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期 刊 ：中国中药杂志 2005年 30卷 21期 页码：1651.

关键词：水飞蓟素；固体脂质纳米粒；生物利用度；

Keywords:silymarin, solid lipid nanoparticles, bioavailability,

摘 要 ：目的:考察不同粒径的固体脂质纳米粒对大鼠口服吸收水飞蓟素的影响。方法:以山榆酸甘油酯为载体材料,分别制备了150,500,1 000 nm 3种粒径的水飞蓟素固体脂质纳米粒,给大鼠灌胃后,采用RP-HPLC测定不同时间点血药浓度,数据经3p97软件进行处理。结果:口服150 nm水飞蓟素固体脂质纳米粒后的AUC分别是500,1 000 nm的2.08,2.54倍(P<0.05),这表明150 nm固体脂质纳米粒的生物利用度明显高于其他2种制剂。结论:固体脂质纳米粒粒径对水飞蓟素的口服吸收有着显著影响。

Abstract:Objective: To invetigate effect of particle size on oral absorption of silymarin-loaded solid lipid nanoparuicles.Method: Solid lipid nanoparticles(SLN) of various sizes(150 nm,500 nm and 1 000 nm) using Compritol 888 ATO as the material and silymarin(SM) as a model drug were prepared.Silybinin concentration in plasma of rats were determined by RP-HPLC with UV detector.The main pharmacokinetic parameters were calculated by 3p97. Result: Results showed that the AUC of 150 nm SLN was 2.08 fold that of 500 nm SLN and 2.54 fold of 1 000 nm SLN treated orally to rats(P<0.05).The oral bioavailability of 150nm SLN was remarkably higher than the other two size SLN.Conclusion: This has important implications in designing of SM-SLN as a new oral drug delivery system.

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