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期 刊 ：中国中药杂志 1998年 23卷 04期 页码：230.

关键词：生脉散；5-羟甲基-2-糠醛；复方化学；

Keywords:Shengmaisan, 5-hydroxymethyl-2-furaldehyde, prescription chemistry,

摘 要 ：为探讨生脉散全方独特疗效作用的物质基础，对其煎煮后的化学成分进行了研究。从生脉散合煎剂中分离得到一个复方产生的新成分，经ＵＶ，ＩＲ，ＭＳ及ＮＭＲ谱鉴定为5-羟甲基-2-糠醛。研究表明，复方独特疗效有其独特的物质基础，与单味药及其简单加和在化学成分上有本质区别。从而阐明了中药配伍应用的合理性和科学性，并为制定复方制剂的质量检测提供了依据。

Abstract:To clarify the material base of the distinct curative effect of Shengmaisan (SMS) compound prescription,a study was made on the dynamics of chemical constituents in the decoction prepared according to the compound prescription.From the decoction a new compound was isolated and identified by UV,IR,MS and NMR as 5-hydroxymethy 2-furaldehyde (5 HMF).The study suggests that the distinct curative effect of SMS compound prescription hinges on a material base which is different chemically from that in the other three single drugs used separately,thus presenting scientific criteria for rational compatibility and quality check in making preparations on compound prescriptions.

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