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期 刊 ：中国中药杂志 2008年 33卷 12期 页码：1466.

关键词：舒经克痛软胶囊；缩宫素；子宫活动；痛经；

Keywords:Shujing Ketong soft capsules, oxytocin, uterine activity, dysmenorrhea,

摘 要 ：目的：观察舒经克痛软胶囊对离体大鼠子及在体大鼠子宫活动的影响。方法：离体大鼠子宫置于改良Genell氏液内，在其中加入终浓度分别为0.96，1.92，3.84，7.68，15.36 mg·L^-1的舒经克痛软胶囊；采用十二指肠给药9.6，19.2，38.4 μg·g^-1的受试药物和2 g·kg^-1的月月舒，分别观察药物对大鼠离体子宫和在体子宫收缩频率、幅度、活动力的影响。结果：舒经克痛软胶囊可明显抑制大鼠正常离体子宫的收缩频率、幅度、活动力；能降低由于缩宫素引起的大鼠离体子宫收缩增强作用；能降低缩宫素引起的在体大鼠子宫的收缩频率、幅度、活动力，对子宫收缩具有增强作用。结论：舒经克痛软胶囊可用于治疗平滑肌痉挛所致的痛经。

Abstract:Objective: To observe effects of Shujing Ketong soft capsules (SJKTSC) on activities of the uterine of the rat in vitro and in vivo. Method: The isolated rat uterine were mounted in the improved Genell solution with a final content of 0.96, 1.92, 3.84 μg·g^-1 of SJKTSC at 37 ℃; and 9.6, 19.2, 38.4 mg·kg^-1 of SJKTSC and 2 g·kg^-1 of Tongjingbao granules were given to the rat through the duodenum respectively. Their effects on frequency, amplitude and activity of contraction of rat uterus in vitro and in vivo were investigated. Result: SJKTSC could significantly inhibit the frequency, amplitude and activity of contraction of the normal rat uterus in vitro and decrease the oxytocin-induced increase of contraction of the rat uterus in vitro; lowered the frequency, amplitude and activity of the oxytocin-induced contraction of the rat uterus in vivo and inhibit the oxytocin-induced the strengthening of contraction of the rat uterus in vivo. Conclusion: Shujing Ketong soft capsules maybe used for treatment of dysmenorrhea induced by spasm of uterine smooth muscle.

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