and correlation analysis.Method：With the different dosage of hydroxypropyl methyl cellulose (HPMC) as the tablets‘ frame matrix, uniform design and correlation analysis were used to optimize the best component proportions of formula, and to measure the dissolution of the tablets in vitro.Result：Dissolution of the tablets in vitro was conformed to the expectation of experiment. The drug-release mechanism was by diffusion and corrosion at the same time. Conclusion：The Realgar floating tablets for gastric retention achieved the goal of design, which demand sustained release and safety.

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